Research ArticleArticle
Vesnarinone Suppresses TNFα mRNA Expression by Inhibiting Valosin-Containing Protein
Kentaro Hotta, Akihiro Nashimoto, Eiji Yasumura, Masafumi Suzuki, Motoki Azuma, Yosuke Iizumi, Daisuke Shima, Ryusuke Nabeshima, Masaki Hiramoto, Akira Okada, Kumiko Sakata-Sogawa, Makio Tokunaga, Takumi Ito, Hideki Ando, Satoshi Sakamoto, Yasuaki Kabe, Shinichi Aizawa, Takeshi Imai, Yuki Yamaguchi, Hajime Watanabe and Hiroshi Handa
Molecular Pharmacology May 2013, 83 (5) 930-938; DOI: https://doi.org/10.1124/mol.112.081935
Kentaro Hotta
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Akihiro Nashimoto
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Eiji Yasumura
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Masafumi Suzuki
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Motoki Azuma
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Yosuke Iizumi
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Daisuke Shima
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Ryusuke Nabeshima
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Masaki Hiramoto
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Akira Okada
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Kumiko Sakata-Sogawa
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Makio Tokunaga
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Takumi Ito
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Hideki Ando
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Satoshi Sakamoto
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Yasuaki Kabe
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Shinichi Aizawa
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Takeshi Imai
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Yuki Yamaguchi
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Hajime Watanabe
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Hiroshi Handa
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
Article Information
vol. 83 no. 5 930-938
PubMed
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History
- Received August 21, 2012
- Accepted February 7, 2013
- Published online April 15, 2013.
Article Versions
- Earlier version (February 7, 2013 - 11:02).
- You are viewing the most recent version of this article.
Copyright & Usage
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics
Author Information
- Kentaro Hotta,
- Akihiro Nashimoto,
- Eiji Yasumura,
- Masafumi Suzuki,
- Motoki Azuma,
- Yosuke Iizumi,
- Daisuke Shima,
- Ryusuke Nabeshima,
- Masaki Hiramoto,
- Akira Okada,
- Kumiko Sakata-Sogawa,
- Makio Tokunaga,
- Takumi Ito,
- Hideki Ando,
- Satoshi Sakamoto,
- Yasuaki Kabe,
- Shinichi Aizawa,
- Takeshi Imai,
- Yuki Yamaguchi,
- Hajime Watanabe, and
- Hiroshi Handa
- Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan (K.H., A.N., E.Y., M.S., M.A., D.S., R.N., A.O., T.It., H.A., K.S.-S., M.T. S.S., Y.K., Y.Y., H.H.); Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan (Y.I.); Department of Metabolic Disorder, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan (M.H.); Department of Anatomy, Nihon University School of Medicine, Tokyo, Japan (S.A.); Department of Aging Intervention, National Center for Geriatrics and Gerontology, Aichi, Japan (T.Im.); and Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan (H.W.)
- Address correspondence to:
Dr. Hiroshi Handa, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuda-cho, Midori-ku, Yokohama, 226-8503, Japan. E-mail: handa.h.aa{at}m.titech.ac.jp
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Research ArticleArticle
Vesnarinone Inhibits Valosin-Containing Protein
Kentaro Hotta, Akihiro Nashimoto, Eiji Yasumura, Masafumi Suzuki, Motoki Azuma, Yosuke Iizumi, Daisuke Shima, Ryusuke Nabeshima, Masaki Hiramoto, Akira Okada, Kumiko Sakata-Sogawa, Makio Tokunaga, Takumi Ito, Hideki Ando, Satoshi Sakamoto, Yasuaki Kabe, Shinichi Aizawa, Takeshi Imai, Yuki Yamaguchi, Hajime Watanabe and Hiroshi Handa
Molecular Pharmacology May 1, 2013, 83 (5) 930-938; DOI: https://doi.org/10.1124/mol.112.081935
Research ArticleArticle
Vesnarinone Inhibits Valosin-Containing Protein
Kentaro Hotta, Akihiro Nashimoto, Eiji Yasumura, Masafumi Suzuki, Motoki Azuma, Yosuke Iizumi, Daisuke Shima, Ryusuke Nabeshima, Masaki Hiramoto, Akira Okada, Kumiko Sakata-Sogawa, Makio Tokunaga, Takumi Ito, Hideki Ando, Satoshi Sakamoto, Yasuaki Kabe, Shinichi Aizawa, Takeshi Imai, Yuki Yamaguchi, Hajime Watanabe and Hiroshi Handa
Molecular Pharmacology May 1, 2013, 83 (5) 930-938; DOI: https://doi.org/10.1124/mol.112.081935
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