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Research ArticleArticle

Quantification of Ligand Bias for Clinically Relevant β2-Adrenergic Receptor Ligands: Implications for Drug Taxonomy

Emma T. van der Westhuizen, Billy Breton, Arthur Christopoulos and Michel Bouvier
Molecular Pharmacology March 2014, 85 (3) 492-509; DOI: https://doi.org/10.1124/mol.113.088880
Emma T. van der Westhuizen
Department of Biochemistry and Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec, Canada (E.T.v.d.W., B.B., M.B.); and Drug Discovery Biology and Department of Pharmacology, Monash Institute for Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia (E.T.v.d.W., A.C.)
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Billy Breton
Department of Biochemistry and Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec, Canada (E.T.v.d.W., B.B., M.B.); and Drug Discovery Biology and Department of Pharmacology, Monash Institute for Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia (E.T.v.d.W., A.C.)
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Arthur Christopoulos
Department of Biochemistry and Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec, Canada (E.T.v.d.W., B.B., M.B.); and Drug Discovery Biology and Department of Pharmacology, Monash Institute for Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia (E.T.v.d.W., A.C.)
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Michel Bouvier
Department of Biochemistry and Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec, Canada (E.T.v.d.W., B.B., M.B.); and Drug Discovery Biology and Department of Pharmacology, Monash Institute for Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia (E.T.v.d.W., A.C.)
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Article Information

vol. 85 no. 3 492-509
DOI 
https://doi.org/10.1124/mol.113.088880
PubMed 
24366668

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 29, 2013
  • Accepted December 23, 2013
  • Published online January 28, 2014.

Article Versions

  • Earlier version (December 23, 2013 - 09:07).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Emma T. van der Westhuizen,
  2. Billy Breton,
  3. Arthur Christopoulos, and
  4. Michel Bouvier
  1. Department of Biochemistry and Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec, Canada (E.T.v.d.W., B.B., M.B.); and Drug Discovery Biology and Department of Pharmacology, Monash Institute for Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia (E.T.v.d.W., A.C.)
  1. Address correspondence to:
    Michel Bouvier, IRIC – Université de Montréal, C.P. 6128 Succursale Centre-Ville, Montreal, QC, Canada. E-mail: michel.bouvier{at}umontreal.ca
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Molecular Pharmacology: 85 (3)
Molecular Pharmacology
Vol. 85, Issue 3
1 Mar 2014
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Research ArticleArticle

β2AR Ligands Are Biased toward ERK1/2 Signaling

Emma T. van der Westhuizen, Billy Breton, Arthur Christopoulos and Michel Bouvier
Molecular Pharmacology March 1, 2014, 85 (3) 492-509; DOI: https://doi.org/10.1124/mol.113.088880

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Research ArticleArticle

β2AR Ligands Are Biased toward ERK1/2 Signaling

Emma T. van der Westhuizen, Billy Breton, Arthur Christopoulos and Michel Bouvier
Molecular Pharmacology March 1, 2014, 85 (3) 492-509; DOI: https://doi.org/10.1124/mol.113.088880
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