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Molecular Pharmacology

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Rapid CommunicationMinireview

The G Protein α Chaperone Ric-8 as a Potential Therapeutic Target

Makaía M. Papasergi, Bharti R. Patel and Gregory G. Tall
Molecular Pharmacology January 2015, 87 (1) 52-63; DOI: https://doi.org/10.1124/mol.114.094664
Makaía M. Papasergi
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York
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Bharti R. Patel
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York
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Gregory G. Tall
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York
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Article Information

vol. 87 no. 1 52-63
DOI 
https://doi.org/10.1124/mol.114.094664
PubMed 
25319541

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 10, 2014
  • Accepted October 14, 2014
  • Published online November 19, 2014.

Article Versions

  • Earlier version (October 15, 2014 - 08:13).
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Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Makaía M. Papasergi,
  2. Bharti R. Patel, and
  3. Gregory G. Tall
  1. Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York
  1. Address correspondence to:
    Dr. Gregory G. Tall, Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642. E-mail: gregory_tall{at}urmc.rochester.edu
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Molecular Pharmacology: 87 (1)
Molecular Pharmacology
Vol. 87, Issue 1
1 Jan 2015
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Rapid CommunicationMinireview

The G Protein α Chaperone Ric-8

Makaía M. Papasergi, Bharti R. Patel and Gregory G. Tall
Molecular Pharmacology January 1, 2015, 87 (1) 52-63; DOI: https://doi.org/10.1124/mol.114.094664

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Rapid CommunicationMinireview

The G Protein α Chaperone Ric-8

Makaía M. Papasergi, Bharti R. Patel and Gregory G. Tall
Molecular Pharmacology January 1, 2015, 87 (1) 52-63; DOI: https://doi.org/10.1124/mol.114.094664
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  • Article
    • Abstract
    • Introduction
    • Ric-8 Regulation of G Protein Abundance
    • Ric-8 as a G Protein α Subunit Guanine Nucleotide Exchange Factor
    • How Does Ric-8 Regulate Gαi/o Protein-Controlled Mitotic Spindle Positioning?
    • Should Ric-8 Be a Therapeutic Target for Diseases Driven by Mutant Gα Subunits or to Attenuate GPCR Signaling?
    • Therapeutic Chaperone Inhibition Is an Established Paradigm
    • Defining the Ric-8/Gα PPI and Targeting It for Inhibition
    • Summary
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

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