Development of a Radioligand, [3H]LY2119620, to Probe the Human M2 and M4 Muscarinic Receptor Allosteric Binding Sites

Douglas A. Schober; Carrie H. Croy; Hongling Xiao; Arthur Christopoulos; Christian C. Felder

doi:10.1124/mol.114.091785

Research ArticleArticle

Development of a Radioligand, [³H]LY2119620, to Probe the Human M₂ and M₄ Muscarinic Receptor Allosteric Binding Sites

Douglas A. Schober, Carrie H. Croy, Hongling Xiao, Arthur Christopoulos and Christian C. Felder

Molecular Pharmacology July 2014, 86 (1) 116-123; DOI: https://doi.org/10.1124/mol.114.091785

Douglas A. Schober

Lilly Neuroscience, Lilly Research Laboratories, Eli Lilly and Co., Lilly Corporate Center, Indianapolis, Indiana (D.A.S., C.H.C., H.X., C.C.F.); and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia (A.C.)

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Carrie H. Croy

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Hongling Xiao

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Arthur Christopoulos

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Christian C. Felder

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Molecular Pharmacology

Vol. 86, Issue 1

1 Jul 2014

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Research ArticleArticle

[³H]LY2119620, a Novel M₂ and M₄ mAChR Allosteric Probe

Douglas A. Schober, Carrie H. Croy, Hongling Xiao, Arthur Christopoulos and Christian C. Felder

Molecular Pharmacology July 1, 2014, 86 (1) 116-123; DOI: https://doi.org/10.1124/mol.114.091785

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Research ArticleArticle

[³H]LY2119620, a Novel M₂ and M₄ mAChR Allosteric Probe

Douglas A. Schober, Carrie H. Croy, Hongling Xiao, Arthur Christopoulos and Christian C. Felder

Molecular Pharmacology July 1, 2014, 86 (1) 116-123; DOI: https://doi.org/10.1124/mol.114.091785

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[³H]LY2119620, a Novel M₂ and M₄ mAChR Allosteric Probe