Table of Contents

Articles

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  Structural Domains Underlying the Activation of Acid-Sensing Ion Channel 2a

  Laura-Nadine Schuhmacher, Shyam Srivats and Ewan St. John Smith

  Molecular Pharmacology April 2015, 87 (4) 561-571; DOI: https://doi.org/10.1124/mol.114.096909
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  Dehydrocrenatidine Is a Novel Janus Kinase Inhibitor

  Jing Zhang, Ning Zhu, Yuping Du, Qifeng Bai, Xing Chen, Jing Nan, Xiaodong Qin, Xinxin Zhang, Jianwen Hou, Qin Wang and Jinbo Yang

  Molecular Pharmacology April 2015, 87 (4) 572-581; DOI: https://doi.org/10.1124/mol.114.095208
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  Repression of the Nuclear Receptor Small Heterodimer Partner by Steatotic Drugs and in Advanced Nonalcoholic Fatty Liver Disease

  Marta Benet, Carla Guzmán, Sandra Pisonero-Vaquero, M. Victoria García-Mediavilla, Sonia Sánchez-Campos, M. Luz Martínez-Chantar, M. Teresa Donato, José Vicente Castell and Ramiro Jover

  Molecular Pharmacology April 2015, 87 (4) 582-594; DOI: https://doi.org/10.1124/mol.114.096313
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  Rapid Throughput Analysis Demonstrates that Chemicals with Distinct Seizurogenic Mechanisms Differentially Alter Ca²⁺ Dynamics in Networks Formed by Hippocampal Neurons in Culture

  Zhengyu Cao, Xiaohan Zou, Yanjun Cui, Susan Hulsizer, Pamela J. Lein, Heike Wulff and Isaac N. Pessah

  Molecular Pharmacology April 2015, 87 (4) 595-605; DOI: https://doi.org/10.1124/mol.114.096701
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  Identification and Characterization of a Selective Allosteric Antagonist of Human P2X4 Receptor Channels

  Ariel R. Ase, Nicolette S. Honson, Helmi Zaghdane, Tom A. Pfeifer and Philippe Séguéla

  Molecular Pharmacology April 2015, 87 (4) 606-616; DOI: https://doi.org/10.1124/mol.114.096222
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  Transient Receptor Potential Melastatin-3 (TRPM3)–Induced Activation of AP-1 Requires Ca²⁺ Ions and the Transcription Factors c-Jun, ATF2, and Ternary Complex Factor

  Andrea Lesch, Xin Hui, Peter Lipp and Gerald Thiel

  Molecular Pharmacology April 2015, 87 (4) 617-628; DOI: https://doi.org/10.1124/mol.114.095695
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  Pharmacological Characterization of [³H]VUF11211, a Novel Radiolabeled Small-Molecule Inverse Agonist for the Chemokine Receptor CXCR3

  Danny J. Scholten, Maikel Wijtmans, Jeffrey R. van Senten, Hans Custers, Ailas Stunnenberg, Iwan J. P. de Esch, Martine J. Smit and Rob Leurs

  Molecular Pharmacology April 2015, 87 (4) 639-648; DOI: https://doi.org/10.1124/mol.114.095265
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  Structural and Biophysical Characterization of Human Cytochromes P450 2B6 and 2A6 Bound to Volatile Hydrocarbons: Analysis and Comparison

  Manish B. Shah, P. Ross Wilderman, Jingbao Liu, Hyun-Hee Jang, Qinghai Zhang, C. David Stout and James R. Halpert

  Molecular Pharmacology April 2015, 87 (4) 649-659; DOI: https://doi.org/10.1124/mol.114.097014
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  Native Serotonin 5-HT_2C Receptors Are Expressed as Homodimers on the Apical Surface of Choroid Plexus Epithelial Cells

  Katharine Herrick-Davis, Ellinor Grinde, Tara Lindsley, Milt Teitler, Filippo Mancia, Ann Cowan and Joseph E. Mazurkiewicz

  Molecular Pharmacology April 2015, 87 (4) 660-673; DOI: https://doi.org/10.1124/mol.114.096636
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  SLC13A5 Is a Novel Transcriptional Target of the Pregnane X Receptor and Sensitizes Drug-Induced Steatosis in Human Liver

  Linhao Li, Haishan Li, Brandy Garzel, Hui Yang, Tatsuya Sueyoshi, Qing Li, Yan Shu, Junran Zhang, Bingfang Hu, Scott Heyward, Timothy Moeller, Wen Xie, Masahiko Negishi and Hongbing Wang

  Molecular Pharmacology April 2015, 87 (4) 674-682; DOI: https://doi.org/10.1124/mol.114.097287
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  Mis-Trafficking of Endosomal Urokinase Proteins Triggers Drug-Induced Glioma Nonapoptotic Cell Death

  Nagarekha Pasupuleti, Ana Cristina Grodzki and Fredric Gorin

  Molecular Pharmacology April 2015, 87 (4) 683-696; DOI: https://doi.org/10.1124/mol.114.096602
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  A Renal-Like Organic Anion Transport System in the Ciliary Epithelium of the Bovine and Human Eye

  Jonghwa Lee, Mohammad Shahidullah, Adam Hotchkiss, Miguel Coca-Prados, Nicholas A. Delamere and Ryan M. Pelis

  Molecular Pharmacology April 2015, 87 (4) 697-705; DOI: https://doi.org/10.1124/mol.114.096578
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  Delineation of a Conserved Arrestin-Biased Signaling Repertoire In Vivo

  Stuart Maudsley, Bronwen Martin, Diane Gesty-Palmer, Huey Cheung, Calvin Johnson, Shamit Patel, Kevin G. Becker, William H. Wood, Yongqing Zhang, Elin Lehrmann and Louis M. Luttrell

  Molecular Pharmacology April 2015, 87 (4) 706-717; DOI: https://doi.org/10.1124/mol.114.095224
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  A G Protein–Coupled Receptor Dimer Imaging Assay Reveals Selectively Modified Pharmacology of Neuropeptide Y Y1/Y5 Receptor Heterodimers

  Laura E. Kilpatrick, Laura J. Humphrys and Nicholas D. Holliday

  Molecular Pharmacology April 2015, 87 (4) 718-732; DOI: https://doi.org/10.1124/mol.114.095356
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  Cytochrome b₅ Is a Major Determinant of Human Cytochrome P450 CYP2D6 and CYP3A4 Activity In Vivo

  Colin J. Henderson, Lesley A. McLaughlin, Nico Scheer, Lesley A. Stanley and C. Roland Wolf

  Molecular Pharmacology April 2015, 87 (4) 733-739; DOI: https://doi.org/10.1124/mol.114.097394
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  Detection of New Biased Agonists for the Serotonin 5-HT_2A Receptor: Modeling and Experimental Validation

  Maria Martí-Solano, Alba Iglesias, Gianni de Fabritiis, Ferran Sanz, José Brea, M. Isabel Loza, Manuel Pastor and Jana Selent

  Molecular Pharmacology April 2015, 87 (4) 740-746; DOI: https://doi.org/10.1124/mol.114.097022
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  Cannabinoid Receptor–Interacting Protein 1a Modulates CB₁ Receptor Signaling and Regulation

  Tricia H. Smith, Lawrence C. Blume, Alex Straiker, Jordan O. Cox, Bethany G. David, Julie R. Secor McVoy, Katherine W. Sayers, Justin L. Poklis, Rehab A. Abdullah, Michaela Egertová, Ching-Kang Chen, Ken Mackie, Maurice R. Elphick, Allyn C. Howlett and Dana E. Selley

  Molecular Pharmacology April 2015, 87 (4) 747-765; DOI: https://doi.org/10.1124/mol.114.096495