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Molecular Pharmacology

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Research ArticleArticle

Brain-Derived Neurotrophic Factor–Mediated Downregulation of Brainstem K+–Cl– Cotransporter and Cell-Type–Specific GABA Impairment for Activation of Descending Pain Facilitation

Zhi Zhang, Xinxing Wang, Wei Wang, Yun-Gang Lu and Zhizhong Z. Pan
Molecular Pharmacology October 2013, 84 (4) 511-520; DOI: https://doi.org/10.1124/mol.113.086496
Zhi Zhang
Department of Anesthesiology and Pain Medicine, University of Texas, MD Anderson Cancer Center, Houston, Texas (Z.Z., W.W., Z.Z.P.); Department of Neurobiology, University of Science and Technology of China, Hefei, People’s Republic of China (Z.Z., X.W.); and Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas (Y.-G.L.)
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Xinxing Wang
Department of Anesthesiology and Pain Medicine, University of Texas, MD Anderson Cancer Center, Houston, Texas (Z.Z., W.W., Z.Z.P.); Department of Neurobiology, University of Science and Technology of China, Hefei, People’s Republic of China (Z.Z., X.W.); and Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas (Y.-G.L.)
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Wei Wang
Department of Anesthesiology and Pain Medicine, University of Texas, MD Anderson Cancer Center, Houston, Texas (Z.Z., W.W., Z.Z.P.); Department of Neurobiology, University of Science and Technology of China, Hefei, People’s Republic of China (Z.Z., X.W.); and Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas (Y.-G.L.)
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Yun-Gang Lu
Department of Anesthesiology and Pain Medicine, University of Texas, MD Anderson Cancer Center, Houston, Texas (Z.Z., W.W., Z.Z.P.); Department of Neurobiology, University of Science and Technology of China, Hefei, People’s Republic of China (Z.Z., X.W.); and Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas (Y.-G.L.)
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Zhizhong Z. Pan
Department of Anesthesiology and Pain Medicine, University of Texas, MD Anderson Cancer Center, Houston, Texas (Z.Z., W.W., Z.Z.P.); Department of Neurobiology, University of Science and Technology of China, Hefei, People’s Republic of China (Z.Z., X.W.); and Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas (Y.-G.L.)
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Article Information

vol. 84 no. 4 511-520
DOI 
https://doi.org/10.1124/mol.113.086496
PubMed 
23847084

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received March 1, 2013
  • Accepted July 11, 2013
  • Published online September 10, 2013.

Article Versions

  • Earlier version (July 11, 2013 - 11:03).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Zhi Zhang,
  2. Xinxing Wang,
  3. Wei Wang,
  4. Yun-Gang Lu, and
  5. Zhizhong Z. Pan
  1. Department of Anesthesiology and Pain Medicine, University of Texas, MD Anderson Cancer Center, Houston, Texas (Z.Z., W.W., Z.Z.P.); Department of Neurobiology, University of Science and Technology of China, Hefei, People’s Republic of China (Z.Z., X.W.); and Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas (Y.-G.L.)
  1. Address correspondence to:
    Zhizhong Z. Pan, Department of Anesthesiology and Pain Medicine, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 110, Houston, TX 77030. E-mail: zzpan{at}mdanderson.org
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Molecular Pharmacology: 84 (4)
Molecular Pharmacology
Vol. 84, Issue 4
1 Oct 2013
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Research ArticleArticle

Brainstem BDNF and KCC2 in Descending Pain Facilitation

Zhi Zhang, Xinxing Wang, Wei Wang, Yun-Gang Lu and Zhizhong Z. Pan
Molecular Pharmacology October 1, 2013, 84 (4) 511-520; DOI: https://doi.org/10.1124/mol.113.086496

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Research ArticleArticle

Brainstem BDNF and KCC2 in Descending Pain Facilitation

Zhi Zhang, Xinxing Wang, Wei Wang, Yun-Gang Lu and Zhizhong Z. Pan
Molecular Pharmacology October 1, 2013, 84 (4) 511-520; DOI: https://doi.org/10.1124/mol.113.086496
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