Table of Contents

Articles

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  AT-1001 Is a Partial Agonist with High Affinity and Selectivity at Human and Rat α3β4 Nicotinic Cholinergic Receptors

  Edward W. Tuan, Andrew G. Horti, Thao T. Olson, Yongiun Gao, Craig A. Stockmeier, Nour Al-Muhtasib, Carrie Bowman Dalley, Amanda E. Lewin, Barry B. Wolfe, Niaz Sahibzada, Yingxian Xiao and Kenneth J. Kellar

  Molecular Pharmacology October 2015, 88 (4) 640-649; DOI: https://doi.org/10.1124/mol.115.099978
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  Bidirectional Effect of Pregnenolone Sulfate on GluN1/GluN2A N-Methyl-d-Aspartate Receptor Gating Depending on Extracellular Calcium and Intracellular Milieu

  Divyan A. Chopra, Daniel T. Monaghan and Shashank M. Dravid

  Molecular Pharmacology October 2015, 88 (4) 650-659; DOI: https://doi.org/10.1124/mol.115.100396
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  Intracellular Dynamics and Fate of a Humanized Anti–Interleukin-6 Receptor Monoclonal Antibody, Tocilizumab

  Keiko Fujimoto, Hiroaki Ida, Yuko Hirota, Masaki Ishigai, Jun Amano and Yoshitaka Tanaka

  Molecular Pharmacology October 2015, 88 (4) 660-675; DOI: https://doi.org/10.1124/mol.115.099184
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  Substrate and Inhibitor–Specific Conformational Changes in the Human Serotonin Transporter Revealed by Voltage-Clamp Fluorometry

  Pella C. Söderhielm, Jacob Andersen, Lachlan Munro, Anne T. Nielsen and Anders S. Kristensen

  Molecular Pharmacology October 2015, 88 (4) 676-688; DOI: https://doi.org/10.1124/mol.115.099911
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  Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP

  Yonjung Kim, Marc O. Anderson, Jinhong Park, Min Goo Lee, Wan Namkung and A. S. Verkman

  Molecular Pharmacology October 2015, 88 (4) 689-696; DOI: https://doi.org/10.1124/mol.115.098368
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  Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity

  Azadeh Shahsavar, Philip K. Ahring, Jeppe A. Olsen, Christian Krintel, Jette S. Kastrup, Thomas Balle and Michael Gajhede

  Molecular Pharmacology October 2015, 88 (4) 697-707; DOI: https://doi.org/10.1124/mol.115.098061
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  Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells

  Yu Ri Jung, Eun Ju Kim, Hyeong Jwa Choi, Jung-Jin Park, Hak-Su Kim, Yoon-Jin Lee, Myung-Jin Park and Minyoung Lee

  Molecular Pharmacology October 2015, 88 (4) 708-719; DOI: https://doi.org/10.1124/mol.115.098616
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  Suppression of Cytosolic NADPH Pool by Thionicotinamide Increases Oxidative Stress and Synergizes with Chemotherapy

  Philip M. Tedeschi, HongXia Lin, Murugesan Gounder, John E. Kerrigan, Emine Ercikan Abali, Kathleen Scotto and Joseph R. Bertino

  Molecular Pharmacology October 2015, 88 (4) 720-727; DOI: https://doi.org/10.1124/mol.114.096727
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  Protein Kinase C (PKC)ζ Pseudosubstrate Inhibitor Peptide Promiscuously Binds PKC Family Isoforms and Disrupts Conventional PKC Targeting and Translocation

  Amy S. Bogard and Steven J. Tavalin

  Molecular Pharmacology October 2015, 88 (4) 728-735; DOI: https://doi.org/10.1124/mol.115.099457
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  Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABA_A Receptors

  Megan M. Eaton, Lily Q. Cao, Ziwei Chen, Nicholas P. Franks, Alex S. Evers and Gustav Akk

  Molecular Pharmacology October 2015, 88 (4) 736-745; DOI: https://doi.org/10.1124/mol.115.100347
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  Pregnane X Receptor Represses HNF4α Gene to Induce Insulin-Like Growth Factor–Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells

  Susumu Kodama, Yuichi Yamazaki and Masahiko Negishi

  Molecular Pharmacology October 2015, 88 (4) 746-757; DOI: https://doi.org/10.1124/mol.115.099341
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  Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform-Specific Use of Multiple Interaction Sites

  Cameron S. Brand, Rachna Sadana, Sundeep Malik, Alan V. Smrcka and Carmen W. Dessauer

  Molecular Pharmacology October 2015, 88 (4) 758-767; DOI: https://doi.org/10.1124/mol.115.099556
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  Preclinical Evaluation of DMA, a Bisbenzimidazole, as Radioprotector: Toxicity, Pharmacokinetics, and Biodistribution Studies in Balb/c Mice

  Hemlata Nimesh, Vinod Tiwari, Chunhua Yang, Sushma R. Gundala, Krishna Chuttani, Puja P. Hazari, Anil K. Mishra, Abhisheak Sharma, Jawahar Lal, Anju Katyal, Ritu Aneja and Vibha Tandon

  Molecular Pharmacology October 2015, 88 (4) 768-778; DOI: https://doi.org/10.1124/mol.115.098376
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  Label-Free Kinetics: Exploiting Functional Hemi-Equilibrium to Derive Rate Constants for Muscarinic Receptor Antagonists

  Darren M. Riddy, Celine Valant, Patricia Rueda, William N. Charman, Patrick M. Sexton, Roger J. Summers, Arthur Christopoulos and Christopher J. Langmead

  Molecular Pharmacology October 2015, 88 (4) 779-790; DOI: https://doi.org/10.1124/mol.115.100545
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  Potentiators of Defective ΔF508–CFTR Gating that Do Not Interfere with Corrector Action

  Puay-Wah Phuan, Guido Veit, Joseph A. Tan, Walter E. Finkbeiner, Gergely L. Lukacs and A. S. Verkman

  Molecular Pharmacology October 2015, 88 (4) 791-799; DOI: https://doi.org/10.1124/mol.115.099689
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  Suppression of Cytochrome P450 3A4 Function by UDP-Glucuronosyltransferase 2B7 through a Protein-Protein Interaction: Cooperative Roles of the Cytosolic Carboxyl-Terminal Domain and the Luminal Anchoring Region

  Yuu Miyauchi, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie, Hideyuki Yamada and Yuji Ishii

  Molecular Pharmacology October 2015, 88 (4) 800-812; DOI: https://doi.org/10.1124/mol.115.098582