Table of Contents

Articles

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  The Noradrenergic Component in Tapentadol Action Counteracts μ-Opioid Receptor–Mediated Adverse Effects on Adult Neurogenesis

  Vasco Meneghini, Bruna Cuccurazzu, Valeria Bortolotto, Vera Ramazzotti, Federica Ubezio, Thomas M. Tzschentke, Pier Luigi Canonico and Mariagrazia Grilli

  Molecular Pharmacology May 2014, 85 (5) 658-670; DOI: https://doi.org/10.1124/mol.113.091520
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  Influence of the N Terminus on the Biophysical Properties and Pharmacology of TREK1 Potassium Channels

  Emma L. Veale, Ehab Al-Moubarak, Naina Bajaria, Kiyoyuki Omoto, Lishuang Cao, Stephen J. Tucker, Edward B. Stevens and Alistair Mathie

  Molecular Pharmacology May 2014, 85 (5) 671-681; DOI: https://doi.org/10.1124/mol.113.091199
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  Activating Transcription Factor 3 Protects against Pressure-Overload Heart Failure via the Autophagy Molecule Beclin-1 Pathway

  Heng Lin, Hsiao-Fen Li, Hsi-Hsien Chen, Pei-Fang Lai, Shu-Hui Juan, Jin-Jer Chen and Ching-Feng Cheng

  Molecular Pharmacology May 2014, 85 (5) 682-691; DOI: https://doi.org/10.1124/mol.113.090092
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  Block of Human Cardiac Sodium Channels by Lacosamide: Evidence for Slow Drug Binding along the Activation Pathway

  Ging Kuo Wang and Sho-Ya Wang

  Molecular Pharmacology May 2014, 85 (5) 692-702; DOI: https://doi.org/10.1124/mol.113.091173
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  Molecular Basis for Selective Serotonin Reuptake Inhibition by the Antidepressant Agent Fluoxetine (Prozac)

  Jacob Andersen, Nicolai Stuhr-Hansen, Linda Grønborg Zachariassen, Heidi Koldsø, Birgit Schiøtt, Kristian Strømgaard and Anders S. Kristensen

  Molecular Pharmacology May 2014, 85 (5) 703-714; DOI: https://doi.org/10.1124/mol.113.091249
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  Renal Circadian Clock Regulates the Dosing-Time Dependency of Cisplatin-Induced Nephrotoxicity in Mice

  Masayuki Oda, Satoru Koyanagi, Yuuya Tsurudome, Takumi Kanemitsu, Naoya Matsunaga and Shigehiro Ohdo

  Molecular Pharmacology May 2014, 85 (5) 715-722; DOI: https://doi.org/10.1124/mol.113.089805
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  Context-Dependent Antagonism between Akt Inhibitors and Topoisomerase Poisons

  Marina Gálvez-Peralta, Karen S. Flatten, David A. Loegering, Kevin L. Peterson, Paula A. Schneider, Charles Erlichman and Scott H. Kaufmann

  Molecular Pharmacology May 2014, 85 (5) 723-734; DOI: https://doi.org/10.1124/mol.113.088674
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  Identifying Barbiturate Binding Sites in a Nicotinic Acetylcholine Receptor with [³H]Allyl m-Trifluoromethyldiazirine Mephobarbital, a Photoreactive Barbiturate

  Ayman K. Hamouda, Deirdre S. Stewart, David C. Chiara, Pavel Y. Savechenkov, Karol S. Bruzik and Jonathan B. Cohen

  Molecular Pharmacology May 2014, 85 (5) 735-746; DOI: https://doi.org/10.1124/mol.113.090985
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  Morphine Induces Redox-Based Changes in Global DNA Methylation and Retrotransposon Transcription by Inhibition of Excitatory Amino Acid Transporter Type 3–Mediated Cysteine Uptake

  Malav Trivedi, Jayni Shah, Nathaniel Hodgson, Hyang-Min Byun and Richard Deth

  Molecular Pharmacology May 2014, 85 (5) 747-757; DOI: https://doi.org/10.1124/mol.114.091728
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  Differential Effects of the Gβ5-RGS7 Complex on Muscarinic M3 Receptor–Induced Ca²⁺ Influx and Release

  Darla Karpinsky-Semper, Claude-Henry Volmar, Shaun P. Brothers and Vladlen Z. Slepak

  Molecular Pharmacology May 2014, 85 (5) 758-768; DOI: https://doi.org/10.1124/mol.114.091843
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  Kinetics of Drug Interaction with the K_v11.1 Potassium Channel

  Adam P. Hill, Mark J. Perrin, Juliane Heide, Terence J. Campbell, Stefan A. Mann and Jamie I. Vandenberg

  Molecular Pharmacology May 2014, 85 (5) 769-776; DOI: https://doi.org/10.1124/mol.114.091835
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  Microbiome-Derived Tryptophan Metabolites and Their Aryl Hydrocarbon Receptor-Dependent Agonist and Antagonist Activities

  Un-Ho Jin, Syng-Ook Lee, Gautham Sridharan, Kyongbum Lee, Laurie A. Davidson, Arul Jayaraman, Robert S. Chapkin, Robert Alaniz and Stephen Safe

  Molecular Pharmacology May 2014, 85 (5) 777-788; DOI: https://doi.org/10.1124/mol.113.091165
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  Defining the Conformation of the Estrogen Receptor Complex That Controls Estrogen-Induced Apoptosis in Breast Cancer

  Ifeyinwa Obiorah, Surojeet Sengupta, Ramona Curpan and V. Craig Jordan

  Molecular Pharmacology May 2014, 85 (5) 789-799; DOI: https://doi.org/10.1124/mol.113.089250
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  Overexpression of Diacylglycerol Kinase η Enhances Gα_q-Coupled G Protein–Coupled Receptor Signaling

  Joseph E. Rittiner, Victoria E. Brings and Mark J. Zylka

  Molecular Pharmacology May 2014, 85 (5) 800-810; DOI: https://doi.org/10.1124/mol.113.091280
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  Identification of Key Residues in Transmembrane 4 Responsible for the Secondary, Low-Affinity Conformation of the Human β₁-Adrenoceptor

  Jillian G. Baker, Richard G. W. Proudman and Stephen J. Hill

  Molecular Pharmacology May 2014, 85 (5) 811-829; DOI: https://doi.org/10.1124/mol.114.091587