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Research ArticleArticle

Connective Tissue Growth Factor/CCN2 Attenuates β-Adrenergic Receptor Responsiveness and Cardiotoxicity by Induction of G Protein–Coupled Receptor Kinase-5 in Cardiomyocytes

Jørgen Gravning, M. Shakil Ahmed, Eirik Qvigstad, Kurt Krobert, Thor Edvardsen, Ingvild Tronstad Moe, Else Marie V. Hagelin, Julia Sagave, Guro Valen, Finn Olav Levy, Jan-Bjørn Osnes, Tor Skomedal and Håvard Attramadal
Molecular Pharmacology September 2013, 84 (3) 372-383; DOI: https://doi.org/10.1124/mol.113.087312
Jørgen Gravning
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
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M. Shakil Ahmed
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
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Eirik Qvigstad
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
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Kurt Krobert
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
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Thor Edvardsen
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
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Ingvild Tronstad Moe
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
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Else Marie V. Hagelin
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
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Julia Sagave
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
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Guro Valen
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
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Finn Olav Levy
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
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Jan-Bjørn Osnes
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
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Tor Skomedal
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
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Håvard Attramadal
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
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Article Information

vol. 84 no. 3 372-383
DOI 
https://doi.org/10.1124/mol.113.087312
PubMed 
23778361

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received May 11, 2013
  • Accepted June 18, 2013
  • Published online August 9, 2013.

Article Versions

  • Earlier version (June 18, 2013 - 08:38).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jørgen Gravning,
  2. M. Shakil Ahmed,
  3. Eirik Qvigstad,
  4. Kurt Krobert,
  5. Thor Edvardsen,
  6. Ingvild Tronstad Moe,
  7. Else Marie V. Hagelin,
  8. Julia Sagave,
  9. Guro Valen,
  10. Finn Olav Levy,
  11. Jan-Bjørn Osnes,
  12. Tor Skomedal, and
  13. Håvard Attramadal
  1. Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
  1. Address correspondence to:
    Dr. Håvard Attramadal, Institute for Surgical Research, Oslo University Hospital, Rikshospitalet, P.O. Box 4950, Nydalen, NO-0424 Oslo, Norway. E-mail: havard.attramadal{at}medisin.uio.no
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Molecular Pharmacology: 84 (3)
Molecular Pharmacology
Vol. 84, Issue 3
1 Sep 2013
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Research ArticleArticle

CTGF-Induced Desensitization of β-ARs

Jørgen Gravning, M. Shakil Ahmed, Eirik Qvigstad, Kurt Krobert, Thor Edvardsen, Ingvild Tronstad Moe, Else Marie V. Hagelin, Julia Sagave, Guro Valen, Finn Olav Levy, Jan-Bjørn Osnes, Tor Skomedal and Håvard Attramadal
Molecular Pharmacology September 1, 2013, 84 (3) 372-383; DOI: https://doi.org/10.1124/mol.113.087312

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Research ArticleArticle

CTGF-Induced Desensitization of β-ARs

Jørgen Gravning, M. Shakil Ahmed, Eirik Qvigstad, Kurt Krobert, Thor Edvardsen, Ingvild Tronstad Moe, Else Marie V. Hagelin, Julia Sagave, Guro Valen, Finn Olav Levy, Jan-Bjørn Osnes, Tor Skomedal and Håvard Attramadal
Molecular Pharmacology September 1, 2013, 84 (3) 372-383; DOI: https://doi.org/10.1124/mol.113.087312
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