Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Molecular Pharmacology
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Molecular Pharmacology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit molpharm on Facebook
  • Follow molpharm on Twitter
  • Follow molpharm on LinkedIn
Rapid CommunicationMinireview

Cellular Mechanisms of Nociceptin/Orphanin FQ (N/OFQ) Peptide (NOP) Receptor Regulation and Heterologous Regulation by N/OFQ

Courtney L. Donica, Hibah O. Awwad, Deepak R. Thakker and Kelly M. Standifer
Molecular Pharmacology May 2013, 83 (5) 907-918; DOI: https://doi.org/10.1124/mol.112.084632
Courtney L. Donica
Oklahoma Center for Neuroscience (C.L.D., H.O.A., K.M.S.) and Department of Cell Biology (K.M.S.), College of Medicine and Department of Pharmaceutical Sciences, College of Pharmacy (H.O.A., K.M.S.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; and University of Houston College of Pharmacy, Houston, Texas (D.R.T.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hibah O. Awwad
Oklahoma Center for Neuroscience (C.L.D., H.O.A., K.M.S.) and Department of Cell Biology (K.M.S.), College of Medicine and Department of Pharmaceutical Sciences, College of Pharmacy (H.O.A., K.M.S.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; and University of Houston College of Pharmacy, Houston, Texas (D.R.T.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Deepak R. Thakker
Oklahoma Center for Neuroscience (C.L.D., H.O.A., K.M.S.) and Department of Cell Biology (K.M.S.), College of Medicine and Department of Pharmaceutical Sciences, College of Pharmacy (H.O.A., K.M.S.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; and University of Houston College of Pharmacy, Houston, Texas (D.R.T.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kelly M. Standifer
Oklahoma Center for Neuroscience (C.L.D., H.O.A., K.M.S.) and Department of Cell Biology (K.M.S.), College of Medicine and Department of Pharmaceutical Sciences, College of Pharmacy (H.O.A., K.M.S.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; and University of Houston College of Pharmacy, Houston, Texas (D.R.T.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is the fourth and most recently discovered member of the opioid receptor superfamily that also includes μ, δ, and κ opioid receptor subtypes (MOR, DOR, and KOR, respectively). The widespread anatomic distribution of the NOP receptor enables the modulation of several physiologic processes by its endogenous agonist, N/OFQ. Accordingly, the NOP receptor has gained a lot of attention as a potential target for the development of ligands with therapeutic use in several pathophysiological states. NOP receptor activation frequently results in effects opposing classic opioid receptor action; therefore, regulation of the NOP receptor and conditions affecting its modulatory tone are important to understand. Mounting evidence reveals a heterologous interaction of the NOP receptor with other G protein–coupled receptors, including MOR, DOR, and KOR, which may subsequently influence their function. Our focus in this review is to summarize and discuss the findings that delineate the cellular mechanisms of NOP receptor signaling and regulation and the regulation of other receptors by N/OFQ and the NOP receptor.

Footnotes

    • Received December 20, 2012.
    • Accepted February 8, 2013.
  • This work was supported by the Oklahoma Center for the Advancement of Science and Technology’s OHRS Award [Project HR08-152]; the National Institutes of Health National Institute on Drug Abuse [Grant R01-DA017380]; and the Department of the Army [DMRDP W81XWH-11-2-0077].

  • The information and interpretations included in this article do not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred.

  • ↵1Current affiliation: Medtronic Neuromodulation, Minneapolis, Minnesota.

  • dx.doi.org/10.1124/mol.112.084632.

  • U.S. Government work not protected by U.S. copyright.
View Full Text

MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Molecular Pharmacology: 83 (5)
Molecular Pharmacology
Vol. 83, Issue 5
1 May 2013
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Molecular Pharmacology article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Cellular Mechanisms of Nociceptin/Orphanin FQ (N/OFQ) Peptide (NOP) Receptor Regulation and Heterologous Regulation by N/OFQ
(Your Name) has forwarded a page to you from Molecular Pharmacology
(Your Name) thought you would be interested in this article in Molecular Pharmacology.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Rapid CommunicationMinireview

Cellular Mechanisms of NOP Receptor Regulation

Courtney L. Donica, Hibah O. Awwad, Deepak R. Thakker and Kelly M. Standifer
Molecular Pharmacology May 1, 2013, 83 (5) 907-918; DOI: https://doi.org/10.1124/mol.112.084632

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Rapid CommunicationMinireview

Cellular Mechanisms of NOP Receptor Regulation

Courtney L. Donica, Hibah O. Awwad, Deepak R. Thakker and Kelly M. Standifer
Molecular Pharmacology May 1, 2013, 83 (5) 907-918; DOI: https://doi.org/10.1124/mol.112.084632
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • NOP Receptor Signaling
    • Homologous NOP Receptor Desensitization
    • Heterologous Regulation of the NOP Receptor
    • Heterologous Regulation by N/OFQ
    • Heterodimerization
    • NOP Receptor Function, Pain, and Inflammatory Response: The Role of NOP Receptor Regulation
    • Conclusion
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • mGlu Receptors: Novel Therapeutic Targets for Schizophrenia
  • G Protein-Coupled Receptor Phosphorylation and Rab Proteins
  • Review of TOP2 Covalent Complex Repair Mechanisms
Show more Minireview

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About Molecular Pharmacology
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Journal of Pharmacology and Experimental Therapeutics
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0111 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics