Table of Contents

Articles

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  Recovery of Current through Mutated TASK3 Potassium Channels Underlying Birk Barel Syndrome

  Emma L. Veale, Mustafa Hassan, Yvonne Walsh, Ehab Al-Moubarak and Alistair Mathie

  Molecular Pharmacology March 2014, 85 (3) 397-407; DOI: https://doi.org/10.1124/mol.113.090530
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  Phosphodiesterase 5 Inhibitors Enhance Chemotherapy Killing in Gastrointestinal/Genitourinary Cancer Cells

  Laurence Booth, Jane L. Roberts, Nichola Cruickshanks, Adam Conley, David E. Durrant, Anindita Das, Paul B. Fisher, Rakesh C. Kukreja, Steven Grant, Andrew Poklepovic and Paul Dent

  Molecular Pharmacology March 2014, 85 (3) 408-419; DOI: https://doi.org/10.1124/mol.113.090043
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  Pore-Exposed Tyrosine Residues of P-Glycoprotein Are Important Hydrogen-Bonding Partners for Drugs

  Yaprak Dönmez Cakil, Narakorn Khunweeraphong, Zahida Parveen, Diethart Schmid, Matthias Artaker, Gerhard F. Ecker, Harald H. Sitte, Oliver Pusch, Thomas Stockner and Peter Chiba

  Molecular Pharmacology March 2014, 85 (3) 420-428; DOI: https://doi.org/10.1124/mol.113.088526
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  Novel Small Molecule Inhibitors of TLR7 and TLR9: Mechanism of Action and Efficacy In Vivo

  Marc Lamphier, Wanjun Zheng, Eicke Latz, Mark Spyvee, Hans Hansen, Jeffrey Rose, Melinda Genest, Hua Yang, Christina Shaffer, Yan Zhao, Yongchun Shen, Carrie Liu, Diana Liu, Thorsten R. Mempel, Christopher Rowbottom, Jesse Chow, Natalie C. Twine, Melvin Yu, Fabian Gusovsky and Sally T. Ishizaka

  Molecular Pharmacology March 2014, 85 (3) 429-440; DOI: https://doi.org/10.1124/mol.113.089821
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  cdc-Like/Dual-Specificity Tyrosine Phosphorylation–Regulated Kinases Inhibitor Leucettine L41 Induces mTOR-Dependent Autophagy: Implication for Alzheimer’s Disease

  Xavier Fant, Emilie Durieu, Gaëtan Chicanne, Bernard Payrastre, Diego Sbrissa, Assia Shisheva, Emmanuelle Limanton, François Carreaux, Jean-Pierre Bazureau and Laurent Meijer

  Molecular Pharmacology March 2014, 85 (3) 441-450; DOI: https://doi.org/10.1124/mol.113.090837
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  Triapine and a More Potent Dimethyl Derivative Induce Endoplasmic Reticulum Stress in Cancer Cells

  Robert Trondl, Lea S. Flocke, Christian R. Kowol, Petra Heffeter, Ute Jungwirth, Georg E. Mair, Ralf Steinborn, Éva A. Enyedy, Michael A. Jakupec, Walter Berger and Bernhard K. Keppler

  Molecular Pharmacology March 2014, 85 (3) 451-459; DOI: https://doi.org/10.1124/mol.113.090605
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  5′-AMP-Activated Protein Kinase Attenuates Adriamycin-Induced Oxidative Podocyte Injury through Thioredoxin-Mediated Suppression of the Apoptosis Signal-Regulating Kinase 1–P38 Signaling Pathway

  Kun Gao, Yuan Chi, Wei Sun, Masayuki Takeda and Jian Yao

  Molecular Pharmacology March 2014, 85 (3) 460-471; DOI: https://doi.org/10.1124/mol.113.089458
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  Regulation of β₂-Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies

  Dean P. Staus, Laura M. Wingler, Ryan T. Strachan, Soren G. F. Rasmussen, Els Pardon, Seungkirl Ahn, Jan Steyaert, Brian K. Kobilka and Robert J. Lefkowitz

  Molecular Pharmacology March 2014, 85 (3) 472-481; DOI: https://doi.org/10.1124/mol.113.089516
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  Differential Roles of Ubiquitination in the Degradation Mechanism of Cell Surface–Resident Bile Salt Export Pump and Multidrug Resistance–Associated Protein 2

  Kensuke Aida, Hisamitsu Hayashi, Kaori Inamura, Tadahaya Mizuno and Yuichi Sugiyama

  Molecular Pharmacology March 2014, 85 (3) 482-491; DOI: https://doi.org/10.1124/mol.113.091090
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  Quantification of Ligand Bias for Clinically Relevant β₂-Adrenergic Receptor Ligands: Implications for Drug Taxonomy

  Emma T. van der Westhuizen, Billy Breton, Arthur Christopoulos and Michel Bouvier

  Molecular Pharmacology March 2014, 85 (3) 492-509; DOI: https://doi.org/10.1124/mol.113.088880
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  Mutation of Cys242 of Human Monoacylglycerol Lipase Disrupts Balanced Hydrolysis of 1- and 2-Monoacylglycerols and Selectively Impairs Inhibitor Potency

  Tuomo Laitinen, Dina Navia-Paldanius, Roosa Rytilahti, Joona J. T. Marjamaa, Julie Kařízková, Teija Parkkari, Tatu Pantsar, Antti Poso, Jarmo T. Laitinen and Juha R. Savinainen

  Molecular Pharmacology March 2014, 85 (3) 510-519; DOI: https://doi.org/10.1124/mol.113.090795
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  Bcrp1;Mdr1a/b;Mrp2 Combination Knockout Mice: Altered Disposition of the Dietary Carcinogen PhIP (2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine) and Its Genotoxic Metabolites

  Maria L. H. Vlaming, Sebastiaan F. Teunissen, Evita van de Steeg, Anita van Esch, Els Wagenaar, Luc Brunsveld, Tom F. A. de Greef, Hilde Rosing, Jan H. M. Schellens, Jos H. Beijnen and Alfred H. Schinkel

  Molecular Pharmacology March 2014, 85 (3) 520-530; DOI: https://doi.org/10.1124/mol.113.088823