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Research ArticleArticle

P-Retigabine: An N-Propargyled Retigabine with Improved Brain Distribution and Enhanced Antiepileptic Activity

Pingzheng Zhou, Yangming Zhang, Haiyan Xu, Fei Chen, Xueqin Chen, Xiaoying Li, Xiaoping Pi, Lipeng Wang, Li Zhan, Fajun Nan and Zhaobing Gao
Molecular Pharmacology January 2015, 87 (1) 31-38; DOI: https://doi.org/10.1124/mol.114.095190
Pingzheng Zhou
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Yangming Zhang
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Haiyan Xu
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Fei Chen
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Xueqin Chen
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Xiaoying Li
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Xiaoping Pi
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Lipeng Wang
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Li Zhan
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Fajun Nan
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Zhaobing Gao
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Article Information

vol. 87 no. 1 31-38
DOI 
https://doi.org/10.1124/mol.114.095190
PubMed 
25319542

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received August 11, 2014
  • Accepted October 15, 2014
  • Published online November 19, 2014.

Article Versions

  • Earlier version (October 15, 2014 - 08:13).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Pingzheng Zhou,
  2. Yangming Zhang,
  3. Haiyan Xu,
  4. Fei Chen,
  5. Xueqin Chen,
  6. Xiaoying Li,
  7. Xiaoping Pi,
  8. Lipeng Wang,
  9. Li Zhan,
  10. Fajun Nan, and
  11. Zhaobing Gao
  1. State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
  1. Address correspondence to:
    Dr. Zhaobing Gao, Professor of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, People’s Republic of China. E-mail: zbgao{at}simm.ac.cn or Dr. Fajun Nan, Professor of Medicinal Chemistry, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo shou jing Road, Shanghai 201203, People’s Republic of China. E-mail: fjnan{at}simm.ac.cn
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Molecular Pharmacology: 87 (1)
Molecular Pharmacology
Vol. 87, Issue 1
1 Jan 2015
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Research ArticleArticle

Discovery of a Retigabine-Based KCNQ Channel Activator

Pingzheng Zhou, Yangming Zhang, Haiyan Xu, Fei Chen, Xueqin Chen, Xiaoying Li, Xiaoping Pi, Lipeng Wang, Li Zhan, Fajun Nan and Zhaobing Gao
Molecular Pharmacology January 1, 2015, 87 (1) 31-38; DOI: https://doi.org/10.1124/mol.114.095190

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Research ArticleArticle

Discovery of a Retigabine-Based KCNQ Channel Activator

Pingzheng Zhou, Yangming Zhang, Haiyan Xu, Fei Chen, Xueqin Chen, Xiaoying Li, Xiaoping Pi, Lipeng Wang, Li Zhan, Fajun Nan and Zhaobing Gao
Molecular Pharmacology January 1, 2015, 87 (1) 31-38; DOI: https://doi.org/10.1124/mol.114.095190
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