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Research ArticleArticle

Regulation of Human CYP2C9 Expression by Electrophilic Stress Involves Activator Protein 1 Activation and DNA Looping

Ngome L. Makia, Sailesh Surapureddi, Katalin Monostory, Russell A. Prough and Joyce A. Goldstein
Molecular Pharmacology August 2014, 86 (2) 125-137; DOI: https://doi.org/10.1124/mol.114.092585
Ngome L. Makia
Human Metabolism Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina (N.L.M., S.S., J.A.G.); Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky (R.A.P.); and Research Centre for Natural Sciences, Hungarian Academy of Science, Budapest, Hungary (K.M.)
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Sailesh Surapureddi
Human Metabolism Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina (N.L.M., S.S., J.A.G.); Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky (R.A.P.); and Research Centre for Natural Sciences, Hungarian Academy of Science, Budapest, Hungary (K.M.)
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Katalin Monostory
Human Metabolism Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina (N.L.M., S.S., J.A.G.); Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky (R.A.P.); and Research Centre for Natural Sciences, Hungarian Academy of Science, Budapest, Hungary (K.M.)
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Russell A. Prough
Human Metabolism Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina (N.L.M., S.S., J.A.G.); Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky (R.A.P.); and Research Centre for Natural Sciences, Hungarian Academy of Science, Budapest, Hungary (K.M.)
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Joyce A. Goldstein
Human Metabolism Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina (N.L.M., S.S., J.A.G.); Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky (R.A.P.); and Research Centre for Natural Sciences, Hungarian Academy of Science, Budapest, Hungary (K.M.)
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Article Information

vol. 86 no. 2 125-137
DOI 
https://doi.org/10.1124/mol.114.092585
PubMed 
24830941

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received March 7, 2014
  • Accepted May 14, 2014
  • Published online June 26, 2014.

Article Versions

  • Earlier version (May 15, 2014 - 09:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
U.S. Government work not protected by U.S. copyright

Author Information

  1. Ngome L. Makia,
  2. Sailesh Surapureddi,
  3. Katalin Monostory,
  4. Russell A. Prough, and
  5. Joyce A. Goldstein
  1. Human Metabolism Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina (N.L.M., S.S., J.A.G.); Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky (R.A.P.); and Research Centre for Natural Sciences, Hungarian Academy of Science, Budapest, Hungary (K.M.)
  1. Address correspondence to:
    Dr. Joyce A. Goldstein, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, Building 101, P.O. Box 12233, Research Triangle Park, NC 27709. E-mail: goldste1{at}niehs.nih.gov
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Molecular Pharmacology: 86 (2)
Molecular Pharmacology
Vol. 86, Issue 2
1 Aug 2014
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Research ArticleArticle

Regulation of CYP2C9 by AP-1 Activation and DNA Looping

Ngome L. Makia, Sailesh Surapureddi, Katalin Monostory, Russell A. Prough and Joyce A. Goldstein
Molecular Pharmacology August 1, 2014, 86 (2) 125-137; DOI: https://doi.org/10.1124/mol.114.092585

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Research ArticleArticle

Regulation of CYP2C9 by AP-1 Activation and DNA Looping

Ngome L. Makia, Sailesh Surapureddi, Katalin Monostory, Russell A. Prough and Joyce A. Goldstein
Molecular Pharmacology August 1, 2014, 86 (2) 125-137; DOI: https://doi.org/10.1124/mol.114.092585
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