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Molecular Pharmacology

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Table of Contents

February 01, 2015; Volume 87,Issue 2

Minireview

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    An Overview of Hedgehog Signaling in Fibrosis
    Liping Hu, Xiangyang Lin, Hong Lu, Bicheng Chen and Yongheng Bai
    Molecular Pharmacology February 2015, 87 (2) 174-182; DOI: https://doi.org/10.1124/mol.114.095141

Articles

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    Pharmacological Inhibition and Genetic Knockdown of Exchange Protein Directly Activated by cAMP 1 Reduce Pancreatic Cancer Metastasis In Vivo
    Muayad Almahariq, Celia Chao, Fang C. Mei, Mark R. Hellmich, Igor Patrikeev, Massoud Motamedi and Xiaodong Cheng
    Molecular Pharmacology February 2015, 87 (2) 142-149; DOI: https://doi.org/10.1124/mol.114.095158
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    Insulin-Like Growth Factor-1 Receptor Signaling Increases the Invasive Potential of Human Epidermal Growth Factor Receptor 2–Overexpressing Breast Cancer Cells via Src-Focal Adhesion Kinase and Forkhead Box Protein M1
    Eduardo Sanabria-Figueroa, Siobhan M. Donnelly, Kevin C. Foy, Meghan C. Buss, Robert C. Castellino, Elisavet Paplomata, Latonia Taliaferro-Smith, Pravin T.P. Kaumaya and Rita Nahta
    Molecular Pharmacology February 2015, 87 (2) 150-161; DOI: https://doi.org/10.1124/mol.114.095380
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    The Inverse Agonist DG172 Triggers a PPARβ/δ-Independent Myeloid Lineage Shift and Promotes GM-CSF/IL-4-Induced Dendritic Cell Differentiation
    Sonja Lieber, Frithjof Scheer, Florian Finkernagel, Wolfgang Meissner, Gavin Giehl, Cornelia Brendel, Wibke E. Diederich, Sabine Müller-Brüsselbach and Rolf Müller
    Molecular Pharmacology February 2015, 87 (2) 162-173; DOI: https://doi.org/10.1124/mol.114.094672
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    New Pyrimido-Indole Compound CD-160130 Preferentially Inhibits the KV11.1B Isoform and Produces Antileukemic Effects without Cardiotoxicity
    Luca Gasparoli, Massimo D’Amico, Marika Masselli, Serena Pillozzi, Rachel Caves, Rawan Khuwaileh, Wolfgang Tiedke, Kenneth Mugridge, Alessandro Pratesi, John S. Mitcheson, Giuseppe Basso, Andrea Becchetti and Annarosa Arcangeli
    Molecular Pharmacology February 2015, 87 (2) 183-196; DOI: https://doi.org/10.1124/mol.114.094920
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    (4-(Bis(4-Fluorophenyl)Methyl)Piperazin-1-yl)(Cyclohexyl)Methanone Hydrochloride (LDK1229): A New Cannabinoid CB1 Receptor Inverse Agonist from the Class of Benzhydryl Piperazine Analogs
    Mariam M. Mahmoud, Teresa Olszewska, Hui Liu, Derek M. Shore, Dow P. Hurst, Patricia H. Reggio, Dai Lu and Debra A. Kendall
    Molecular Pharmacology February 2015, 87 (2) 197-206; DOI: https://doi.org/10.1124/mol.114.095471
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    Reporting Sodium Channel Activity Using Calcium Flux: Pharmacological Promiscuity of Cardiac Nav1.5
    Hongkang Zhang, Beiyan Zou, Fang Du, Kaiping Xu and Min Li
    Molecular Pharmacology February 2015, 87 (2) 207-217; DOI: https://doi.org/10.1124/mol.114.094789
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    Phage Display–Mediated Discovery of Novel Tyrosinase-Targeting Tetrapeptide Inhibitors Reveals the Significance of N-Terminal Preference of Cysteine Residues and Their Functional Sulfur Atom
    Yu-Ching Lee, Nai-Wan Hsiao, Tien-Sheng Tseng, Wang-Chuan Chen, Hui-Hsiung Lin, Sy-Jye Leu, Ei-Wen Yang and Keng-Chang Tsai
    Molecular Pharmacology February 2015, 87 (2) 218-230; DOI: https://doi.org/10.1124/mol.114.094185
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    RETRACTION: STAT3 Regulates Steady-State Expression of Synaptopodin in Cultured Mouse Podocytes
    Mousa Abkhezr and Stuart E. Dryer
    Molecular Pharmacology February 2015, 87 (2) 231-239; DOI: https://doi.org/10.1124/mol.114.094508
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    Novel Mechanism of Voltage-Gated N-type (Cav2.2) Calcium Channel Inhibition Revealed through α-Conotoxin Vc1.1 Activation of the GABAB Receptor
    Thuan G. Huynh, Hartmut Cuny, Paul A. Slesinger and David J. Adams
    Molecular Pharmacology February 2015, 87 (2) 240-250; DOI: https://doi.org/10.1124/mol.114.096156
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    Potent and Efficacious Inhibition of CXCR2 Signaling by Biparatopic Nanobodies Combining Two Distinct Modes of Action
    M. E. Bradley, B. Dombrecht, J. Manini, J. Willis, D. Vlerick, S. De Taeye, K. Van den Heede, A. Roobrouck, E. Grot, T. C. Kent, T. Laeremans, S. Steffensen, G. Van Heeke, Z. Brown, S. J. Charlton and K. D. Cromie
    Molecular Pharmacology February 2015, 87 (2) 251-262; DOI: https://doi.org/10.1124/mol.114.094821
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    A Peptide Mimicking a Region in Proliferating Cell Nuclear Antigen Specific to Key Protein Interactions Is Cytotoxic to Breast Cancer
    Shanna J. Smith, Long Gu, Elizabeth A. Phipps, Lacey E. Dobrolecki, Karla S. Mabrey, Pattie Gulley, Kelsey L. Dillehay, Zhongyun Dong, Gregg B. Fields, Yun-Ru Chen, David Ann, Robert J. Hickey and Linda H. Malkas
    Molecular Pharmacology February 2015, 87 (2) 263-276; DOI: https://doi.org/10.1124/mol.114.093211
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    Signaling Mechanism Underlying the Promotion of Keratinocyte Migration by Angiotensin II
    Hiroki Sakai, Kenji Matsuura, Yoshie Tanaka, Takeshi Honda, Teruo Nishida and Makoto Inui
    Molecular Pharmacology February 2015, 87 (2) 277-285; DOI: https://doi.org/10.1124/mol.114.096461
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    Reversing Translational Suppression and Induction of Toxicity in Pancreatic Cancer Cells Using a Chemoprevention Gene Therapy Approach
    Siddik Sarkar, Bridget A. Quinn, Xuening Shen, Paul Dent, Swadesh K. Das, Luni Emdad, Devanand Sarkar and Paul B. Fisher
    Molecular Pharmacology February 2015, 87 (2) 286-295; DOI: https://doi.org/10.1124/mol.114.094375
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    Antiproliferation Activity of a Small Molecule Repressor of Liver Receptor Homolog 1
    Cesar A. Corzo, Yelenis Mari, Mi Ra Chang, Tanya Khan, Dana Kuruvilla, Philippe Nuhant, Naresh Kumar, Graham M. West, Derek R. Duckett, William R. Roush and Patrick R. Griffin
    Molecular Pharmacology February 2015, 87 (2) 296-304; DOI: https://doi.org/10.1124/mol.114.095554
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    Sodium Ion Binding Pocket Mutations and Adenosine A2A Receptor Function
    Arnault Massink, Hugo Gutiérrez-de-Terán, Eelke B. Lenselink, Natalia V. Ortiz Zacarías, Lizi Xia, Laura H. Heitman, Vsevolod Katritch, Raymond C. Stevens and Adriaan P. IJzerman
    Molecular Pharmacology February 2015, 87 (2) 305-313; DOI: https://doi.org/10.1124/mol.114.095737
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    Modulation of Peroxisome Proliferator-Activated Receptor-α Activity by Bile Acids Causes Circadian Changes in the Intestinal Expression of Octn1/Slc22a4 in Mice
    Erika Wada, Satoru Koyanagi, Naoki Kusunose, Takahiro Akamine, Hiroaki Masui, Hana Hashimoto, Naoya Matsunaga and Shigehiro Ohdo
    Molecular Pharmacology February 2015, 87 (2) 314-322; DOI: https://doi.org/10.1124/mol.114.094979
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    An Integrated Biological Approach to Guide the Development of Metal-Chelating Inhibitors of Influenza Virus PA Endonuclease
    Annelies Stevaert, Salvatore Nurra, Nicolino Pala, Mauro Carcelli, Dominga Rogolino, Caitlin Shepard, Robert A. Domaoal, Baek Kim, Mercedes Alfonso-Prieto, Salvatore A. E. Marras, Mario Sechi and Lieve Naesens
    Molecular Pharmacology February 2015, 87 (2) 323-337; DOI: https://doi.org/10.1124/mol.114.095588
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    A Novel Pan-Negative-Gating Modulator of KCa2/3 Channels, Fluoro-Di-Benzoate, RA-2, Inhibits Endothelium-Derived Hyperpolarization–Type Relaxation in Coronary Artery and Produces Bradycardia In Vivo
    Aida Oliván-Viguera, Marta Sofía Valero, Nicole Coleman, Brandon M. Brown, Celia Laría, María Divina Murillo, José A. Gálvez, María D. Díaz-de-Villegas, Heike Wulff, Ramón Badorrey and Ralf Köhler
    Molecular Pharmacology February 2015, 87 (2) 338-348; DOI: https://doi.org/10.1124/mol.114.095745
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    Engineered Hyperphosphorylation of the β2-Adrenoceptor Prolongs Arrestin-3 Binding and Induces Arrestin Internalization
    Diana Zindel, Adrian J. Butcher, Suleiman Al-Sabah, Peter Lanzerstorfer, Julian Weghuber, Andrew B. Tobin, Moritz Bünemann and Cornelius Krasel
    Molecular Pharmacology February 2015, 87 (2) 349-362; DOI: https://doi.org/10.1124/mol.114.095422
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In this issue

Molecular Pharmacology: 87 (2)
Molecular Pharmacology
Vol. 87, Issue 2
1 Feb 2015
  • Table of Contents
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  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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