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Research ArticleArticle

Krüppel-Like Factor 9 Promotes Hepatic Cytochrome P450 2D6 Expression during Pregnancy in CYP2D6-Humanized Mice

Kwi Hye Koh, Xian Pan, Wei Zhang, Alan McLachlan, Raul Urrutia and Hyunyoung Jeong
Molecular Pharmacology December 2014, 86 (6) 727-735; DOI: https://doi.org/10.1124/mol.114.093666
Kwi Hye Koh
Department of Pharmacy Practice (K.H.K., H.J.), Department of Biopharmaceutical Sciences (X.P., H.J.), College of Pharmacy, and Department of Pediatrics (W.Z.) and Department of Microbiology and Immunology (A.M.), College of Medicine, University of Illinois at Chicago, Chicago, Illinois; and Laboratory of Epigenetics and Chromatin Dynamics, and Departments of Biology and Molecular Biology, Epigenomics Translational Program, Mayo Clinic Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota (R.U.)
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Xian Pan
Department of Pharmacy Practice (K.H.K., H.J.), Department of Biopharmaceutical Sciences (X.P., H.J.), College of Pharmacy, and Department of Pediatrics (W.Z.) and Department of Microbiology and Immunology (A.M.), College of Medicine, University of Illinois at Chicago, Chicago, Illinois; and Laboratory of Epigenetics and Chromatin Dynamics, and Departments of Biology and Molecular Biology, Epigenomics Translational Program, Mayo Clinic Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota (R.U.)
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Wei Zhang
Department of Pharmacy Practice (K.H.K., H.J.), Department of Biopharmaceutical Sciences (X.P., H.J.), College of Pharmacy, and Department of Pediatrics (W.Z.) and Department of Microbiology and Immunology (A.M.), College of Medicine, University of Illinois at Chicago, Chicago, Illinois; and Laboratory of Epigenetics and Chromatin Dynamics, and Departments of Biology and Molecular Biology, Epigenomics Translational Program, Mayo Clinic Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota (R.U.)
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Alan McLachlan
Department of Pharmacy Practice (K.H.K., H.J.), Department of Biopharmaceutical Sciences (X.P., H.J.), College of Pharmacy, and Department of Pediatrics (W.Z.) and Department of Microbiology and Immunology (A.M.), College of Medicine, University of Illinois at Chicago, Chicago, Illinois; and Laboratory of Epigenetics and Chromatin Dynamics, and Departments of Biology and Molecular Biology, Epigenomics Translational Program, Mayo Clinic Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota (R.U.)
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Raul Urrutia
Department of Pharmacy Practice (K.H.K., H.J.), Department of Biopharmaceutical Sciences (X.P., H.J.), College of Pharmacy, and Department of Pediatrics (W.Z.) and Department of Microbiology and Immunology (A.M.), College of Medicine, University of Illinois at Chicago, Chicago, Illinois; and Laboratory of Epigenetics and Chromatin Dynamics, and Departments of Biology and Molecular Biology, Epigenomics Translational Program, Mayo Clinic Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota (R.U.)
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Hyunyoung Jeong
Department of Pharmacy Practice (K.H.K., H.J.), Department of Biopharmaceutical Sciences (X.P., H.J.), College of Pharmacy, and Department of Pediatrics (W.Z.) and Department of Microbiology and Immunology (A.M.), College of Medicine, University of Illinois at Chicago, Chicago, Illinois; and Laboratory of Epigenetics and Chromatin Dynamics, and Departments of Biology and Molecular Biology, Epigenomics Translational Program, Mayo Clinic Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota (R.U.)
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Article Information

vol. 86 no. 6 727-735
DOI 
https://doi.org/10.1124/mol.114.093666
PubMed 
25217496

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received May 7, 2014
  • Accepted September 12, 2014
  • Published online November 13, 2014.

Article Versions

  • Earlier version (September 12, 2014 - 11:38).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kwi Hye Koh,
  2. Xian Pan,
  3. Wei Zhang,
  4. Alan McLachlan,
  5. Raul Urrutia, and
  6. Hyunyoung Jeong
  1. Department of Pharmacy Practice (K.H.K., H.J.), Department of Biopharmaceutical Sciences (X.P., H.J.), College of Pharmacy, and Department of Pediatrics (W.Z.) and Department of Microbiology and Immunology (A.M.), College of Medicine, University of Illinois at Chicago, Chicago, Illinois; and Laboratory of Epigenetics and Chromatin Dynamics, and Departments of Biology and Molecular Biology, Epigenomics Translational Program, Mayo Clinic Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota (R.U.)
  1. Address correspondence to:
    Hyunyoung Jeong, Department of Pharmacy Practice (MC 886), University of Illinois at Chicago, 833 S. Wood Street, Chicago, IL 60612. E-mail: yjeong{at}uic.edu
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Molecular Pharmacology: 86 (6)
Molecular Pharmacology
Vol. 86, Issue 6
1 Dec 2014
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Research ArticleArticle

Role of KLF9 in CYP2D6 Induction during Pregnancy

Kwi Hye Koh, Xian Pan, Wei Zhang, Alan McLachlan, Raul Urrutia and Hyunyoung Jeong
Molecular Pharmacology December 1, 2014, 86 (6) 727-735; DOI: https://doi.org/10.1124/mol.114.093666

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Research ArticleArticle

Role of KLF9 in CYP2D6 Induction during Pregnancy

Kwi Hye Koh, Xian Pan, Wei Zhang, Alan McLachlan, Raul Urrutia and Hyunyoung Jeong
Molecular Pharmacology December 1, 2014, 86 (6) 727-735; DOI: https://doi.org/10.1124/mol.114.093666
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