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Research ArticleArticle

19-Substituted Benzoquinone Ansamycin Heat Shock Protein-90 Inhibitors: Biological Activity and Decreased Off-Target Toxicity

Chuan-Hsin Chang, Derek A. Drechsel, Russell R. A. Kitson, David Siegel, Qiang You, Donald S. Backos, Cynthia Ju, Christopher J. Moody and David Ross
Molecular Pharmacology June 2014, 85 (6) 849-857; DOI: https://doi.org/10.1124/mol.113.090654
Chuan-Hsin Chang
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (C.-H.C., D.A.D., D.S., Q.Y., D.S.B., C.J., D.R.); and School of Chemistry, University of Nottingham, Nottingham, United Kingdom (R.R.A.K., C.J.M.)
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Derek A. Drechsel
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (C.-H.C., D.A.D., D.S., Q.Y., D.S.B., C.J., D.R.); and School of Chemistry, University of Nottingham, Nottingham, United Kingdom (R.R.A.K., C.J.M.)
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Russell R. A. Kitson
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (C.-H.C., D.A.D., D.S., Q.Y., D.S.B., C.J., D.R.); and School of Chemistry, University of Nottingham, Nottingham, United Kingdom (R.R.A.K., C.J.M.)
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David Siegel
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (C.-H.C., D.A.D., D.S., Q.Y., D.S.B., C.J., D.R.); and School of Chemistry, University of Nottingham, Nottingham, United Kingdom (R.R.A.K., C.J.M.)
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Qiang You
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (C.-H.C., D.A.D., D.S., Q.Y., D.S.B., C.J., D.R.); and School of Chemistry, University of Nottingham, Nottingham, United Kingdom (R.R.A.K., C.J.M.)
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Donald S. Backos
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (C.-H.C., D.A.D., D.S., Q.Y., D.S.B., C.J., D.R.); and School of Chemistry, University of Nottingham, Nottingham, United Kingdom (R.R.A.K., C.J.M.)
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Cynthia Ju
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (C.-H.C., D.A.D., D.S., Q.Y., D.S.B., C.J., D.R.); and School of Chemistry, University of Nottingham, Nottingham, United Kingdom (R.R.A.K., C.J.M.)
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Christopher J. Moody
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (C.-H.C., D.A.D., D.S., Q.Y., D.S.B., C.J., D.R.); and School of Chemistry, University of Nottingham, Nottingham, United Kingdom (R.R.A.K., C.J.M.)
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David Ross
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (C.-H.C., D.A.D., D.S., Q.Y., D.S.B., C.J., D.R.); and School of Chemistry, University of Nottingham, Nottingham, United Kingdom (R.R.A.K., C.J.M.)
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Molecular Pharmacology: 85 (6)
Molecular Pharmacology
Vol. 85, Issue 6
1 Jun 2014
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Research ArticleArticle

Novel Hsp90 Inhibitors with Decreased Off-Target Toxicity

Chuan-Hsin Chang, Derek A. Drechsel, Russell R. A. Kitson, David Siegel, Qiang You, Donald S. Backos, Cynthia Ju, Christopher J. Moody and David Ross
Molecular Pharmacology June 1, 2014, 85 (6) 849-857; DOI: https://doi.org/10.1124/mol.113.090654

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Research ArticleArticle

Novel Hsp90 Inhibitors with Decreased Off-Target Toxicity

Chuan-Hsin Chang, Derek A. Drechsel, Russell R. A. Kitson, David Siegel, Qiang You, Donald S. Backos, Cynthia Ju, Christopher J. Moody and David Ross
Molecular Pharmacology June 1, 2014, 85 (6) 849-857; DOI: https://doi.org/10.1124/mol.113.090654
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