Table of Contents

Articles

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  Pharmacological Inhibition and Genetic Knockdown of Exchange Protein Directly Activated by cAMP 1 Reduce Pancreatic Cancer Metastasis In Vivo

  Muayad Almahariq, Celia Chao, Fang C. Mei, Mark R. Hellmich, Igor Patrikeev, Massoud Motamedi and Xiaodong Cheng

  Molecular Pharmacology February 2015, 87 (2) 142-149; DOI: https://doi.org/10.1124/mol.114.095158
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  Insulin-Like Growth Factor-1 Receptor Signaling Increases the Invasive Potential of Human Epidermal Growth Factor Receptor 2–Overexpressing Breast Cancer Cells via Src-Focal Adhesion Kinase and Forkhead Box Protein M1

  Eduardo Sanabria-Figueroa, Siobhan M. Donnelly, Kevin C. Foy, Meghan C. Buss, Robert C. Castellino, Elisavet Paplomata, Latonia Taliaferro-Smith, Pravin T.P. Kaumaya and Rita Nahta

  Molecular Pharmacology February 2015, 87 (2) 150-161; DOI: https://doi.org/10.1124/mol.114.095380
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  The Inverse Agonist DG172 Triggers a PPARβ/δ-Independent Myeloid Lineage Shift and Promotes GM-CSF/IL-4-Induced Dendritic Cell Differentiation

  Sonja Lieber, Frithjof Scheer, Florian Finkernagel, Wolfgang Meissner, Gavin Giehl, Cornelia Brendel, Wibke E. Diederich, Sabine Müller-Brüsselbach and Rolf Müller

  Molecular Pharmacology February 2015, 87 (2) 162-173; DOI: https://doi.org/10.1124/mol.114.094672
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  New Pyrimido-Indole Compound CD-160130 Preferentially Inhibits the K_V11.1B Isoform and Produces Antileukemic Effects without Cardiotoxicity

  Luca Gasparoli, Massimo D’Amico, Marika Masselli, Serena Pillozzi, Rachel Caves, Rawan Khuwaileh, Wolfgang Tiedke, Kenneth Mugridge, Alessandro Pratesi, John S. Mitcheson, Giuseppe Basso, Andrea Becchetti and Annarosa Arcangeli

  Molecular Pharmacology February 2015, 87 (2) 183-196; DOI: https://doi.org/10.1124/mol.114.094920
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  (4-(Bis(4-Fluorophenyl)Methyl)Piperazin-1-yl)(Cyclohexyl)Methanone Hydrochloride (LDK1229): A New Cannabinoid CB₁ Receptor Inverse Agonist from the Class of Benzhydryl Piperazine Analogs

  Mariam M. Mahmoud, Teresa Olszewska, Hui Liu, Derek M. Shore, Dow P. Hurst, Patricia H. Reggio, Dai Lu and Debra A. Kendall

  Molecular Pharmacology February 2015, 87 (2) 197-206; DOI: https://doi.org/10.1124/mol.114.095471
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  Reporting Sodium Channel Activity Using Calcium Flux: Pharmacological Promiscuity of Cardiac Nav1.5

  Hongkang Zhang, Beiyan Zou, Fang Du, Kaiping Xu and Min Li

  Molecular Pharmacology February 2015, 87 (2) 207-217; DOI: https://doi.org/10.1124/mol.114.094789
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  Phage Display–Mediated Discovery of Novel Tyrosinase-Targeting Tetrapeptide Inhibitors Reveals the Significance of N-Terminal Preference of Cysteine Residues and Their Functional Sulfur Atom

  Yu-Ching Lee, Nai-Wan Hsiao, Tien-Sheng Tseng, Wang-Chuan Chen, Hui-Hsiung Lin, Sy-Jye Leu, Ei-Wen Yang and Keng-Chang Tsai

  Molecular Pharmacology February 2015, 87 (2) 218-230; DOI: https://doi.org/10.1124/mol.114.094185
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  RETRACTION: STAT3 Regulates Steady-State Expression of Synaptopodin in Cultured Mouse Podocytes

  Mousa Abkhezr and Stuart E. Dryer

  Molecular Pharmacology February 2015, 87 (2) 231-239; DOI: https://doi.org/10.1124/mol.114.094508
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  Novel Mechanism of Voltage-Gated N-type (Ca_v2.2) Calcium Channel Inhibition Revealed through α-Conotoxin Vc1.1 Activation of the GABA_B Receptor

  Thuan G. Huynh, Hartmut Cuny, Paul A. Slesinger and David J. Adams

  Molecular Pharmacology February 2015, 87 (2) 240-250; DOI: https://doi.org/10.1124/mol.114.096156
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  Potent and Efficacious Inhibition of CXCR2 Signaling by Biparatopic Nanobodies Combining Two Distinct Modes of Action

  M. E. Bradley, B. Dombrecht, J. Manini, J. Willis, D. Vlerick, S. De Taeye, K. Van den Heede, A. Roobrouck, E. Grot, T. C. Kent, T. Laeremans, S. Steffensen, G. Van Heeke, Z. Brown, S. J. Charlton and K. D. Cromie

  Molecular Pharmacology February 2015, 87 (2) 251-262; DOI: https://doi.org/10.1124/mol.114.094821
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  A Peptide Mimicking a Region in Proliferating Cell Nuclear Antigen Specific to Key Protein Interactions Is Cytotoxic to Breast Cancer

  Shanna J. Smith, Long Gu, Elizabeth A. Phipps, Lacey E. Dobrolecki, Karla S. Mabrey, Pattie Gulley, Kelsey L. Dillehay, Zhongyun Dong, Gregg B. Fields, Yun-Ru Chen, David Ann, Robert J. Hickey and Linda H. Malkas

  Molecular Pharmacology February 2015, 87 (2) 263-276; DOI: https://doi.org/10.1124/mol.114.093211
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  Signaling Mechanism Underlying the Promotion of Keratinocyte Migration by Angiotensin II

  Hiroki Sakai, Kenji Matsuura, Yoshie Tanaka, Takeshi Honda, Teruo Nishida and Makoto Inui

  Molecular Pharmacology February 2015, 87 (2) 277-285; DOI: https://doi.org/10.1124/mol.114.096461
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  Reversing Translational Suppression and Induction of Toxicity in Pancreatic Cancer Cells Using a Chemoprevention Gene Therapy Approach

  Siddik Sarkar, Bridget A. Quinn, Xuening Shen, Paul Dent, Swadesh K. Das, Luni Emdad, Devanand Sarkar and Paul B. Fisher

  Molecular Pharmacology February 2015, 87 (2) 286-295; DOI: https://doi.org/10.1124/mol.114.094375
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  Antiproliferation Activity of a Small Molecule Repressor of Liver Receptor Homolog 1

  Cesar A. Corzo, Yelenis Mari, Mi Ra Chang, Tanya Khan, Dana Kuruvilla, Philippe Nuhant, Naresh Kumar, Graham M. West, Derek R. Duckett, William R. Roush and Patrick R. Griffin

  Molecular Pharmacology February 2015, 87 (2) 296-304; DOI: https://doi.org/10.1124/mol.114.095554
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  Sodium Ion Binding Pocket Mutations and Adenosine A_2A Receptor Function

  Arnault Massink, Hugo Gutiérrez-de-Terán, Eelke B. Lenselink, Natalia V. Ortiz Zacarías, Lizi Xia, Laura H. Heitman, Vsevolod Katritch, Raymond C. Stevens and Adriaan P. IJzerman

  Molecular Pharmacology February 2015, 87 (2) 305-313; DOI: https://doi.org/10.1124/mol.114.095737
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  Modulation of Peroxisome Proliferator-Activated Receptor-α Activity by Bile Acids Causes Circadian Changes in the Intestinal Expression of Octn1/Slc22a4 in Mice

  Erika Wada, Satoru Koyanagi, Naoki Kusunose, Takahiro Akamine, Hiroaki Masui, Hana Hashimoto, Naoya Matsunaga and Shigehiro Ohdo

  Molecular Pharmacology February 2015, 87 (2) 314-322; DOI: https://doi.org/10.1124/mol.114.094979
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  An Integrated Biological Approach to Guide the Development of Metal-Chelating Inhibitors of Influenza Virus PA Endonuclease

  Annelies Stevaert, Salvatore Nurra, Nicolino Pala, Mauro Carcelli, Dominga Rogolino, Caitlin Shepard, Robert A. Domaoal, Baek Kim, Mercedes Alfonso-Prieto, Salvatore A. E. Marras, Mario Sechi and Lieve Naesens

  Molecular Pharmacology February 2015, 87 (2) 323-337; DOI: https://doi.org/10.1124/mol.114.095588
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  A Novel Pan-Negative-Gating Modulator of K_Ca2/3 Channels, Fluoro-Di-Benzoate, RA-2, Inhibits Endothelium-Derived Hyperpolarization–Type Relaxation in Coronary Artery and Produces Bradycardia In Vivo

  Aida Oliván-Viguera, Marta Sofía Valero, Nicole Coleman, Brandon M. Brown, Celia Laría, María Divina Murillo, José A. Gálvez, María D. Díaz-de-Villegas, Heike Wulff, Ramón Badorrey and Ralf Köhler

  Molecular Pharmacology February 2015, 87 (2) 338-348; DOI: https://doi.org/10.1124/mol.114.095745
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  Engineered Hyperphosphorylation of the β₂-Adrenoceptor Prolongs Arrestin-3 Binding and Induces Arrestin Internalization

  Diana Zindel, Adrian J. Butcher, Suleiman Al-Sabah, Peter Lanzerstorfer, Julian Weghuber, Andrew B. Tobin, Moritz Bünemann and Cornelius Krasel

  Molecular Pharmacology February 2015, 87 (2) 349-362; DOI: https://doi.org/10.1124/mol.114.095422