Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Molecular Pharmacology
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Molecular Pharmacology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit molpharm on Facebook
  • Follow molpharm on Twitter
  • Follow molpharm on LinkedIn
Research ArticleArticle

Yet Another Function of p53—The Switch That Determines Whether Radiation-Induced Autophagy Will Be Cytoprotective or Nonprotective: Implications for Autophagy Inhibition as a Therapeutic Strategy

Shweta Chakradeo, Khushboo Sharma, Aisha Alhaddad, Duaa Bakhshwin, Ngoc Le, Hisashi Harada, Wataru Nakajima, W. Andrew Yeudall, Suzy V. Torti, Frank M. Torti and David A. Gewirtz
Molecular Pharmacology May 2015, 87 (5) 803-814; DOI: https://doi.org/10.1124/mol.114.095273
Shweta Chakradeo
Departments of Medicine and Pharmacology and Toxicology, Massey Cancer Center (S.C., K.S., A.A., D.B., N.L., D.A.G.), and Department of Oral and Craniofacial Molecular Biology, School of Dentistry (H.H., W.N., W.A.Y.), Virginia Commonwealth University, Richmond, Virginia; and Departments of Molecular Biology and Biophysics (S.V.T.) and Medicine (F.M.T.), University of Connecticut Health Sciences, Farmington, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Khushboo Sharma
Departments of Medicine and Pharmacology and Toxicology, Massey Cancer Center (S.C., K.S., A.A., D.B., N.L., D.A.G.), and Department of Oral and Craniofacial Molecular Biology, School of Dentistry (H.H., W.N., W.A.Y.), Virginia Commonwealth University, Richmond, Virginia; and Departments of Molecular Biology and Biophysics (S.V.T.) and Medicine (F.M.T.), University of Connecticut Health Sciences, Farmington, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aisha Alhaddad
Departments of Medicine and Pharmacology and Toxicology, Massey Cancer Center (S.C., K.S., A.A., D.B., N.L., D.A.G.), and Department of Oral and Craniofacial Molecular Biology, School of Dentistry (H.H., W.N., W.A.Y.), Virginia Commonwealth University, Richmond, Virginia; and Departments of Molecular Biology and Biophysics (S.V.T.) and Medicine (F.M.T.), University of Connecticut Health Sciences, Farmington, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Duaa Bakhshwin
Departments of Medicine and Pharmacology and Toxicology, Massey Cancer Center (S.C., K.S., A.A., D.B., N.L., D.A.G.), and Department of Oral and Craniofacial Molecular Biology, School of Dentistry (H.H., W.N., W.A.Y.), Virginia Commonwealth University, Richmond, Virginia; and Departments of Molecular Biology and Biophysics (S.V.T.) and Medicine (F.M.T.), University of Connecticut Health Sciences, Farmington, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ngoc Le
Departments of Medicine and Pharmacology and Toxicology, Massey Cancer Center (S.C., K.S., A.A., D.B., N.L., D.A.G.), and Department of Oral and Craniofacial Molecular Biology, School of Dentistry (H.H., W.N., W.A.Y.), Virginia Commonwealth University, Richmond, Virginia; and Departments of Molecular Biology and Biophysics (S.V.T.) and Medicine (F.M.T.), University of Connecticut Health Sciences, Farmington, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hisashi Harada
Departments of Medicine and Pharmacology and Toxicology, Massey Cancer Center (S.C., K.S., A.A., D.B., N.L., D.A.G.), and Department of Oral and Craniofacial Molecular Biology, School of Dentistry (H.H., W.N., W.A.Y.), Virginia Commonwealth University, Richmond, Virginia; and Departments of Molecular Biology and Biophysics (S.V.T.) and Medicine (F.M.T.), University of Connecticut Health Sciences, Farmington, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wataru Nakajima
Departments of Medicine and Pharmacology and Toxicology, Massey Cancer Center (S.C., K.S., A.A., D.B., N.L., D.A.G.), and Department of Oral and Craniofacial Molecular Biology, School of Dentistry (H.H., W.N., W.A.Y.), Virginia Commonwealth University, Richmond, Virginia; and Departments of Molecular Biology and Biophysics (S.V.T.) and Medicine (F.M.T.), University of Connecticut Health Sciences, Farmington, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
W. Andrew Yeudall
Departments of Medicine and Pharmacology and Toxicology, Massey Cancer Center (S.C., K.S., A.A., D.B., N.L., D.A.G.), and Department of Oral and Craniofacial Molecular Biology, School of Dentistry (H.H., W.N., W.A.Y.), Virginia Commonwealth University, Richmond, Virginia; and Departments of Molecular Biology and Biophysics (S.V.T.) and Medicine (F.M.T.), University of Connecticut Health Sciences, Farmington, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Suzy V. Torti
Departments of Medicine and Pharmacology and Toxicology, Massey Cancer Center (S.C., K.S., A.A., D.B., N.L., D.A.G.), and Department of Oral and Craniofacial Molecular Biology, School of Dentistry (H.H., W.N., W.A.Y.), Virginia Commonwealth University, Richmond, Virginia; and Departments of Molecular Biology and Biophysics (S.V.T.) and Medicine (F.M.T.), University of Connecticut Health Sciences, Farmington, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Frank M. Torti
Departments of Medicine and Pharmacology and Toxicology, Massey Cancer Center (S.C., K.S., A.A., D.B., N.L., D.A.G.), and Department of Oral and Craniofacial Molecular Biology, School of Dentistry (H.H., W.N., W.A.Y.), Virginia Commonwealth University, Richmond, Virginia; and Departments of Molecular Biology and Biophysics (S.V.T.) and Medicine (F.M.T.), University of Connecticut Health Sciences, Farmington, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David A. Gewirtz
Departments of Medicine and Pharmacology and Toxicology, Massey Cancer Center (S.C., K.S., A.A., D.B., N.L., D.A.G.), and Department of Oral and Craniofacial Molecular Biology, School of Dentistry (H.H., W.N., W.A.Y.), Virginia Commonwealth University, Richmond, Virginia; and Departments of Molecular Biology and Biophysics (S.V.T.) and Medicine (F.M.T.), University of Connecticut Health Sciences, Farmington, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF
Loading

Article Information

vol. 87 no. 5 803-814
DOI 
https://doi.org/10.1124/mol.114.095273
PubMed 
25667224

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received August 6, 2014
  • Accepted February 9, 2015
  • Published online March 23, 2015.

Article Versions

  • Earlier version (February 9, 2015 - 10:12).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Shweta Chakradeo,
  2. Khushboo Sharma,
  3. Aisha Alhaddad,
  4. Duaa Bakhshwin,
  5. Ngoc Le,
  6. Hisashi Harada,
  7. Wataru Nakajima,
  8. W. Andrew Yeudall,
  9. Suzy V. Torti,
  10. Frank M. Torti, and
  11. David A. Gewirtz
  1. Departments of Medicine and Pharmacology and Toxicology, Massey Cancer Center (S.C., K.S., A.A., D.B., N.L., D.A.G.), and Department of Oral and Craniofacial Molecular Biology, School of Dentistry (H.H., W.N., W.A.Y.), Virginia Commonwealth University, Richmond, Virginia; and Departments of Molecular Biology and Biophysics (S.V.T.) and Medicine (F.M.T.), University of Connecticut Health Sciences, Farmington, Connecticut
  1. Address correspondence to:
    Dr. David A. Gewirtz, Massey Cancer Center, Virginia Commonwealth University, 401 College St., Richmond, VA 23298. E-mail: gewirtz{at}vcu.edu
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: February 2015 to March 2023

AbstractFullPdf
Feb 20152420219
Mar 2015272698
Apr 20154001646
May 20151261317
Jun 2015821415
Jul 2015532116
Aug 2015451426
Sep 20154287
Oct 2015481128
Nov 2015281414
Dec 20151012
Jan 2016251721
Feb 2016391212
Mar 2016291017
Apr 2016161212
May 20161279
Jun 201626610
Jul 201623820
Aug 2016311014
Sep 201619116
Oct 2016111310
Nov 201641610
Dec 201623518
Jan 201702517
Feb 201702723
Mar 201722510
Apr 20173146
May 201741912
Jun 201752313
Jul 201712122
Aug 2017121013
Sep 20176912
Oct 201791515
Nov 201772319
Dec 2017171810
Jan 201814228
Feb 2018161418
Mar 20189259
Apr 2018153315
May 201891812
Jun 201862410
Jul 201842325
Aug 201862111
Sep 201871510
Oct 201851714
Nov 201822810
Dec 20180810
Jan 20192129
Feb 20195158
Mar 20192163
Apr 201911528
May 20193179
Jun 201941415
Jul 201912110
Aug 201953414
Sep 201902023
Oct 201922020
Nov 20192156
Dec 20194128
Jan 20200137
Feb 202011210
Mar 20201115
Apr 20200814
May 2020287
Jun 2020069
Jul 20201112
Aug 2020595
Sep 202051114
Oct 202022511
Nov 20202118
Dec 202081411
Jan 202151515
Feb 202181013
Mar 202112159
Apr 20213114
May 20213522
Jun 20211920
Jul 20211445
Aug 20211611
Sep 20211215
Oct 20212432
Nov 20212430
Dec 20211310
Jan 20221851
Feb 20221512
Mar 20224228
Apr 20223901
May 20223210
Jun 20221111
Jul 20221703
Aug 20221521
Sep 2022614
Oct 20221610
Nov 20221210
Dec 2022810
Jan 20234312
Feb 20232222
Mar 20231723

PreviousNext
Back to top

In this issue

Molecular Pharmacology: 87 (5)
Molecular Pharmacology
Vol. 87, Issue 5
1 May 2015
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Molecular Pharmacology article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Yet Another Function of p53—The Switch That Determines Whether Radiation-Induced Autophagy Will Be Cytoprotective or Nonprotective: Implications for Autophagy Inhibition as a Therapeutic Strategy
(Your Name) has forwarded a page to you from Molecular Pharmacology
(Your Name) thought you would be interested in this article in Molecular Pharmacology.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

p53, Autophagy, and Radiation in Cancer Therapy

Shweta Chakradeo, Khushboo Sharma, Aisha Alhaddad, Duaa Bakhshwin, Ngoc Le, Hisashi Harada, Wataru Nakajima, W. Andrew Yeudall, Suzy V. Torti, Frank M. Torti and David A. Gewirtz
Molecular Pharmacology May 1, 2015, 87 (5) 803-814; DOI: https://doi.org/10.1124/mol.114.095273

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

p53, Autophagy, and Radiation in Cancer Therapy

Shweta Chakradeo, Khushboo Sharma, Aisha Alhaddad, Duaa Bakhshwin, Ngoc Le, Hisashi Harada, Wataru Nakajima, W. Andrew Yeudall, Suzy V. Torti, Frank M. Torti and David A. Gewirtz
Molecular Pharmacology May 1, 2015, 87 (5) 803-814; DOI: https://doi.org/10.1124/mol.114.095273
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Mechanism of the selective action of paraherquamide A
  • Use-Dependent Relief of A-887826 Inhibition
  • Benzbromarone Relaxes Airway Smooth Muscle via BK Activation
Show more Articles

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About Molecular Pharmacology
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Journal of Pharmacology and Experimental Therapeutics
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0111 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics