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Molecular Pharmacology

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Research ArticleArticle

The Nurr1 Activator 1,1-Bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB

Briana R. De Miranda, Katriana A. Popichak, Sean L. Hammond, Bryce A. Jorgensen, Aaron T. Phillips, Stephen Safe and Ronald B. Tjalkens
Molecular Pharmacology June 2015, 87 (6) 1021-1034; DOI: https://doi.org/10.1124/mol.114.095398
Briana R. De Miranda
Center for Environmental Medicine, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado (B.R.D.M., K.A.P., S.L.H., B.A.J., A.T.P., R.B.T.); Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas; and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (S.S.)
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Katriana A. Popichak
Center for Environmental Medicine, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado (B.R.D.M., K.A.P., S.L.H., B.A.J., A.T.P., R.B.T.); Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas; and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (S.S.)
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Sean L. Hammond
Center for Environmental Medicine, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado (B.R.D.M., K.A.P., S.L.H., B.A.J., A.T.P., R.B.T.); Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas; and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (S.S.)
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Bryce A. Jorgensen
Center for Environmental Medicine, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado (B.R.D.M., K.A.P., S.L.H., B.A.J., A.T.P., R.B.T.); Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas; and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (S.S.)
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Aaron T. Phillips
Center for Environmental Medicine, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado (B.R.D.M., K.A.P., S.L.H., B.A.J., A.T.P., R.B.T.); Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas; and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (S.S.)
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Stephen Safe
Center for Environmental Medicine, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado (B.R.D.M., K.A.P., S.L.H., B.A.J., A.T.P., R.B.T.); Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas; and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (S.S.)
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Ronald B. Tjalkens
Center for Environmental Medicine, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado (B.R.D.M., K.A.P., S.L.H., B.A.J., A.T.P., R.B.T.); Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas; and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (S.S.)
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Article Information

vol. 87 no. 6 1021-1034
DOI 
https://doi.org/10.1124/mol.114.095398
PubMed 
25858541

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received August 12, 2014
  • Accepted April 6, 2015
  • Published online May 7, 2015.

Article Versions

  • Earlier version (April 9, 2015 - 07:40).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Briana R. De Miranda,
  2. Katriana A. Popichak,
  3. Sean L. Hammond,
  4. Bryce A. Jorgensen,
  5. Aaron T. Phillips,
  6. Stephen Safe, and
  7. Ronald B. Tjalkens
  1. Center for Environmental Medicine, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado (B.R.D.M., K.A.P., S.L.H., B.A.J., A.T.P., R.B.T.); Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas; and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (S.S.)
  1. Address correspondence to:
    Dr. Ronald B. Tjalkens, Professor of Toxicology and Neuroscience, Associate Director, Center for Environmental Medicine, Department of Environmental and Radiological Health Sciences, Colorado State University, 1680 Campus Delivery, Fort Collins, CO 80523-1680. E-mail: ron.tjalkens{at}colostate.edu
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Molecular Pharmacology: 87 (6)
Molecular Pharmacology
Vol. 87, Issue 6
1 Jun 2015
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Research ArticleArticle

Novel Diindolylmethane Analogs Inhibit NF-κB in Microglia

Briana R. De Miranda, Katriana A. Popichak, Sean L. Hammond, Bryce A. Jorgensen, Aaron T. Phillips, Stephen Safe and Ronald B. Tjalkens
Molecular Pharmacology June 1, 2015, 87 (6) 1021-1034; DOI: https://doi.org/10.1124/mol.114.095398

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Research ArticleArticle

Novel Diindolylmethane Analogs Inhibit NF-κB in Microglia

Briana R. De Miranda, Katriana A. Popichak, Sean L. Hammond, Bryce A. Jorgensen, Aaron T. Phillips, Stephen Safe and Ronald B. Tjalkens
Molecular Pharmacology June 1, 2015, 87 (6) 1021-1034; DOI: https://doi.org/10.1124/mol.114.095398
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