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Rapid CommunicationMinireview—Special Section on Highlights from IUPHAR

Analyses of CD20 Monoclonal Antibody–Mediated Tumor Cell Killing Mechanisms: Rational Design of Dosing Strategies

Ronald P. Taylor and Margaret A. Lindorfer
Molecular Pharmacology November 2014, 86 (5) 485-491; DOI: https://doi.org/10.1124/mol.114.092684
Ronald P. Taylor
Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia
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Margaret A. Lindorfer
Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia
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Article Information

vol. 86 no. 5 485-491
DOI 
https://doi.org/10.1124/mol.114.092684
PubMed 
24944188

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received March 12, 2014
  • Accepted June 18, 2014
  • Published online September 25, 2014.

Article Versions

  • Earlier version (June 18, 2014 - 09:30).
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Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ronald P. Taylor and
  2. Margaret A. Lindorfer
  1. Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia
  1. Address correspondence to:
    Ronald P. Taylor, Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, 1340 Jefferson Park Avenue, Box 800733, Charlottesville, VA 22908. E-mail: rpt{at}virginia.edu
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Molecular Pharmacology: 86 (5)
Molecular Pharmacology
Vol. 86, Issue 5
1 Nov 2014
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Rapid CommunicationMinireview—Special Section on Highlights from IUPHAR

Optimizing Doses for Monoclonal Antibodies in Cancer

Ronald P. Taylor and Margaret A. Lindorfer
Molecular Pharmacology November 1, 2014, 86 (5) 485-491; DOI: https://doi.org/10.1124/mol.114.092684

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Rapid CommunicationMinireview—Special Section on Highlights from IUPHAR

Optimizing Doses for Monoclonal Antibodies in Cancer

Ronald P. Taylor and Margaret A. Lindorfer
Molecular Pharmacology November 1, 2014, 86 (5) 485-491; DOI: https://doi.org/10.1124/mol.114.092684
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  • Article
    • Abstract
    • Introduction
    • Correlative Studies Associated with CD20 mAb Treatment of CLL
    • Trogocytosis of mAb-Opsonized Cells
    • The Importance of Exhaustion
    • Possible Generalization to Other Immunotherapeutic mAbs
    • Quantitative Considerations
    • Concluding Remarks: The Way Forward
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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