Table of Contents

Articles

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  Murine Oatp1a/1b Uptake Transporters Control Rosuvastatin Systemic Exposure Without Affecting Its Apparent Liver Exposure

  Dilek Iusuf, Anita van Esch, Michael Hobbs, Maxine Taylor, Kathryn E. Kenworthy, Evita van de Steeg, Els Wagenaar and Alfred H. Schinkel

  Molecular Pharmacology May 2013, 83 (5) 919-929; DOI: https://doi.org/10.1124/mol.112.081927
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  Vesnarinone Suppresses TNFα mRNA Expression by Inhibiting Valosin-Containing Protein

  Kentaro Hotta, Akihiro Nashimoto, Eiji Yasumura, Masafumi Suzuki, Motoki Azuma, Yosuke Iizumi, Daisuke Shima, Ryusuke Nabeshima, Masaki Hiramoto, Akira Okada, Kumiko Sakata-Sogawa, Makio Tokunaga, Takumi Ito, Hideki Ando, Satoshi Sakamoto, Yasuaki Kabe, Shinichi Aizawa, Takeshi Imai, Yuki Yamaguchi, Hajime Watanabe and Hiroshi Handa

  Molecular Pharmacology May 2013, 83 (5) 930-938; DOI: https://doi.org/10.1124/mol.112.081935
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  α_1A-Adrenergic Receptors Regulate Cardiac Hypertrophy In Vivo Through Interleukin-6 Secretion

  Robert S. Papay, Ting Shi, Michael T. Piascik, Sathyamangla V. Naga Prasad and Dianne M. Perez

  Molecular Pharmacology May 2013, 83 (5) 939-948; DOI: https://doi.org/10.1124/mol.112.084483
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  Pharmacology and Structure of Isolated Conformations of the Adenosine A_2A Receptor Define Ligand Efficacy

  Kirstie A. Bennett, Benjamin Tehan, Guillaume Lebon, Christopher G. Tate, Malcolm Weir, Fiona H. Marshall and Christopher J. Langmead

  Molecular Pharmacology May 2013, 83 (5) 949-958; DOI: https://doi.org/10.1124/mol.112.084509
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  Molecular Mechanism Regulating 24-Hour Rhythm of Dopamine D3 Receptor Expression in Mouse Ventral Striatum

  Eriko Ikeda, Naoya Matsunaga, Keisuke Kakimoto, Kengo Hamamura, Akane Hayashi, Satoru Koyanagi and Shigehiro Ohdo

  Molecular Pharmacology May 2013, 83 (5) 959-967; DOI: https://doi.org/10.1124/mol.112.083535
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  Upregulation of Drug Transporter Expression by Osteopontin in Prostate Cancer Cells

  I-Shan Hsieh, Wei-Hsun Huang, Houng-Chi Liou, Woei-Jer Chuang, Rong-Sen Yang and Wen-Mei Fu

  Molecular Pharmacology May 2013, 83 (5) 968-977; DOI: https://doi.org/10.1124/mol.112.082339
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  NADPH Oxidase NOX5-S and Nuclear Factor κB1 Mediate Acid-Induced Microsomal Prostaglandin E Synthase-1 Expression in Barrett’s Esophageal Adenocarcinoma Cells

  Xiaoxu Zhou, Dan Li, Murray B. Resnick, Jack Wands and Weibiao Cao

  Molecular Pharmacology May 2013, 83 (5) 978-990; DOI: https://doi.org/10.1124/mol.112.083287
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  Probing the Metabotropic Glutamate Receptor 5 (mGlu₅) Positive Allosteric Modulator (PAM) Binding Pocket: Discovery of Point Mutations That Engender a “Molecular Switch” in PAM Pharmacology

  Karen J. Gregory, Elizabeth D. Nguyen, Sean D. Reiff, Emma F. Squire, Shaun R. Stauffer, Craig W. Lindsley, Jens Meiler and P. Jeffrey Conn

  Molecular Pharmacology May 2013, 83 (5) 991-1006; DOI: https://doi.org/10.1124/mol.112.083949
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  Sensory Nerve Terminal Mitochondrial Dysfunction Activates Airway Sensory Nerves via Transient Receptor Potential (TRP) Channels

  Lika Nesuashvili, Stephen H. Hadley, Parmvir K. Bahia and Thomas E. Taylor-Clark

  Molecular Pharmacology May 2013, 83 (5) 1007-1019; DOI: https://doi.org/10.1124/mol.112.084319
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  Discovery, Molecular and Pharmacological Characterization of GSA-10, a Novel Small-Molecule Positive Modulator of Smoothened

  Tatiana Gorojankina, Lucile Hoch, Hélène Faure, Hermine Roudaut, Elisabeth Traiffort, Angèle Schoenfelder, Nicolas Girard, André Mann, Fabrizio Manetti, Antonio Solinas, Elena Petricci, Maurizio Taddei and Martial Ruat

  Molecular Pharmacology May 2013, 83 (5) 1020-1029; DOI: https://doi.org/10.1124/mol.112.084590
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  Cerebrovascular Dilation via Selective Targeting of the Cholane Steroid-Recognition Site in the BK Channel β1-Subunit by a Novel Nonsteroidal Agent

  Anna N. Bukiya, Jacob E. McMillan, Alexander L. Fedinec, Shivaputra A. Patil, Duane D. Miller, Charles W. Leffler, Abby L. Parrill and Alex M. Dopico

  Molecular Pharmacology May 2013, 83 (5) 1030-1044; DOI: https://doi.org/10.1124/mol.112.083519
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  Contribution of the M1 Transmembrane Helix and Pre-M1 Region to Positive Allosteric Modulation and Gating of N-Methyl-d-Aspartate Receptors

  Kevin K. Ogden and Stephen F. Traynelis

  Molecular Pharmacology May 2013, 83 (5) 1045-1056; DOI: https://doi.org/10.1124/mol.113.085209
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  Activation of Both Protein Kinase A (PKA) Type I and PKA Type II Isozymes Is Required for Retinoid-Induced Maturation of Acute Promyelocytic Leukemia Cells

  Eric Nguyen, Gro Gausdal, Jacqueline Varennes, Frédéric Pendino, Michel Lanotte, Stein Ove Døskeland and Evelyne Ségal-Bendirdjian

  Molecular Pharmacology May 2013, 83 (5) 1057-1065; DOI: https://doi.org/10.1124/mol.112.081034
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  Cooperative Activation of Gene Expression by Agonists and Antagonists Mediated by Estrogen Receptor Heteroligand Dimer Complexes

  Shuang Liu, Sang Jun Han and Carolyn L. Smith

  Molecular Pharmacology May 2013, 83 (5) 1066-1077; DOI: https://doi.org/10.1124/mol.112.084228
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  Identification of Functionally Relevant Lysine Residues That Modulate Human Farnesoid X Receptor Activation

  An-Qiang Sun, Yuhuan Luo, Donald S. Backos, Shuhua Xu, Natarajan Balasubramaniyan, Philip Reigan and Frederick J. Suchy

  Molecular Pharmacology May 2013, 83 (5) 1078-1086; DOI: https://doi.org/10.1124/mol.113.084772
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  Cross-Desensitization and Cointernalization of H1 and H2 Histamine Receptors Reveal New Insights into Histamine Signal Integration

  Natalia Alonso, Natalia Fernandez, Cintia Notcovich, Federico Monczor, May Simaan, Alberto Baldi, J. Silvio Gutkind, Carlos Davio and Carina Shayo

  Molecular Pharmacology May 2013, 83 (5) 1087-1098; DOI: https://doi.org/10.1124/mol.112.083394
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  A Newly Synthesized Sinapic Acid Derivative Inhibits Endothelial Activation In Vitro and In Vivo

  Xiaoyun Zeng, Jinhong Zheng, Chenglai Fu, Hang Su, Xiaoli Sun, Xuesi Zhang, Yingjian Hou and Yi Zhu

  Molecular Pharmacology May 2013, 83 (5) 1099-1108; DOI: https://doi.org/10.1124/mol.112.084368
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  Neuroglobin, a Novel Intracellular Hexa-Coordinated Globin, Functions as a Tumor Suppressor in Hepatocellular Carcinoma via Raf/MAPK/Erk

  Jun Zhang, Shu Jue Lan, Qian Rong Liu, Ju Mei Liu and Xiao Qian Chen

  Molecular Pharmacology May 2013, 83 (5) 1109-1119; DOI: https://doi.org/10.1124/mol.112.083634
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  Benzoquinone Reveals a Cysteine-Dependent Desensitization Mechanism of TRPA1

  Yessenia Ibarra and Nathaniel T. Blair

  Molecular Pharmacology May 2013, 83 (5) 1120-1132; DOI: https://doi.org/10.1124/mol.112.084194
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  Aryl Hydrocarbon Receptor Modulates NADPH Oxidase Activity via Direct Transcriptional Regulation of p40^phox Expression

  Taira Wada, Hiroshi Sunaga, Reiko Ohkawara and Shigeki Shimba

  Molecular Pharmacology May 2013, 83 (5) 1133-1140; DOI: https://doi.org/10.1124/mol.112.083303
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  Cucurbitacin I Inhibits Rac1 Activation in Breast Cancer Cells by a Reactive Oxygen Species-Mediated Mechanism and Independently of Janus Tyrosine Kinase 2 and P-Rex1

  Cynthia Lopez-Haber and Marcelo G. Kazanietz

  Molecular Pharmacology May 2013, 83 (5) 1141-1154; DOI: https://doi.org/10.1124/mol.112.084293