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Molecular Pharmacology

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Research ArticleArticle

Phosphodiesterase 4 Inhibitors Augment the Ability of Formoterol to Enhance Glucocorticoid-Dependent Gene Transcription in Human Airway Epithelial Cells: A Novel Mechanism for the Clinical Efficacy of Roflumilast in Severe Chronic Obstructive Pulmonary Disease

Thunicia Moodley, Sylvia M. Wilson, Taruna Joshi, Christopher F. Rider, Pawan Sharma, Dong Yan, Robert Newton and Mark A. Giembycz
Molecular Pharmacology April 2013, 83 (4) 894-906; DOI: https://doi.org/10.1124/mol.112.083493
Thunicia Moodley
Departments of Physiology and Pharmacology (T.M., S.M.W., T.J., P.S., D.Y., M.A.G.) and Cell Biology and Anatomy (C.F.R., R.N.), Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
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Sylvia M. Wilson
Departments of Physiology and Pharmacology (T.M., S.M.W., T.J., P.S., D.Y., M.A.G.) and Cell Biology and Anatomy (C.F.R., R.N.), Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
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Taruna Joshi
Departments of Physiology and Pharmacology (T.M., S.M.W., T.J., P.S., D.Y., M.A.G.) and Cell Biology and Anatomy (C.F.R., R.N.), Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
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Christopher F. Rider
Departments of Physiology and Pharmacology (T.M., S.M.W., T.J., P.S., D.Y., M.A.G.) and Cell Biology and Anatomy (C.F.R., R.N.), Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
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Pawan Sharma
Departments of Physiology and Pharmacology (T.M., S.M.W., T.J., P.S., D.Y., M.A.G.) and Cell Biology and Anatomy (C.F.R., R.N.), Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
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Dong Yan
Departments of Physiology and Pharmacology (T.M., S.M.W., T.J., P.S., D.Y., M.A.G.) and Cell Biology and Anatomy (C.F.R., R.N.), Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
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Robert Newton
Departments of Physiology and Pharmacology (T.M., S.M.W., T.J., P.S., D.Y., M.A.G.) and Cell Biology and Anatomy (C.F.R., R.N.), Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
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Mark A. Giembycz
Departments of Physiology and Pharmacology (T.M., S.M.W., T.J., P.S., D.Y., M.A.G.) and Cell Biology and Anatomy (C.F.R., R.N.), Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
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Article Information

vol. 83 no. 4 894-906
DOI 
https://doi.org/10.1124/mol.112.083493
PubMed 
23389862

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received November 6, 2012
  • Accepted February 5, 2013
  • Published online March 19, 2013.

Article Versions

  • Earlier version (February 6, 2013 - 06:38).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Thunicia Moodley,
  2. Sylvia M. Wilson,
  3. Taruna Joshi,
  4. Christopher F. Rider,
  5. Pawan Sharma,
  6. Dong Yan,
  7. Robert Newton, and
  8. Mark A. Giembycz
  1. Departments of Physiology and Pharmacology (T.M., S.M.W., T.J., P.S., D.Y., M.A.G.) and Cell Biology and Anatomy (C.F.R., R.N.), Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
  1. Address correspondence to:
    Dr. Mark A. Giembycz, Department of Physiology & Pharmacology, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1. E-mail: giembycz{at}ucalgary.ca
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Molecular Pharmacology: 83 (4)
Molecular Pharmacology
Vol. 83, Issue 4
1 Apr 2013
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Phosphodiesterase 4 Inhibitors Augment the Ability of Formoterol to Enhance Glucocorticoid-Dependent Gene Transcription in Human Airway Epithelial Cells: A Novel Mechanism for the Clinical Efficacy of Roflumilast in Severe Chronic Obstructive Pulmonary D…
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Research ArticleArticle

Roflumilast, GRE-Dependent Transcription, and Severe COPD

Thunicia Moodley, Sylvia M. Wilson, Taruna Joshi, Christopher F. Rider, Pawan Sharma, Dong Yan, Robert Newton and Mark A. Giembycz
Molecular Pharmacology April 1, 2013, 83 (4) 894-906; DOI: https://doi.org/10.1124/mol.112.083493

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Research ArticleArticle

Roflumilast, GRE-Dependent Transcription, and Severe COPD

Thunicia Moodley, Sylvia M. Wilson, Taruna Joshi, Christopher F. Rider, Pawan Sharma, Dong Yan, Robert Newton and Mark A. Giembycz
Molecular Pharmacology April 1, 2013, 83 (4) 894-906; DOI: https://doi.org/10.1124/mol.112.083493
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