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Molecular Pharmacology

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Research ArticleArticle

Structural and Functional Analysis of G Protein–Coupled Receptor Kinase Inhibition by Paroxetine and a Rationally Designed Analog

Kristoff T. Homan, Emily Wu, Michael W. Wilson, Puja Singh, Scott D. Larsen and John J. G. Tesmer
Molecular Pharmacology February 2014, 85 (2) 237-248; DOI: https://doi.org/10.1124/mol.113.089631
Kristoff T. Homan
Life Sciences Institute and the Departments of Pharmacology and Biological Sciences (K.T.H., E.W., P.S., J.J.G.T.), and Vahlteich Medicinal Chemistry Core and the Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan (M.W.W., S.D.L.)
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Emily Wu
Life Sciences Institute and the Departments of Pharmacology and Biological Sciences (K.T.H., E.W., P.S., J.J.G.T.), and Vahlteich Medicinal Chemistry Core and the Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan (M.W.W., S.D.L.)
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Michael W. Wilson
Life Sciences Institute and the Departments of Pharmacology and Biological Sciences (K.T.H., E.W., P.S., J.J.G.T.), and Vahlteich Medicinal Chemistry Core and the Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan (M.W.W., S.D.L.)
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Puja Singh
Life Sciences Institute and the Departments of Pharmacology and Biological Sciences (K.T.H., E.W., P.S., J.J.G.T.), and Vahlteich Medicinal Chemistry Core and the Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan (M.W.W., S.D.L.)
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Scott D. Larsen
Life Sciences Institute and the Departments of Pharmacology and Biological Sciences (K.T.H., E.W., P.S., J.J.G.T.), and Vahlteich Medicinal Chemistry Core and the Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan (M.W.W., S.D.L.)
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John J. G. Tesmer
Life Sciences Institute and the Departments of Pharmacology and Biological Sciences (K.T.H., E.W., P.S., J.J.G.T.), and Vahlteich Medicinal Chemistry Core and the Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan (M.W.W., S.D.L.)
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Article Information

vol. 85 no. 2 237-248
DOI 
https://doi.org/10.1124/mol.113.089631
PubMed 
24220010

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received September 17, 2013
  • Accepted November 11, 2013
  • Published online December 20, 2013.

Article Versions

  • Earlier version (November 12, 2013 - 08:32).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kristoff T. Homan,
  2. Emily Wu,
  3. Michael W. Wilson,
  4. Puja Singh,
  5. Scott D. Larsen, and
  6. John J. G. Tesmer
  1. Life Sciences Institute and the Departments of Pharmacology and Biological Sciences (K.T.H., E.W., P.S., J.J.G.T.), and Vahlteich Medicinal Chemistry Core and the Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan (M.W.W., S.D.L.)
  1. Address correspondence to:
    Dr. John J. G. Tesmer, Life Sciences Institute, The University of Michigan, 210 Washtenaw Ave. Rm 3425, Ann Arbor, MI 48109. E-mail: tesmerjj{at}umich.edu
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Molecular Pharmacology: 85 (2)
Molecular Pharmacology
Vol. 85, Issue 2
1 Feb 2014
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Research ArticleArticle

Inhibition of GRKs by Paroxetine Analogs

Kristoff T. Homan, Emily Wu, Michael W. Wilson, Puja Singh, Scott D. Larsen and John J. G. Tesmer
Molecular Pharmacology February 1, 2014, 85 (2) 237-248; DOI: https://doi.org/10.1124/mol.113.089631

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Research ArticleArticle

Inhibition of GRKs by Paroxetine Analogs

Kristoff T. Homan, Emily Wu, Michael W. Wilson, Puja Singh, Scott D. Larsen and John J. G. Tesmer
Molecular Pharmacology February 1, 2014, 85 (2) 237-248; DOI: https://doi.org/10.1124/mol.113.089631
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