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P-Retigabine: An N-Propargyled Retigabine with Improved Brain Distribution and Enhanced Antiepileptic Activity
Pingzheng Zhou, Yangming Zhang, Haiyan Xu, Fei Chen, Xueqin Chen, Xiaoying Li, Xiaoping Pi, Lipeng Wang, Li Zhan, Fajun Nan and Zhaobing Gao
Molecular Pharmacology January 2015, 87 (1) 31-38; DOI: https://doi.org/10.1124/mol.114.095190
Pingzheng Zhou
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
Yangming Zhang
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
Haiyan Xu
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
Fei Chen
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
Xueqin Chen
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
Xiaoying Li
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
Xiaoping Pi
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
Lipeng Wang
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
Li Zhan
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
Fajun Nan
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China
Zhaobing Gao
State Key Laboratory of Drug Research (P.Z., H.X., X.C., X.P., L.W., L.Z., Z.G.), and National Center for Drug Screening (Y.Z., F.C., X.L., F.N.), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, People’s Republic of China

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Discovery of a Retigabine-Based KCNQ Channel Activator
Pingzheng Zhou, Yangming Zhang, Haiyan Xu, Fei Chen, Xueqin Chen, Xiaoying Li, Xiaoping Pi, Lipeng Wang, Li Zhan, Fajun Nan and Zhaobing Gao
Molecular Pharmacology January 1, 2015, 87 (1) 31-38; DOI: https://doi.org/10.1124/mol.114.095190
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Discovery of a Retigabine-Based KCNQ Channel Activator
Pingzheng Zhou, Yangming Zhang, Haiyan Xu, Fei Chen, Xueqin Chen, Xiaoying Li, Xiaoping Pi, Lipeng Wang, Li Zhan, Fajun Nan and Zhaobing Gao
Molecular Pharmacology January 1, 2015, 87 (1) 31-38; DOI: https://doi.org/10.1124/mol.114.095190
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