Table of Contents

Articles

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  Molecular Determinants of CGS21680 Binding to the Human Adenosine A_2A Receptor

  Guillaume Lebon, Patricia C. Edwards, Andrew G. W. Leslie and Christopher G. Tate

  Molecular Pharmacology June 2015, 87 (6) 907-915; DOI: https://doi.org/10.1124/mol.114.097360
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  FTY720 Phosphate Activates Sphingosine-1-Phosphate Receptor 2 and Selectively Couples to Gα_12/13/Rho/ROCK to Induce Myofibroblast Contraction

  Katrin Sobel, Lucile Monnier, Katalin Menyhart, Matthias Bolinger, Rolf Studer, Oliver Nayler and John Gatfield

  Molecular Pharmacology June 2015, 87 (6) 916-927; DOI: https://doi.org/10.1124/mol.114.097261
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  Cyclic Adenosine 3′,5′-Monophosphate Elevation and Biological Signaling through a Secretin Family G_s-Coupled G Protein–Coupled Receptor Are Restricted to a Single Adenylate Cyclase Isoform

  Andrew C. Emery, Xiu-Huai Liu, Wenqin Xu, Maribeth V. Eiden and Lee E. Eiden

  Molecular Pharmacology June 2015, 87 (6) 928-935; DOI: https://doi.org/10.1124/mol.115.098087
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  The Molecular Basis of Oligomeric Organization of the Human M₃ Muscarinic Acetylcholine Receptor

  María José Varela Liste, Gianluigi Caltabiano, Richard J. Ward, Elisa Alvarez-Curto, Sara Marsango and Graeme Milligan

  Molecular Pharmacology June 2015, 87 (6) 936-953; DOI: https://doi.org/10.1124/mol.114.096925
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  Salmeterol Efficacy and Bias in the Activation and Kinase-Mediated Desensitization of β2-Adrenergic Receptors

  Luis E. Gimenez, Faiza Baameur, Sharat J. Vayttaden and Richard B. Clark

  Molecular Pharmacology June 2015, 87 (6) 954-964; DOI: https://doi.org/10.1124/mol.114.096800
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  Pharmacological NAD-Boosting Strategies Improve Mitochondrial Homeostasis in Human Complex I–Mutant Fibroblasts

  Roberta Felici, Andrea Lapucci, Leonardo Cavone, Sara Pratesi, Rolando Berlinguer-Palmini and Alberto Chiarugi

  Molecular Pharmacology June 2015, 87 (6) 965-971; DOI: https://doi.org/10.1124/mol.114.097204
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  Investigation of the Fate of Type I Angiotensin Receptor after Biased Activation

  Gyöngyi Szakadáti, András D. Tóth, Ilona Oláh, László Sándor Erdélyi, Tamas Balla, Péter Várnai, László Hunyady and András Balla

  Molecular Pharmacology June 2015, 87 (6) 972-981; DOI: https://doi.org/10.1124/mol.114.097030
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  Characterization of Angiotensin II Molecular Determinants Involved in AT₁ Receptor Functional Selectivity

  Ivana Domazet, Brian J. Holleran, Alexandra Richard, Camille Vandenberghe, Pierre Lavigne, Emanuel Escher, Richard Leduc and Gaétan Guillemette

  Molecular Pharmacology June 2015, 87 (6) 982-995; DOI: https://doi.org/10.1124/mol.114.097337
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  The Novel Ribonucleotide Reductase Inhibitor COH29 Inhibits DNA Repair In Vitro

  Mei-Chuan Chen, Bingsen Zhou, Keqiang Zhang, Yate-Ching Yuan, Frank Un, Shuya Hu, Chih-Ming Chou, Chun-Han Chen, Jun Wu, Yan Wang, Xiyong Liu, D. Lynne Smith, Hongzhi Li, Zheng Liu, Charles D. Warden, Leila Su, Linda H. Malkas, Young Min Chung, Mickey C.-T. Hu and Yun Yen

  Molecular Pharmacology June 2015, 87 (6) 996-1005; DOI: https://doi.org/10.1124/mol.114.094987
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  Dual Targeting of the Androgen Receptor and Hypoxia-Inducible Factor 1α Pathways Synergistically Inhibits Castration-Resistant Prostate Cancer Cells

  Elena V. Fernandez, Kelie M. Reece, Ariel M. Ley, Sarah M. Troutman, Tristan M. Sissung, Douglas K. Price, Cindy H. Chau and William D. Figg

  Molecular Pharmacology June 2015, 87 (6) 1006-1012; DOI: https://doi.org/10.1124/mol.114.097477
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  Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells

  Maria Thomas, Christine Bayha, Silvia Vetter, Ute Hofmann, Michael Schwarz, Ulrich M. Zanger and Albert Braeuning

  Molecular Pharmacology June 2015, 87 (6) 1013-1020; DOI: https://doi.org/10.1124/mol.114.097402
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  The Nurr1 Activator 1,1-Bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB

  Briana R. De Miranda, Katriana A. Popichak, Sean L. Hammond, Bryce A. Jorgensen, Aaron T. Phillips, Stephen Safe and Ronald B. Tjalkens

  Molecular Pharmacology June 2015, 87 (6) 1021-1034; DOI: https://doi.org/10.1124/mol.114.095398
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  Brainstem Brain-Derived Neurotrophic Factor Signaling Is Required for Histone Deacetylase Inhibitor–Induced Pain Relief

  Wenjuan Tao, Quan Chen, Lu Wang, Wenjie Zhou, Yunping Wang and Zhi Zhang

  Molecular Pharmacology June 2015, 87 (6) 1035-1041; DOI: https://doi.org/10.1124/mol.115.098186
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  The Link between Inactivation and High-Affinity Block of hERG1 Channels

  Wei Wu, Alison Gardner and Michael C. Sanguinetti

  Molecular Pharmacology June 2015, 87 (6) 1042-1050; DOI: https://doi.org/10.1124/mol.115.098111