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Molecular Pharmacology

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Research ArticleArticle

Intracellular Dynamics and Fate of a Humanized Anti–Interleukin-6 Receptor Monoclonal Antibody, Tocilizumab

Keiko Fujimoto, Hiroaki Ida, Yuko Hirota, Masaki Ishigai, Jun Amano and Yoshitaka Tanaka
Molecular Pharmacology October 2015, 88 (4) 660-675; DOI: https://doi.org/10.1124/mol.115.099184
Keiko Fujimoto
Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences (K.F., H.I., Y.H., Y.T.), and Organelle Homeostasis Research Center (K.F., Y.T.), Kyushu University, Maidashi, Fukuoka, Japan; and Chugai Pharmaceutical Co., Ltd., Fuji-Gotemba Research Laboratories, Komakado, Gotemba-shi, Shizuoka, Japan (M.I., J.A.)
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Hiroaki Ida
Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences (K.F., H.I., Y.H., Y.T.), and Organelle Homeostasis Research Center (K.F., Y.T.), Kyushu University, Maidashi, Fukuoka, Japan; and Chugai Pharmaceutical Co., Ltd., Fuji-Gotemba Research Laboratories, Komakado, Gotemba-shi, Shizuoka, Japan (M.I., J.A.)
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Yuko Hirota
Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences (K.F., H.I., Y.H., Y.T.), and Organelle Homeostasis Research Center (K.F., Y.T.), Kyushu University, Maidashi, Fukuoka, Japan; and Chugai Pharmaceutical Co., Ltd., Fuji-Gotemba Research Laboratories, Komakado, Gotemba-shi, Shizuoka, Japan (M.I., J.A.)
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Masaki Ishigai
Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences (K.F., H.I., Y.H., Y.T.), and Organelle Homeostasis Research Center (K.F., Y.T.), Kyushu University, Maidashi, Fukuoka, Japan; and Chugai Pharmaceutical Co., Ltd., Fuji-Gotemba Research Laboratories, Komakado, Gotemba-shi, Shizuoka, Japan (M.I., J.A.)
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Jun Amano
Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences (K.F., H.I., Y.H., Y.T.), and Organelle Homeostasis Research Center (K.F., Y.T.), Kyushu University, Maidashi, Fukuoka, Japan; and Chugai Pharmaceutical Co., Ltd., Fuji-Gotemba Research Laboratories, Komakado, Gotemba-shi, Shizuoka, Japan (M.I., J.A.)
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Yoshitaka Tanaka
Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences (K.F., H.I., Y.H., Y.T.), and Organelle Homeostasis Research Center (K.F., Y.T.), Kyushu University, Maidashi, Fukuoka, Japan; and Chugai Pharmaceutical Co., Ltd., Fuji-Gotemba Research Laboratories, Komakado, Gotemba-shi, Shizuoka, Japan (M.I., J.A.)
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Article Information

vol. 88 no. 4 660-675
DOI 
https://doi.org/10.1124/mol.115.099184
PubMed 
26180046

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received March 26, 2015
  • Accepted July 13, 2015
  • Published online August 21, 2015.

Article Versions

  • Earlier version (July 15, 2015 - 06:15).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Keiko Fujimoto,
  2. Hiroaki Ida,
  3. Yuko Hirota,
  4. Masaki Ishigai,
  5. Jun Amano, and
  6. Yoshitaka Tanaka
  1. Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences (K.F., H.I., Y.H., Y.T.), and Organelle Homeostasis Research Center (K.F., Y.T.), Kyushu University, Maidashi, Fukuoka, Japan; and Chugai Pharmaceutical Co., Ltd., Fuji-Gotemba Research Laboratories, Komakado, Gotemba-shi, Shizuoka, Japan (M.I., J.A.)
  1. Address correspondence to:
    Yoshitaka Tanaka, Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka 812-8582 Japan. E-mail: ytanaka{at}phar.kyushu-u.ac.jp or Jun Amano, Chugai Pharmaceutical Co., Ltd., Fuji-Gotemba Research Laboratories, 1-135 Komakado, Gotemba-shi, Shizuoka 412-8513, Japan. E-mail: amanojn{at}chugai-pharm.co.jp
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Molecular Pharmacology: 88 (4)
Molecular Pharmacology
Vol. 88, Issue 4
1 Oct 2015
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Research ArticleArticle

Intracellular Dynamics of Tocilizumab by IL-6R and FcRn

Keiko Fujimoto, Hiroaki Ida, Yuko Hirota, Masaki Ishigai, Jun Amano and Yoshitaka Tanaka
Molecular Pharmacology October 1, 2015, 88 (4) 660-675; DOI: https://doi.org/10.1124/mol.115.099184

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Research ArticleArticle

Intracellular Dynamics of Tocilizumab by IL-6R and FcRn

Keiko Fujimoto, Hiroaki Ida, Yuko Hirota, Masaki Ishigai, Jun Amano and Yoshitaka Tanaka
Molecular Pharmacology October 1, 2015, 88 (4) 660-675; DOI: https://doi.org/10.1124/mol.115.099184
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