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Overexpression of Mcl-1 Confers Multidrug Resistance, Whereas Topoisomerase IIβ Downregulation Introduces Mitoxantrone-Specific Drug Resistance in Acute Myeloid Leukemia

David L. Hermanson, Sonia G. Das, Yunfang Li and Chengguo Xing
Molecular Pharmacology August 2013, 84 (2) 236-243; DOI: https://doi.org/10.1124/mol.113.086140

Article Information

vol. 84 no. 2 236-243
DOI 
https://doi.org/10.1124/mol.113.086140
PubMed 
23696245
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received March 12, 2013
  • Accepted May 21, 2013
  • Published online July 16, 2013.

Article Versions

Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. David L. Hermanson,
  2. Sonia G. Das,
  3. Yunfang Li, and
  4. Chengguo Xing
  1. Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (D.L.H., S.G.D., Y.L., C.X.); and Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts (S.G.D.)
  1. Address correspondence to:
    Dr. Chengguo Xing, Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, 308 Harvard St SE, Minneapolis, MN 55455. E-mail: xingx009{at}umn.edu
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Drug-Resistant Mechanisms in AML

David L. Hermanson, Sonia G. Das, Yunfang Li and Chengguo Xing
Molecular Pharmacology August 1, 2013, 84 (2) 236-243; DOI: https://doi.org/10.1124/mol.113.086140
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