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Molecular Pharmacology

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Research ArticleArticle

Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP

Yonjung Kim, Marc O. Anderson, Jinhong Park, Min Goo Lee, Wan Namkung and A. S. Verkman
Molecular Pharmacology October 2015, 88 (4) 689-696; DOI: https://doi.org/10.1124/mol.115.098368
Yonjung Kim
Department of Pharmacology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea (Y.K., M.G.L.); Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California (M.O.A.); College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea (J.P., W.N.); and Departments of Medicine and Physiology, University of California, San Francisco, California (A.S.V.)
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Marc O. Anderson
Department of Pharmacology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea (Y.K., M.G.L.); Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California (M.O.A.); College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea (J.P., W.N.); and Departments of Medicine and Physiology, University of California, San Francisco, California (A.S.V.)
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Jinhong Park
Department of Pharmacology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea (Y.K., M.G.L.); Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California (M.O.A.); College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea (J.P., W.N.); and Departments of Medicine and Physiology, University of California, San Francisco, California (A.S.V.)
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Min Goo Lee
Department of Pharmacology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea (Y.K., M.G.L.); Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California (M.O.A.); College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea (J.P., W.N.); and Departments of Medicine and Physiology, University of California, San Francisco, California (A.S.V.)
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Wan Namkung
Department of Pharmacology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea (Y.K., M.G.L.); Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California (M.O.A.); College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea (J.P., W.N.); and Departments of Medicine and Physiology, University of California, San Francisco, California (A.S.V.)
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A. S. Verkman
Department of Pharmacology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea (Y.K., M.G.L.); Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California (M.O.A.); College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea (J.P., W.N.); and Departments of Medicine and Physiology, University of California, San Francisco, California (A.S.V.)
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Article Information

vol. 88 no. 4 689-696
DOI 
https://doi.org/10.1124/mol.115.098368
PubMed 
26174774

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received February 10, 2015
  • Accepted July 13, 2015
  • Published online August 21, 2015.

Article Versions

  • Earlier version (July 14, 2015 - 06:27).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yonjung Kim,
  2. Marc O. Anderson,
  3. Jinhong Park,
  4. Min Goo Lee,
  5. Wan Namkung, and
  6. A. S. Verkman
  1. Department of Pharmacology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea (Y.K., M.G.L.); Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California (M.O.A.); College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea (J.P., W.N.); and Departments of Medicine and Physiology, University of California, San Francisco, California (A.S.V.)
  1. Address correspondence to:
    Alan S. Verkman, 1246 Health Sciences East Tower, University of California, San Francisco, CA 94143-0521. E-mail: Alan.Verkman{at}ucsf.edu
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Molecular Pharmacology: 88 (4)
Molecular Pharmacology
Vol. 88, Issue 4
1 Oct 2015
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Research ArticleArticle

CFTR Inhibition by (R)-BPO-27

Yonjung Kim, Marc O. Anderson, Jinhong Park, Min Goo Lee, Wan Namkung and A. S. Verkman
Molecular Pharmacology October 1, 2015, 88 (4) 689-696; DOI: https://doi.org/10.1124/mol.115.098368

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Research ArticleArticle

CFTR Inhibition by (R)-BPO-27

Yonjung Kim, Marc O. Anderson, Jinhong Park, Min Goo Lee, Wan Namkung and A. S. Verkman
Molecular Pharmacology October 1, 2015, 88 (4) 689-696; DOI: https://doi.org/10.1124/mol.115.098368
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