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Molecular Pharmacology

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Table of Contents

May 01, 2014; Volume 85,Issue 5

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    Molecular Responses to Hypoxia-Inducible Factor 1α and Beyond
    Jason Brocato, Yana Chervona and Max Costa
    Molecular Pharmacology May 2014, 85 (5) 651-657; DOI: https://doi.org/10.1124/mol.113.089623

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    The Noradrenergic Component in Tapentadol Action Counteracts μ-Opioid Receptor–Mediated Adverse Effects on Adult Neurogenesis
    Vasco Meneghini, Bruna Cuccurazzu, Valeria Bortolotto, Vera Ramazzotti, Federica Ubezio, Thomas M. Tzschentke, Pier Luigi Canonico and Mariagrazia Grilli
    Molecular Pharmacology May 2014, 85 (5) 658-670; DOI: https://doi.org/10.1124/mol.113.091520
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    Influence of the N Terminus on the Biophysical Properties and Pharmacology of TREK1 Potassium Channels
    Emma L. Veale, Ehab Al-Moubarak, Naina Bajaria, Kiyoyuki Omoto, Lishuang Cao, Stephen J. Tucker, Edward B. Stevens and Alistair Mathie
    Molecular Pharmacology May 2014, 85 (5) 671-681; DOI: https://doi.org/10.1124/mol.113.091199
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    Activating Transcription Factor 3 Protects against Pressure-Overload Heart Failure via the Autophagy Molecule Beclin-1 Pathway
    Heng Lin, Hsiao-Fen Li, Hsi-Hsien Chen, Pei-Fang Lai, Shu-Hui Juan, Jin-Jer Chen and Ching-Feng Cheng
    Molecular Pharmacology May 2014, 85 (5) 682-691; DOI: https://doi.org/10.1124/mol.113.090092
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    Block of Human Cardiac Sodium Channels by Lacosamide: Evidence for Slow Drug Binding along the Activation Pathway
    Ging Kuo Wang and Sho-Ya Wang
    Molecular Pharmacology May 2014, 85 (5) 692-702; DOI: https://doi.org/10.1124/mol.113.091173
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    Molecular Basis for Selective Serotonin Reuptake Inhibition by the Antidepressant Agent Fluoxetine (Prozac)
    Jacob Andersen, Nicolai Stuhr-Hansen, Linda Grønborg Zachariassen, Heidi Koldsø, Birgit Schiøtt, Kristian Strømgaard and Anders S. Kristensen
    Molecular Pharmacology May 2014, 85 (5) 703-714; DOI: https://doi.org/10.1124/mol.113.091249
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    Renal Circadian Clock Regulates the Dosing-Time Dependency of Cisplatin-Induced Nephrotoxicity in Mice
    Masayuki Oda, Satoru Koyanagi, Yuuya Tsurudome, Takumi Kanemitsu, Naoya Matsunaga and Shigehiro Ohdo
    Molecular Pharmacology May 2014, 85 (5) 715-722; DOI: https://doi.org/10.1124/mol.113.089805
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    Context-Dependent Antagonism between Akt Inhibitors and Topoisomerase Poisons
    Marina Gálvez-Peralta, Karen S. Flatten, David A. Loegering, Kevin L. Peterson, Paula A. Schneider, Charles Erlichman and Scott H. Kaufmann
    Molecular Pharmacology May 2014, 85 (5) 723-734; DOI: https://doi.org/10.1124/mol.113.088674
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    Identifying Barbiturate Binding Sites in a Nicotinic Acetylcholine Receptor with [3H]Allyl m-Trifluoromethyldiazirine Mephobarbital, a Photoreactive Barbiturate
    Ayman K. Hamouda, Deirdre S. Stewart, David C. Chiara, Pavel Y. Savechenkov, Karol S. Bruzik and Jonathan B. Cohen
    Molecular Pharmacology May 2014, 85 (5) 735-746; DOI: https://doi.org/10.1124/mol.113.090985
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    Morphine Induces Redox-Based Changes in Global DNA Methylation and Retrotransposon Transcription by Inhibition of Excitatory Amino Acid Transporter Type 3–Mediated Cysteine Uptake
    Malav Trivedi, Jayni Shah, Nathaniel Hodgson, Hyang-Min Byun and Richard Deth
    Molecular Pharmacology May 2014, 85 (5) 747-757; DOI: https://doi.org/10.1124/mol.114.091728
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    Differential Effects of the Gβ5-RGS7 Complex on Muscarinic M3 Receptor–Induced Ca2+ Influx and Release
    Darla Karpinsky-Semper, Claude-Henry Volmar, Shaun P. Brothers and Vladlen Z. Slepak
    Molecular Pharmacology May 2014, 85 (5) 758-768; DOI: https://doi.org/10.1124/mol.114.091843
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    Kinetics of Drug Interaction with the Kv11.1 Potassium Channel
    Adam P. Hill, Mark J. Perrin, Juliane Heide, Terence J. Campbell, Stefan A. Mann and Jamie I. Vandenberg
    Molecular Pharmacology May 2014, 85 (5) 769-776; DOI: https://doi.org/10.1124/mol.114.091835
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    Microbiome-Derived Tryptophan Metabolites and Their Aryl Hydrocarbon Receptor-Dependent Agonist and Antagonist Activities
    Un-Ho Jin, Syng-Ook Lee, Gautham Sridharan, Kyongbum Lee, Laurie A. Davidson, Arul Jayaraman, Robert S. Chapkin, Robert Alaniz and Stephen Safe
    Molecular Pharmacology May 2014, 85 (5) 777-788; DOI: https://doi.org/10.1124/mol.113.091165
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    Defining the Conformation of the Estrogen Receptor Complex That Controls Estrogen-Induced Apoptosis in Breast Cancer
    Ifeyinwa Obiorah, Surojeet Sengupta, Ramona Curpan and V. Craig Jordan
    Molecular Pharmacology May 2014, 85 (5) 789-799; DOI: https://doi.org/10.1124/mol.113.089250
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    Overexpression of Diacylglycerol Kinase η Enhances Gαq-Coupled G Protein–Coupled Receptor Signaling
    Joseph E. Rittiner, Victoria E. Brings and Mark J. Zylka
    Molecular Pharmacology May 2014, 85 (5) 800-810; DOI: https://doi.org/10.1124/mol.113.091280
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    Identification of Key Residues in Transmembrane 4 Responsible for the Secondary, Low-Affinity Conformation of the Human β1-Adrenoceptor
    Jillian G. Baker, Richard G. W. Proudman and Stephen J. Hill
    Molecular Pharmacology May 2014, 85 (5) 811-829; DOI: https://doi.org/10.1124/mol.114.091587
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In this issue

Molecular Pharmacology: 85 (5)
Molecular Pharmacology
Vol. 85, Issue 5
1 May 2014
  • Table of Contents
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  • SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
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  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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