Research ArticleArticle
Synthetic Metallochaperone ZMC1 Rescues Mutant p53 Conformation by Transporting Zinc into Cells as an Ionophore
Adam R. Blanden, Xin Yu, Aaron J. Wolfe, John A. Gilleran, David J. Augeri, Ryan S. O’Dell, Eric C. Olson, S. David Kimball, Thomas J. Emge, Liviu Movileanu, Darren R. Carpizo and Stewart N. Loh
Molecular Pharmacology May 2015, 87 (5) 825-831; DOI: https://doi.org/10.1124/mol.114.097550
Adam R. Blanden
Department of Biochemistry and Molecular Biology (A.R.B.,S.N.L.) and Department of Neuroscience and Physiology (R.S.O., E.C.O.), State University of New York Upstate Medical University, Syracuse, New York; Rutgers Cancer Institute of New Jersey (X.Y., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., D.R.C.), Office of Translational Sciences (J.A.G., D.J.A., S.D.K.), and Department of Chemistry and Chemical Biology (T.J.E.), Rutgers University, New Brunswick, New Jersey; and Department of Physics, Syracuse University, Syracuse, New York (A.J.W., L.M.)
Xin Yu
Department of Biochemistry and Molecular Biology (A.R.B.,S.N.L.) and Department of Neuroscience and Physiology (R.S.O., E.C.O.), State University of New York Upstate Medical University, Syracuse, New York; Rutgers Cancer Institute of New Jersey (X.Y., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., D.R.C.), Office of Translational Sciences (J.A.G., D.J.A., S.D.K.), and Department of Chemistry and Chemical Biology (T.J.E.), Rutgers University, New Brunswick, New Jersey; and Department of Physics, Syracuse University, Syracuse, New York (A.J.W., L.M.)
Aaron J. Wolfe
Department of Biochemistry and Molecular Biology (A.R.B.,S.N.L.) and Department of Neuroscience and Physiology (R.S.O., E.C.O.), State University of New York Upstate Medical University, Syracuse, New York; Rutgers Cancer Institute of New Jersey (X.Y., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., D.R.C.), Office of Translational Sciences (J.A.G., D.J.A., S.D.K.), and Department of Chemistry and Chemical Biology (T.J.E.), Rutgers University, New Brunswick, New Jersey; and Department of Physics, Syracuse University, Syracuse, New York (A.J.W., L.M.)
John A. Gilleran
Department of Biochemistry and Molecular Biology (A.R.B.,S.N.L.) and Department of Neuroscience and Physiology (R.S.O., E.C.O.), State University of New York Upstate Medical University, Syracuse, New York; Rutgers Cancer Institute of New Jersey (X.Y., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., D.R.C.), Office of Translational Sciences (J.A.G., D.J.A., S.D.K.), and Department of Chemistry and Chemical Biology (T.J.E.), Rutgers University, New Brunswick, New Jersey; and Department of Physics, Syracuse University, Syracuse, New York (A.J.W., L.M.)
David J. Augeri
Department of Biochemistry and Molecular Biology (A.R.B.,S.N.L.) and Department of Neuroscience and Physiology (R.S.O., E.C.O.), State University of New York Upstate Medical University, Syracuse, New York; Rutgers Cancer Institute of New Jersey (X.Y., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., D.R.C.), Office of Translational Sciences (J.A.G., D.J.A., S.D.K.), and Department of Chemistry and Chemical Biology (T.J.E.), Rutgers University, New Brunswick, New Jersey; and Department of Physics, Syracuse University, Syracuse, New York (A.J.W., L.M.)
Ryan S. O’Dell
Department of Biochemistry and Molecular Biology (A.R.B.,S.N.L.) and Department of Neuroscience and Physiology (R.S.O., E.C.O.), State University of New York Upstate Medical University, Syracuse, New York; Rutgers Cancer Institute of New Jersey (X.Y., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., D.R.C.), Office of Translational Sciences (J.A.G., D.J.A., S.D.K.), and Department of Chemistry and Chemical Biology (T.J.E.), Rutgers University, New Brunswick, New Jersey; and Department of Physics, Syracuse University, Syracuse, New York (A.J.W., L.M.)
Eric C. Olson
Department of Biochemistry and Molecular Biology (A.R.B.,S.N.L.) and Department of Neuroscience and Physiology (R.S.O., E.C.O.), State University of New York Upstate Medical University, Syracuse, New York; Rutgers Cancer Institute of New Jersey (X.Y., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., D.R.C.), Office of Translational Sciences (J.A.G., D.J.A., S.D.K.), and Department of Chemistry and Chemical Biology (T.J.E.), Rutgers University, New Brunswick, New Jersey; and Department of Physics, Syracuse University, Syracuse, New York (A.J.W., L.M.)
S. David Kimball
Department of Biochemistry and Molecular Biology (A.R.B.,S.N.L.) and Department of Neuroscience and Physiology (R.S.O., E.C.O.), State University of New York Upstate Medical University, Syracuse, New York; Rutgers Cancer Institute of New Jersey (X.Y., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., D.R.C.), Office of Translational Sciences (J.A.G., D.J.A., S.D.K.), and Department of Chemistry and Chemical Biology (T.J.E.), Rutgers University, New Brunswick, New Jersey; and Department of Physics, Syracuse University, Syracuse, New York (A.J.W., L.M.)
Thomas J. Emge
Department of Biochemistry and Molecular Biology (A.R.B.,S.N.L.) and Department of Neuroscience and Physiology (R.S.O., E.C.O.), State University of New York Upstate Medical University, Syracuse, New York; Rutgers Cancer Institute of New Jersey (X.Y., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., D.R.C.), Office of Translational Sciences (J.A.G., D.J.A., S.D.K.), and Department of Chemistry and Chemical Biology (T.J.E.), Rutgers University, New Brunswick, New Jersey; and Department of Physics, Syracuse University, Syracuse, New York (A.J.W., L.M.)
Liviu Movileanu
Department of Biochemistry and Molecular Biology (A.R.B.,S.N.L.) and Department of Neuroscience and Physiology (R.S.O., E.C.O.), State University of New York Upstate Medical University, Syracuse, New York; Rutgers Cancer Institute of New Jersey (X.Y., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., D.R.C.), Office of Translational Sciences (J.A.G., D.J.A., S.D.K.), and Department of Chemistry and Chemical Biology (T.J.E.), Rutgers University, New Brunswick, New Jersey; and Department of Physics, Syracuse University, Syracuse, New York (A.J.W., L.M.)
Darren R. Carpizo
Department of Biochemistry and Molecular Biology (A.R.B.,S.N.L.) and Department of Neuroscience and Physiology (R.S.O., E.C.O.), State University of New York Upstate Medical University, Syracuse, New York; Rutgers Cancer Institute of New Jersey (X.Y., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., D.R.C.), Office of Translational Sciences (J.A.G., D.J.A., S.D.K.), and Department of Chemistry and Chemical Biology (T.J.E.), Rutgers University, New Brunswick, New Jersey; and Department of Physics, Syracuse University, Syracuse, New York (A.J.W., L.M.)
Stewart N. Loh
Department of Biochemistry and Molecular Biology (A.R.B.,S.N.L.) and Department of Neuroscience and Physiology (R.S.O., E.C.O.), State University of New York Upstate Medical University, Syracuse, New York; Rutgers Cancer Institute of New Jersey (X.Y., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., D.R.C.), Office of Translational Sciences (J.A.G., D.J.A., S.D.K.), and Department of Chemistry and Chemical Biology (T.J.E.), Rutgers University, New Brunswick, New Jersey; and Department of Physics, Syracuse University, Syracuse, New York (A.J.W., L.M.)
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Research ArticleArticle
ZMC1 Reactivates Mutant p53 by Transporting Zn2+
Adam R. Blanden, Xin Yu, Aaron J. Wolfe, John A. Gilleran, David J. Augeri, Ryan S. O’Dell, Eric C. Olson, S. David Kimball, Thomas J. Emge, Liviu Movileanu, Darren R. Carpizo and Stewart N. Loh
Molecular Pharmacology May 1, 2015, 87 (5) 825-831; DOI: https://doi.org/10.1124/mol.114.097550
Research ArticleArticle
ZMC1 Reactivates Mutant p53 by Transporting Zn2+
Adam R. Blanden, Xin Yu, Aaron J. Wolfe, John A. Gilleran, David J. Augeri, Ryan S. O’Dell, Eric C. Olson, S. David Kimball, Thomas J. Emge, Liviu Movileanu, Darren R. Carpizo and Stewart N. Loh
Molecular Pharmacology May 1, 2015, 87 (5) 825-831; DOI: https://doi.org/10.1124/mol.114.097550
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