Research ArticleArticle
Functional Validation of Virtual Screening for Novel Agents with General Anesthetic Action at Ligand-Gated Ion Channels
Stephanie A. Heusser, Rebecca J. Howard, Cecilia M. Borghese, Madeline A. Cullins, Torben Broemstrup, Ui S. Lee, Erik Lindahl, Jens Carlsson and R. Adron Harris
Molecular Pharmacology November 2013, 84 (5) 670-678; DOI: https://doi.org/10.1124/mol.113.087692
Stephanie A. Heusser
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
Rebecca J. Howard
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
Cecilia M. Borghese
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
Madeline A. Cullins
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
Torben Broemstrup
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
Ui S. Lee
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
Erik Lindahl
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
Jens Carlsson
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
R. Adron Harris
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland (S.A.H.); Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas (R.J.H., C.M.B., M.A.C., U.S.L., R.A.H.); Science for Life Laboratory, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden (T.B., E.L.); and Department of Biochemistry and Biophysics, Center for Biomembrane Research, Science for Life Laboratory, Stockholm University, Stockholm, Sweden (J.C.)
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Research ArticleArticle
Validation of Virtual Screening for Anesthetics in LGICs
Stephanie A. Heusser, Rebecca J. Howard, Cecilia M. Borghese, Madeline A. Cullins, Torben Broemstrup, Ui S. Lee, Erik Lindahl, Jens Carlsson and R. Adron Harris
Molecular Pharmacology November 1, 2013, 84 (5) 670-678; DOI: https://doi.org/10.1124/mol.113.087692
Research ArticleArticle
Validation of Virtual Screening for Anesthetics in LGICs
Stephanie A. Heusser, Rebecca J. Howard, Cecilia M. Borghese, Madeline A. Cullins, Torben Broemstrup, Ui S. Lee, Erik Lindahl, Jens Carlsson and R. Adron Harris
Molecular Pharmacology November 1, 2013, 84 (5) 670-678; DOI: https://doi.org/10.1124/mol.113.087692
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