Research ArticleArticle
Connective Tissue Growth Factor/CCN2 Attenuates β-Adrenergic Receptor Responsiveness and Cardiotoxicity by Induction of G Protein–Coupled Receptor Kinase-5 in Cardiomyocytes
Jørgen Gravning, M. Shakil Ahmed, Eirik Qvigstad, Kurt Krobert, Thor Edvardsen, Ingvild Tronstad Moe, Else Marie V. Hagelin, Julia Sagave, Guro Valen, Finn Olav Levy, Jan-Bjørn Osnes, Tor Skomedal and Håvard Attramadal
Molecular Pharmacology September 2013, 84 (3) 372-383; DOI: https://doi.org/10.1124/mol.113.087312
Jørgen Gravning
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
M. Shakil Ahmed
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
Eirik Qvigstad
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
Kurt Krobert
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
Thor Edvardsen
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
Ingvild Tronstad Moe
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
Else Marie V. Hagelin
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
Julia Sagave
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
Guro Valen
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
Finn Olav Levy
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
Jan-Bjørn Osnes
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
Tor Skomedal
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
Håvard Attramadal
Institute for Surgical Research (J.G., M.S.A., I.T.M., E.M.V.H., H.A.) and Departments of Cardiology (H.A., T.E.) and Pharmacology (E.Q., K.K., F.O.L., J.-B.O., T.S.), Oslo University Hospital and University of Oslo, Oslo, Norway; and Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.-B.O., T.S., H.A.), K. G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.-B.O., T.S.), and Department of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway
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CTGF-Induced Desensitization of β-ARs
Jørgen Gravning, M. Shakil Ahmed, Eirik Qvigstad, Kurt Krobert, Thor Edvardsen, Ingvild Tronstad Moe, Else Marie V. Hagelin, Julia Sagave, Guro Valen, Finn Olav Levy, Jan-Bjørn Osnes, Tor Skomedal and Håvard Attramadal
Molecular Pharmacology September 1, 2013, 84 (3) 372-383; DOI: https://doi.org/10.1124/mol.113.087312
Research ArticleArticle
CTGF-Induced Desensitization of β-ARs
Jørgen Gravning, M. Shakil Ahmed, Eirik Qvigstad, Kurt Krobert, Thor Edvardsen, Ingvild Tronstad Moe, Else Marie V. Hagelin, Julia Sagave, Guro Valen, Finn Olav Levy, Jan-Bjørn Osnes, Tor Skomedal and Håvard Attramadal
Molecular Pharmacology September 1, 2013, 84 (3) 372-383; DOI: https://doi.org/10.1124/mol.113.087312
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