Advertisement
Research ArticleArticle

Observed Drug-Receptor Association Rates Are Governed by Membrane Affinity: The Importance of Establishing “Micro-Pharmacokinetic/Pharmacodynamic Relationships” at the β2-Adrenoceptor

David A. Sykes, Cheryl Parry, John Reilly, Penny Wright, Robin A. Fairhurst and Steven J. Charlton
Molecular Pharmacology April 2014, 85 (4) 608-617; DOI: https://doi.org/10.1124/mol.113.090209

Article Information

vol. 85 no. 4 608-617
DOI 
https://doi.org/10.1124/mol.113.090209
PubMed 
24476583
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received October 11, 2013
  • Accepted January 28, 2014
  • Published online February 21, 2014.

Article Versions

Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. David A. Sykes,
  2. Cheryl Parry,
  3. John Reilly,
  4. Penny Wright,
  5. Robin A. Fairhurst, and
  6. Steven J. Charlton
  1. Novartis Institutes for Biomedical Research: Horsham, West Sussex, United Kingdom (D.A.S., C.P., P.W., S.J.C.), Cambridge, Massachusetts (J.R.), and Basel, Switzerland (R.A.F.)
  1. Address correspondence to:
    Dr. Steven J. Charlton, Novartis Institutes for Biomedical Sciences, Wimblehurst Road, Horsham, West Sussex, RH12 5AB, United Kingdom. E-mail: steven.charlton{at}novartis.com
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: January 2014 to September 2024

AbstractFullPdf
Jan 201476023
Feb 201434917102
Mar 20143902079
Apr 20141331543
May 2014692280
Jun 2014561338
Jul 20143287
Aug 2014302315
Sep 201432716
Oct 2014371611
Nov 201438158
Dec 2014181114
Jan 2015401414
Feb 2015261730
Mar 2015141621
Apr 2015344032
May 2015272517
Jun 2015392422
Jul 2015462334
Aug 2015321825
Sep 2015191830
Oct 2015192622
Nov 2015241733
Dec 20156924
Jan 2016221727
Feb 2016151116
Mar 2016181831
Apr 2016292233
May 2016132554
Jun 2016233155
Jul 2016101822
Aug 2016202422
Sep 2016292124
Oct 201643014
Nov 201642617
Dec 201612510
Jan 201723819
Feb 201713925
Mar 201743422
Apr 201761818
May 201762533
Jun 201712222
Jul 201721627
Aug 201782848
Sep 201712829
Oct 201722936
Nov 201724034
Dec 201723022
Jan 201824718
Feb 201853225
Mar 201823125
Apr 201844629
May 201862625
Jun 201812218
Jul 201843131
Aug 201852525
Sep 201842128
Oct 201832636
Nov 201842834
Dec 201872641
Jan 201933722
Feb 2019181228
Mar 201973930
Apr 2019271519
May 201920617
Jun 201935622
Jul 201934910
Aug 201951921
Sep 201949926
Oct 2019451025
Nov 2019392418
Dec 2019161616
Jan 202032233
Feb 2020121416
Mar 2020561022
Apr 2020107526
May 2020811121
Jun 202058510
Jul 202034316
Aug 202047515
Sep 2020691130
Oct 202026521
Nov 202021512
Dec 202026915
Jan 2021381318
Feb 2021451025
Mar 202143106
Apr 20214429
May 2021491110
Jun 2021411317
Jul 202138816
Aug 2021271620
Sep 2021711313
Oct 202136811
Nov 2021571116
Dec 2021431118
Jan 2022791411
Feb 202234514
Mar 2022801420
Apr 202238815
May 202229924
Jun 2022431224
Jul 2022281117
Aug 202232512
Sep 202245127
Oct 20225589
Nov 202266814
Dec 20225755
Jan 202326710
Feb 20232175
Mar 2023281614
Apr 2023482418
May 202337127
Jun 20233136
Jul 2023471411
Aug 202347511
Sep 20233076
Oct 202322106
Nov 2023129512
Dec 202350130
Jan 20245175
Feb 202427104
Mar 2024711417
Apr 20245699
May 20247067
Jun 202446213
Jul 202447125
Aug 202464147
Sep 20242061

Back to top

In this issue

Download PDF
Article Alerts
Email Article
Citation Tools

Research ArticleArticle

Establishing “Micro PK/PD” at the β2-Adrenoceptor

David A. Sykes, Cheryl Parry, John Reilly, Penny Wright, Robin A. Fairhurst and Steven J. Charlton
Molecular Pharmacology April 1, 2014, 85 (4) 608-617; DOI: https://doi.org/10.1124/mol.113.090209
Twitter logo Facebook logo Mendeley logo

Jump to section

Advertisement