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Observed Drug-Receptor Association Rates Are Governed by Membrane Affinity: The Importance of Establishing “Micro-Pharmacokinetic/Pharmacodynamic Relationships” at the β2-Adrenoceptor

David A. Sykes, Cheryl Parry, John Reilly, Penny Wright, Robin A. Fairhurst and Steven J. Charlton
Molecular Pharmacology April 2014, 85 (4) 608-617; DOI: https://doi.org/10.1124/mol.113.090209

Article Information

vol. 85 no. 4 608-617
DOI 
https://doi.org/10.1124/mol.113.090209
PubMed 
24476583
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received October 11, 2013
  • Accepted January 28, 2014
  • Published online February 21, 2014.

Article Versions

Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. David A. Sykes,
  2. Cheryl Parry,
  3. John Reilly,
  4. Penny Wright,
  5. Robin A. Fairhurst, and
  6. Steven J. Charlton
  1. Novartis Institutes for Biomedical Research: Horsham, West Sussex, United Kingdom (D.A.S., C.P., P.W., S.J.C.), Cambridge, Massachusetts (J.R.), and Basel, Switzerland (R.A.F.)
  1. Address correspondence to:
    Dr. Steven J. Charlton, Novartis Institutes for Biomedical Sciences, Wimblehurst Road, Horsham, West Sussex, RH12 5AB, United Kingdom. E-mail: steven.charlton{at}novartis.com
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Research ArticleArticle

Establishing “Micro PK/PD” at the β2-Adrenoceptor

David A. Sykes, Cheryl Parry, John Reilly, Penny Wright, Robin A. Fairhurst and Steven J. Charlton
Molecular Pharmacology April 1, 2014, 85 (4) 608-617; DOI: https://doi.org/10.1124/mol.113.090209
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