Research ArticleArticle
Identification of Novel Functionally Selective κ-Opioid Receptor Scaffolds
Kate L. White, Alex P. Scopton, Marie-Laure Rives, Ruslan V. Bikbulatov, Prabhakar R. Polepally, Peter J. Brown, Terrance Kenakin, Jonathan A. Javitch, Jordan K. Zjawiony and Bryan L. Roth
Molecular Pharmacology January 2014, 85 (1) 83-90; DOI: https://doi.org/10.1124/mol.113.089649
Kate L. White
Department of Pharmacology (K.L.W., T.K., B.L.R.) and National Institute of Mental Health Psychoactive Drug Screening Program (B.L.R.), University of North Carolina, Chapel Hill, North Carolina; Departments of Psychiatry (M.-L.R, J.A.J.) and Pharmacology (J.A.J.), Columbia University, College of Physicians and Surgeons, New York, New York; New York Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York (M.-L.R., J.A.J.); Department of Pharmacognosy, University of Mississippi, University, Mississippi (R.V.B., P.R.P., J.K.Z.); and Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada (A.P.S., P.J.B.)
Alex P. Scopton
Department of Pharmacology (K.L.W., T.K., B.L.R.) and National Institute of Mental Health Psychoactive Drug Screening Program (B.L.R.), University of North Carolina, Chapel Hill, North Carolina; Departments of Psychiatry (M.-L.R, J.A.J.) and Pharmacology (J.A.J.), Columbia University, College of Physicians and Surgeons, New York, New York; New York Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York (M.-L.R., J.A.J.); Department of Pharmacognosy, University of Mississippi, University, Mississippi (R.V.B., P.R.P., J.K.Z.); and Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada (A.P.S., P.J.B.)
Marie-Laure Rives
Department of Pharmacology (K.L.W., T.K., B.L.R.) and National Institute of Mental Health Psychoactive Drug Screening Program (B.L.R.), University of North Carolina, Chapel Hill, North Carolina; Departments of Psychiatry (M.-L.R, J.A.J.) and Pharmacology (J.A.J.), Columbia University, College of Physicians and Surgeons, New York, New York; New York Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York (M.-L.R., J.A.J.); Department of Pharmacognosy, University of Mississippi, University, Mississippi (R.V.B., P.R.P., J.K.Z.); and Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada (A.P.S., P.J.B.)
Ruslan V. Bikbulatov
Department of Pharmacology (K.L.W., T.K., B.L.R.) and National Institute of Mental Health Psychoactive Drug Screening Program (B.L.R.), University of North Carolina, Chapel Hill, North Carolina; Departments of Psychiatry (M.-L.R, J.A.J.) and Pharmacology (J.A.J.), Columbia University, College of Physicians and Surgeons, New York, New York; New York Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York (M.-L.R., J.A.J.); Department of Pharmacognosy, University of Mississippi, University, Mississippi (R.V.B., P.R.P., J.K.Z.); and Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada (A.P.S., P.J.B.)
Prabhakar R. Polepally
Department of Pharmacology (K.L.W., T.K., B.L.R.) and National Institute of Mental Health Psychoactive Drug Screening Program (B.L.R.), University of North Carolina, Chapel Hill, North Carolina; Departments of Psychiatry (M.-L.R, J.A.J.) and Pharmacology (J.A.J.), Columbia University, College of Physicians and Surgeons, New York, New York; New York Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York (M.-L.R., J.A.J.); Department of Pharmacognosy, University of Mississippi, University, Mississippi (R.V.B., P.R.P., J.K.Z.); and Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada (A.P.S., P.J.B.)
Peter J. Brown
Department of Pharmacology (K.L.W., T.K., B.L.R.) and National Institute of Mental Health Psychoactive Drug Screening Program (B.L.R.), University of North Carolina, Chapel Hill, North Carolina; Departments of Psychiatry (M.-L.R, J.A.J.) and Pharmacology (J.A.J.), Columbia University, College of Physicians and Surgeons, New York, New York; New York Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York (M.-L.R., J.A.J.); Department of Pharmacognosy, University of Mississippi, University, Mississippi (R.V.B., P.R.P., J.K.Z.); and Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada (A.P.S., P.J.B.)
Terrance Kenakin
Department of Pharmacology (K.L.W., T.K., B.L.R.) and National Institute of Mental Health Psychoactive Drug Screening Program (B.L.R.), University of North Carolina, Chapel Hill, North Carolina; Departments of Psychiatry (M.-L.R, J.A.J.) and Pharmacology (J.A.J.), Columbia University, College of Physicians and Surgeons, New York, New York; New York Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York (M.-L.R., J.A.J.); Department of Pharmacognosy, University of Mississippi, University, Mississippi (R.V.B., P.R.P., J.K.Z.); and Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada (A.P.S., P.J.B.)
Jonathan A. Javitch
Department of Pharmacology (K.L.W., T.K., B.L.R.) and National Institute of Mental Health Psychoactive Drug Screening Program (B.L.R.), University of North Carolina, Chapel Hill, North Carolina; Departments of Psychiatry (M.-L.R, J.A.J.) and Pharmacology (J.A.J.), Columbia University, College of Physicians and Surgeons, New York, New York; New York Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York (M.-L.R., J.A.J.); Department of Pharmacognosy, University of Mississippi, University, Mississippi (R.V.B., P.R.P., J.K.Z.); and Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada (A.P.S., P.J.B.)
Jordan K. Zjawiony
Department of Pharmacology (K.L.W., T.K., B.L.R.) and National Institute of Mental Health Psychoactive Drug Screening Program (B.L.R.), University of North Carolina, Chapel Hill, North Carolina; Departments of Psychiatry (M.-L.R, J.A.J.) and Pharmacology (J.A.J.), Columbia University, College of Physicians and Surgeons, New York, New York; New York Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York (M.-L.R., J.A.J.); Department of Pharmacognosy, University of Mississippi, University, Mississippi (R.V.B., P.R.P., J.K.Z.); and Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada (A.P.S., P.J.B.)
Bryan L. Roth
Department of Pharmacology (K.L.W., T.K., B.L.R.) and National Institute of Mental Health Psychoactive Drug Screening Program (B.L.R.), University of North Carolina, Chapel Hill, North Carolina; Departments of Psychiatry (M.-L.R, J.A.J.) and Pharmacology (J.A.J.), Columbia University, College of Physicians and Surgeons, New York, New York; New York Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York (M.-L.R., J.A.J.); Department of Pharmacognosy, University of Mississippi, University, Mississippi (R.V.B., P.R.P., J.K.Z.); and Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada (A.P.S., P.J.B.)
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Research ArticleArticle
κ-Opioid Receptor Biased Ligands
Kate L. White, Alex P. Scopton, Marie-Laure Rives, Ruslan V. Bikbulatov, Prabhakar R. Polepally, Peter J. Brown, Terrance Kenakin, Jonathan A. Javitch, Jordan K. Zjawiony and Bryan L. Roth
Molecular Pharmacology January 1, 2014, 85 (1) 83-90; DOI: https://doi.org/10.1124/mol.113.089649
Research ArticleArticle
κ-Opioid Receptor Biased Ligands
Kate L. White, Alex P. Scopton, Marie-Laure Rives, Ruslan V. Bikbulatov, Prabhakar R. Polepally, Peter J. Brown, Terrance Kenakin, Jonathan A. Javitch, Jordan K. Zjawiony and Bryan L. Roth
Molecular Pharmacology January 1, 2014, 85 (1) 83-90; DOI: https://doi.org/10.1124/mol.113.089649
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