Table of Contents

Articles

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  Structure-Based Ligand Discovery Targeting Orthosteric and Allosteric Pockets of Dopamine Receptors

  J. Robert Lane, Pavel Chubukov, Wei Liu, Meritxell Canals, Vadim Cherezov, Ruben Abagyan, Raymond C. Stevens and Vsevolod Katritch

  Molecular Pharmacology December 2013, 84 (6) 794-807; DOI: https://doi.org/10.1124/mol.113.088054
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  Hepatocyte Nuclear Factors 4α and 1α Regulate Kidney Developmental Expression of Drug-Metabolizing Enzymes and Drug Transporters

  Gleb Martovetsky, James B. Tee and Sanjay K. Nigam

  Molecular Pharmacology December 2013, 84 (6) 808-823; DOI: https://doi.org/10.1124/mol.113.088229
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  Salicylic Acid Induces Mitochondrial Injury by Inhibiting Ferrochelatase Heme Biosynthesis Activity

  Vipul Gupta, Shujie Liu, Hideki Ando, Ryohei Ishii, Shumpei Tateno, Yuki Kaneko, Masato Yugami, Satoshi Sakamoto, Yuki Yamaguchi, Osamu Nureki and Hiroshi Handa

  Molecular Pharmacology December 2013, 84 (6) 824-833; DOI: https://doi.org/10.1124/mol.113.087940
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  Enzymatic Activity of CaMKII Is Not Required for Its Interaction with the Glutamate Receptor Subunit GluN2B

  Kelsey Barcomb, Steven J. Coultrap and K. Ulrich Bayer

  Molecular Pharmacology December 2013, 84 (6) 834-843; DOI: https://doi.org/10.1124/mol.113.089045
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  A Novel Noncanonical Signaling Pathway for the µ-Opioid Receptor

  Lei Zhang, Horace H. Loh and Ping-Yee Law

  Molecular Pharmacology December 2013, 84 (6) 844-853; DOI: https://doi.org/10.1124/mol.113.088278
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  A Single Glycine in Extracellular Loop 1 Is the Critical Determinant for Pharmacological Specificity of Dopamine D2 and D3 Receptors

  Mayako Michino, Prashant Donthamsetti, Thijs Beuming, Ashwini Banala, Lihua Duan, Thomas Roux, Yang Han, Eric Trinquet, Amy Hauck Newman, Jonathan A. Javitch and Lei Shi

  Molecular Pharmacology December 2013, 84 (6) 854-864; DOI: https://doi.org/10.1124/mol.113.087833
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  Mycoplasma hyorhinis–Encoded Purine Nucleoside Phosphorylase: Kinetic Properties and Its Effect on the Cytostatic Potential of Purine-Based Anticancer Drugs

  Johan Vande Voorde, Sandra Liekens and Jan Balzarini

  Molecular Pharmacology December 2013, 84 (6) 865-875; DOI: https://doi.org/10.1124/mol.113.088625
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  Orexin-A Activates Hypothalamic AMP-Activated Protein Kinase Signaling through a Ca²⁺-Dependent Mechanism Involving Voltage-Gated L-Type Calcium Channel

  Wen-Ning Wu, Peng-Fei Wu, Jun Zhou, Xin-Lei Guan, Zui Zhang, Yuan-Jian Yang, Li-Hong Long, Na Xie, Jian-Guo Chen and Fang Wang

  Molecular Pharmacology December 2013, 84 (6) 876-887; DOI: https://doi.org/10.1124/mol.113.086744
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  The Iron-Binding Protein Lactoferrin Protects Vulnerable Dopamine Neurons from Degeneration by Preserving Mitochondrial Calcium Homeostasis

  Erwann Rousseau, Patrick P. Michel and Etienne C. Hirsch

  Molecular Pharmacology December 2013, 84 (6) 888-898; DOI: https://doi.org/10.1124/mol.113.087965
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  Mechanism of Action of Novel Lung Edema Therapeutic AP301 by Activation of the Epithelial Sodium Channel

  Waheed Shabbir, Parastoo Scherbaum-Hazemi, Susan Tzotzos, Bernhard Fischer, Hendrik Fischer, Helmut Pietschmann, Rudolf Lucas and Rosa Lemmens-Gruber

  Molecular Pharmacology December 2013, 84 (6) 899-910; DOI: https://doi.org/10.1124/mol.113.089409
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  Cellular Uptake of the Antitumor Agent Dp44mT Occurs via a Carrier/Receptor-Mediated Mechanism

  Angelica M. Merlot, Namfon Pantarat, Sharleen V. Menezes, Sumit Sahni, Des R. Richardson and Danuta S. Kalinowski

  Molecular Pharmacology December 2013, 84 (6) 911-924; DOI: https://doi.org/10.1124/mol.113.088393
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  Epoxyeicosatrienoic Acids Prevent Cisplatin-Induced Renal Apoptosis through a p38 Mitogen-Activated Protein Kinase–Regulated Mitochondrial Pathway

  Yingmei Liu, Xiaodan Lu, Sinh Nguyen, Jean L. Olson, Heather K. Webb and Deanna L. Kroetz

  Molecular Pharmacology December 2013, 84 (6) 925-934; DOI: https://doi.org/10.1124/mol.113.088302
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  Indistinguishable Synaptic Pharmacodynamics of the N-Methyl-d-Aspartate Receptor Channel Blockers Memantine and Ketamine

  Christine M. Emnett, Lawrence N. Eisenman, Amanda M. Taylor, Yukitoshi Izumi, Charles F. Zorumski and Steven Mennerick

  Molecular Pharmacology December 2013, 84 (6) 935-947; DOI: https://doi.org/10.1124/mol.113.089334