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Mutation of Cys242 of Human Monoacylglycerol Lipase Disrupts Balanced Hydrolysis of 1- and 2-Monoacylglycerols and Selectively Impairs Inhibitor Potency
Tuomo Laitinen, Dina Navia-Paldanius, Roosa Rytilahti, Joona J. T. Marjamaa, Julie Kařízková, Teija Parkkari, Tatu Pantsar, Antti Poso, Jarmo T. Laitinen and Juha R. Savinainen
Molecular Pharmacology March 2014, 85 (3) 510-519; DOI: https://doi.org/10.1124/mol.113.090795
Tuomo Laitinen
Institute of Biomedicine/Physiology, School of Medicine (D.N.-P., R.R., J.J.T.M., J.K., Te.P., J.T.L., J.R.S.), and School of Pharmacy (T.L., Ta.P., A.P.), Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
Dina Navia-Paldanius
Institute of Biomedicine/Physiology, School of Medicine (D.N.-P., R.R., J.J.T.M., J.K., Te.P., J.T.L., J.R.S.), and School of Pharmacy (T.L., Ta.P., A.P.), Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
Roosa Rytilahti
Institute of Biomedicine/Physiology, School of Medicine (D.N.-P., R.R., J.J.T.M., J.K., Te.P., J.T.L., J.R.S.), and School of Pharmacy (T.L., Ta.P., A.P.), Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
Joona J. T. Marjamaa
Institute of Biomedicine/Physiology, School of Medicine (D.N.-P., R.R., J.J.T.M., J.K., Te.P., J.T.L., J.R.S.), and School of Pharmacy (T.L., Ta.P., A.P.), Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
Julie Kařízková
Institute of Biomedicine/Physiology, School of Medicine (D.N.-P., R.R., J.J.T.M., J.K., Te.P., J.T.L., J.R.S.), and School of Pharmacy (T.L., Ta.P., A.P.), Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
Teija Parkkari
Institute of Biomedicine/Physiology, School of Medicine (D.N.-P., R.R., J.J.T.M., J.K., Te.P., J.T.L., J.R.S.), and School of Pharmacy (T.L., Ta.P., A.P.), Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
Tatu Pantsar
Institute of Biomedicine/Physiology, School of Medicine (D.N.-P., R.R., J.J.T.M., J.K., Te.P., J.T.L., J.R.S.), and School of Pharmacy (T.L., Ta.P., A.P.), Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
Antti Poso
Institute of Biomedicine/Physiology, School of Medicine (D.N.-P., R.R., J.J.T.M., J.K., Te.P., J.T.L., J.R.S.), and School of Pharmacy (T.L., Ta.P., A.P.), Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
Jarmo T. Laitinen
Institute of Biomedicine/Physiology, School of Medicine (D.N.-P., R.R., J.J.T.M., J.K., Te.P., J.T.L., J.R.S.), and School of Pharmacy (T.L., Ta.P., A.P.), Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
Juha R. Savinainen
Institute of Biomedicine/Physiology, School of Medicine (D.N.-P., R.R., J.J.T.M., J.K., Te.P., J.T.L., J.R.S.), and School of Pharmacy (T.L., Ta.P., A.P.), Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
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Structural Determinants of MAGL for Substrate Preference
Tuomo Laitinen, Dina Navia-Paldanius, Roosa Rytilahti, Joona J. T. Marjamaa, Julie Kařízková, Teija Parkkari, Tatu Pantsar, Antti Poso, Jarmo T. Laitinen and Juha R. Savinainen
Molecular Pharmacology March 1, 2014, 85 (3) 510-519; DOI: https://doi.org/10.1124/mol.113.090795
Research ArticleArticle
Structural Determinants of MAGL for Substrate Preference
Tuomo Laitinen, Dina Navia-Paldanius, Roosa Rytilahti, Joona J. T. Marjamaa, Julie Kařízková, Teija Parkkari, Tatu Pantsar, Antti Poso, Jarmo T. Laitinen and Juha R. Savinainen
Molecular Pharmacology March 1, 2014, 85 (3) 510-519; DOI: https://doi.org/10.1124/mol.113.090795
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