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Research ArticleArticle

Cannabinoid Receptor–Interacting Protein 1a Modulates CB1 Receptor Signaling and Regulation

Tricia H. Smith, Lawrence C. Blume, Alex Straiker, Jordan O. Cox, Bethany G. David, Julie R. Secor McVoy, Katherine W. Sayers, Justin L. Poklis, Rehab A. Abdullah, Michaela Egertová, Ching-Kang Chen, Ken Mackie, Maurice R. Elphick, Allyn C. Howlett and Dana E. Selley
Molecular Pharmacology April 2015, 87 (4) 747-765; DOI: https://doi.org/10.1124/mol.114.096495
Tricia H. Smith
Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies (T.H.S., J.O.C., B.G.D., J.R.S.M., J.L.P., R.A.A., D.E.S.), Department of Anatomy and Neurobiology (K.W.S.), Department of Biochemistry and Molecular Biology (C.-K.C.), Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina (L.C.B., A.C.H.); The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana (A.S., K.M.); and School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom (M.E., M.R.E.)
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Lawrence C. Blume
Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies (T.H.S., J.O.C., B.G.D., J.R.S.M., J.L.P., R.A.A., D.E.S.), Department of Anatomy and Neurobiology (K.W.S.), Department of Biochemistry and Molecular Biology (C.-K.C.), Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina (L.C.B., A.C.H.); The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana (A.S., K.M.); and School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom (M.E., M.R.E.)
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Alex Straiker
Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies (T.H.S., J.O.C., B.G.D., J.R.S.M., J.L.P., R.A.A., D.E.S.), Department of Anatomy and Neurobiology (K.W.S.), Department of Biochemistry and Molecular Biology (C.-K.C.), Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina (L.C.B., A.C.H.); The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana (A.S., K.M.); and School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom (M.E., M.R.E.)
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Jordan O. Cox
Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies (T.H.S., J.O.C., B.G.D., J.R.S.M., J.L.P., R.A.A., D.E.S.), Department of Anatomy and Neurobiology (K.W.S.), Department of Biochemistry and Molecular Biology (C.-K.C.), Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina (L.C.B., A.C.H.); The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana (A.S., K.M.); and School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom (M.E., M.R.E.)
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Bethany G. David
Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies (T.H.S., J.O.C., B.G.D., J.R.S.M., J.L.P., R.A.A., D.E.S.), Department of Anatomy and Neurobiology (K.W.S.), Department of Biochemistry and Molecular Biology (C.-K.C.), Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina (L.C.B., A.C.H.); The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana (A.S., K.M.); and School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom (M.E., M.R.E.)
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Julie R. Secor McVoy
Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies (T.H.S., J.O.C., B.G.D., J.R.S.M., J.L.P., R.A.A., D.E.S.), Department of Anatomy and Neurobiology (K.W.S.), Department of Biochemistry and Molecular Biology (C.-K.C.), Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina (L.C.B., A.C.H.); The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana (A.S., K.M.); and School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom (M.E., M.R.E.)
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Katherine W. Sayers
Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies (T.H.S., J.O.C., B.G.D., J.R.S.M., J.L.P., R.A.A., D.E.S.), Department of Anatomy and Neurobiology (K.W.S.), Department of Biochemistry and Molecular Biology (C.-K.C.), Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina (L.C.B., A.C.H.); The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana (A.S., K.M.); and School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom (M.E., M.R.E.)
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Justin L. Poklis
Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies (T.H.S., J.O.C., B.G.D., J.R.S.M., J.L.P., R.A.A., D.E.S.), Department of Anatomy and Neurobiology (K.W.S.), Department of Biochemistry and Molecular Biology (C.-K.C.), Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina (L.C.B., A.C.H.); The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana (A.S., K.M.); and School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom (M.E., M.R.E.)
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Rehab A. Abdullah
Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies (T.H.S., J.O.C., B.G.D., J.R.S.M., J.L.P., R.A.A., D.E.S.), Department of Anatomy and Neurobiology (K.W.S.), Department of Biochemistry and Molecular Biology (C.-K.C.), Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina (L.C.B., A.C.H.); The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana (A.S., K.M.); and School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom (M.E., M.R.E.)
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Michaela Egertová
Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies (T.H.S., J.O.C., B.G.D., J.R.S.M., J.L.P., R.A.A., D.E.S.), Department of Anatomy and Neurobiology (K.W.S.), Department of Biochemistry and Molecular Biology (C.-K.C.), Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina (L.C.B., A.C.H.); The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana (A.S., K.M.); and School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom (M.E., M.R.E.)
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Ching-Kang Chen
Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies (T.H.S., J.O.C., B.G.D., J.R.S.M., J.L.P., R.A.A., D.E.S.), Department of Anatomy and Neurobiology (K.W.S.), Department of Biochemistry and Molecular Biology (C.-K.C.), Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina (L.C.B., A.C.H.); The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana (A.S., K.M.); and School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom (M.E., M.R.E.)
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Ken Mackie
Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies (T.H.S., J.O.C., B.G.D., J.R.S.M., J.L.P., R.A.A., D.E.S.), Department of Anatomy and Neurobiology (K.W.S.), Department of Biochemistry and Molecular Biology (C.-K.C.), Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina (L.C.B., A.C.H.); The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana (A.S., K.M.); and School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom (M.E., M.R.E.)
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Maurice R. Elphick
Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies (T.H.S., J.O.C., B.G.D., J.R.S.M., J.L.P., R.A.A., D.E.S.), Department of Anatomy and Neurobiology (K.W.S.), Department of Biochemistry and Molecular Biology (C.-K.C.), Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina (L.C.B., A.C.H.); The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana (A.S., K.M.); and School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom (M.E., M.R.E.)
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Allyn C. Howlett
Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies (T.H.S., J.O.C., B.G.D., J.R.S.M., J.L.P., R.A.A., D.E.S.), Department of Anatomy and Neurobiology (K.W.S.), Department of Biochemistry and Molecular Biology (C.-K.C.), Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina (L.C.B., A.C.H.); The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana (A.S., K.M.); and School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom (M.E., M.R.E.)
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Dana E. Selley
Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies (T.H.S., J.O.C., B.G.D., J.R.S.M., J.L.P., R.A.A., D.E.S.), Department of Anatomy and Neurobiology (K.W.S.), Department of Biochemistry and Molecular Biology (C.-K.C.), Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina (L.C.B., A.C.H.); The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana (A.S., K.M.); and School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom (M.E., M.R.E.)
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Article Information

vol. 87 no. 4 747-765
DOI 
https://doi.org/10.1124/mol.114.096495
PubMed 
25657338

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received October 21, 2014
  • Accepted January 26, 2015
  • Published online March 6, 2015.

Article Versions

  • Earlier version (February 5, 2015 - 07:23).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Tricia H. Smith,
  2. Lawrence C. Blume,
  3. Alex Straiker,
  4. Jordan O. Cox,
  5. Bethany G. David,
  6. Julie R. Secor McVoy,
  7. Katherine W. Sayers,
  8. Justin L. Poklis,
  9. Rehab A. Abdullah,
  10. Michaela Egertová,
  11. Ching-Kang Chen,
  12. Ken Mackie,
  13. Maurice R. Elphick,
  14. Allyn C. Howlett, and
  15. Dana E. Selley
  1. Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies (T.H.S., J.O.C., B.G.D., J.R.S.M., J.L.P., R.A.A., D.E.S.), Department of Anatomy and Neurobiology (K.W.S.), Department of Biochemistry and Molecular Biology (C.-K.C.), Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina (L.C.B., A.C.H.); The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana (A.S., K.M.); and School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom (M.E., M.R.E.)
  1. Address correspondence to:
    Dr. Dana E. Selley, Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980524, McGuire Hall, 1112 East Clay Street, Richmond, VA 23298-0524. E-mail: deselley{at}vcu.edu
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Molecular Pharmacology: 87 (4)
Molecular Pharmacology
Vol. 87, Issue 4
1 Apr 2015
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Research ArticleArticle

CRIP1a Modulates CB1 Receptor Signaling and Regulation

Tricia H. Smith, Lawrence C. Blume, Alex Straiker, Jordan O. Cox, Bethany G. David, Julie R. Secor McVoy, Katherine W. Sayers, Justin L. Poklis, Rehab A. Abdullah, Michaela Egertová, Ching-Kang Chen, Ken Mackie, Maurice R. Elphick, Allyn C. Howlett and Dana E. Selley
Molecular Pharmacology April 1, 2015, 87 (4) 747-765; DOI: https://doi.org/10.1124/mol.114.096495

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Research ArticleArticle

CRIP1a Modulates CB1 Receptor Signaling and Regulation

Tricia H. Smith, Lawrence C. Blume, Alex Straiker, Jordan O. Cox, Bethany G. David, Julie R. Secor McVoy, Katherine W. Sayers, Justin L. Poklis, Rehab A. Abdullah, Michaela Egertová, Ching-Kang Chen, Ken Mackie, Maurice R. Elphick, Allyn C. Howlett and Dana E. Selley
Molecular Pharmacology April 1, 2015, 87 (4) 747-765; DOI: https://doi.org/10.1124/mol.114.096495
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