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Research ArticleArticle

Metformin Represses Drug-Induced Expression of CYP2B6 by Modulating the Constitutive Androstane Receptor Signaling

Hui Yang, Brandy Garzel, Scott Heyward, Timothy Moeller, Paul Shapiro and Hongbing Wang
Molecular Pharmacology February 2014, 85 (2) 249-260; DOI: https://doi.org/10.1124/mol.113.089763
Hui Yang
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland (H.Y., B.G., P.S., H.W.); and Bioreclamation In Vitro Technologies (S.H., T.M.), Baltimore, Maryland
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Brandy Garzel
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland (H.Y., B.G., P.S., H.W.); and Bioreclamation In Vitro Technologies (S.H., T.M.), Baltimore, Maryland
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Scott Heyward
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland (H.Y., B.G., P.S., H.W.); and Bioreclamation In Vitro Technologies (S.H., T.M.), Baltimore, Maryland
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Timothy Moeller
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland (H.Y., B.G., P.S., H.W.); and Bioreclamation In Vitro Technologies (S.H., T.M.), Baltimore, Maryland
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Paul Shapiro
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland (H.Y., B.G., P.S., H.W.); and Bioreclamation In Vitro Technologies (S.H., T.M.), Baltimore, Maryland
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Hongbing Wang
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland (H.Y., B.G., P.S., H.W.); and Bioreclamation In Vitro Technologies (S.H., T.M.), Baltimore, Maryland
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Article Information

vol. 85 no. 2 249-260
DOI 
https://doi.org/10.1124/mol.113.089763
PubMed 
24252946

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received September 18, 2013
  • Accepted November 18, 2013
  • Published online December 20, 2013.

Article Versions

  • Earlier version (November 19, 2013 - 10:37).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hui Yang,
  2. Brandy Garzel,
  3. Scott Heyward,
  4. Timothy Moeller,
  5. Paul Shapiro, and
  6. Hongbing Wang
  1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland (H.Y., B.G., P.S., H.W.); and Bioreclamation In Vitro Technologies (S.H., T.M.), Baltimore, Maryland
  1. Address correspondence to:
    Hongbing Wang, Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn St., Baltimore, MD 21201. E-mail: hwang{at}rx.umaryland.edu
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Molecular Pharmacology: 85 (2)
Molecular Pharmacology
Vol. 85, Issue 2
1 Feb 2014
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Research ArticleArticle

Metformin Suppresses CYP2B6 Induction by CAR Phosphorylation

Hui Yang, Brandy Garzel, Scott Heyward, Timothy Moeller, Paul Shapiro and Hongbing Wang
Molecular Pharmacology February 1, 2014, 85 (2) 249-260; DOI: https://doi.org/10.1124/mol.113.089763

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Research ArticleArticle

Metformin Suppresses CYP2B6 Induction by CAR Phosphorylation

Hui Yang, Brandy Garzel, Scott Heyward, Timothy Moeller, Paul Shapiro and Hongbing Wang
Molecular Pharmacology February 1, 2014, 85 (2) 249-260; DOI: https://doi.org/10.1124/mol.113.089763
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