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Research ArticleArticle

Human Immunodeficiency Virus Protease Inhibitors Interact with ATP Binding Cassette Transporter 4/Multidrug Resistance Protein 4: A Basis for Unanticipated Enhanced Cytotoxicity

Yu Fukuda, Kazumasa Takenaka, Alex Sparreboom, Satish B. Cheepala, Chung-Pu Wu, Sean Ekins, Suresh V. Ambudkar and John D. Schuetz
Molecular Pharmacology September 2013, 84 (3) 361-371; DOI: https://doi.org/10.1124/mol.113.086967
Yu Fukuda
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (Y.F., K.T., A.S., S.B.C., J.D.S.); Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.-P.W., S.V.A.); and Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.)
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Kazumasa Takenaka
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (Y.F., K.T., A.S., S.B.C., J.D.S.); Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.-P.W., S.V.A.); and Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.)
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Alex Sparreboom
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (Y.F., K.T., A.S., S.B.C., J.D.S.); Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.-P.W., S.V.A.); and Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.)
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Satish B. Cheepala
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (Y.F., K.T., A.S., S.B.C., J.D.S.); Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.-P.W., S.V.A.); and Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.)
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Chung-Pu Wu
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (Y.F., K.T., A.S., S.B.C., J.D.S.); Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.-P.W., S.V.A.); and Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.)
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Sean Ekins
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (Y.F., K.T., A.S., S.B.C., J.D.S.); Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.-P.W., S.V.A.); and Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.)
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Suresh V. Ambudkar
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (Y.F., K.T., A.S., S.B.C., J.D.S.); Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.-P.W., S.V.A.); and Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.)
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John D. Schuetz
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (Y.F., K.T., A.S., S.B.C., J.D.S.); Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.-P.W., S.V.A.); and Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.)
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Article Information

vol. 84 no. 3 361-371
DOI 
https://doi.org/10.1124/mol.113.086967
PubMed 
23775562

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received April 22, 2013
  • Accepted June 17, 2013
  • Published online August 9, 2013.

Article Versions

  • Earlier version (June 17, 2013 - 12:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
U.S. Government work not protected by U.S. copyright

Author Information

  1. Yu Fukuda,
  2. Kazumasa Takenaka,
  3. Alex Sparreboom,
  4. Satish B. Cheepala,
  5. Chung-Pu Wu,
  6. Sean Ekins,
  7. Suresh V. Ambudkar, and
  8. John D. Schuetz
  1. Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (Y.F., K.T., A.S., S.B.C., J.D.S.); Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.-P.W., S.V.A.); and Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.)
  1. Address correspondence to:
    Dr. John D. Schuetz, Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 313, Memphis, TN 38105-3678. E-mail: John.Schuetz{at}stjude.org
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Molecular Pharmacology: 84 (3)
Molecular Pharmacology
Vol. 84, Issue 3
1 Sep 2013
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Research ArticleArticle

HIV Protease Inhibitors and MRP4

Yu Fukuda, Kazumasa Takenaka, Alex Sparreboom, Satish B. Cheepala, Chung-Pu Wu, Sean Ekins, Suresh V. Ambudkar and John D. Schuetz
Molecular Pharmacology September 1, 2013, 84 (3) 361-371; DOI: https://doi.org/10.1124/mol.113.086967

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Research ArticleArticle

HIV Protease Inhibitors and MRP4

Yu Fukuda, Kazumasa Takenaka, Alex Sparreboom, Satish B. Cheepala, Chung-Pu Wu, Sean Ekins, Suresh V. Ambudkar and John D. Schuetz
Molecular Pharmacology September 1, 2013, 84 (3) 361-371; DOI: https://doi.org/10.1124/mol.113.086967
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