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Molecular Pharmacology

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Research ArticleArticle

Suppression of Cytochrome P450 3A4 Function by UDP-Glucuronosyltransferase 2B7 through a Protein-Protein Interaction: Cooperative Roles of the Cytosolic Carboxyl-Terminal Domain and the Luminal Anchoring Region

Yuu Miyauchi, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie, Hideyuki Yamada and Yuji Ishii
Molecular Pharmacology October 2015, 88 (4) 800-812; DOI: https://doi.org/10.1124/mol.115.098582
Yuu Miyauchi
Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (Y.M., H.Y., Y.I.); Tohoku Pharmaceutical University, Sendai, Japan (K.N.); Food Safety Commission, Cabinet Office, Government of Japan, Tokyo, Japan (Y.Y.); and Department of Clinical Pharmacology, Flinders Medical Center and Flinders University, Adelaide, Australia (P.I.M.)
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Kiyoshi Nagata
Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (Y.M., H.Y., Y.I.); Tohoku Pharmaceutical University, Sendai, Japan (K.N.); Food Safety Commission, Cabinet Office, Government of Japan, Tokyo, Japan (Y.Y.); and Department of Clinical Pharmacology, Flinders Medical Center and Flinders University, Adelaide, Australia (P.I.M.)
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Yasushi Yamazoe
Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (Y.M., H.Y., Y.I.); Tohoku Pharmaceutical University, Sendai, Japan (K.N.); Food Safety Commission, Cabinet Office, Government of Japan, Tokyo, Japan (Y.Y.); and Department of Clinical Pharmacology, Flinders Medical Center and Flinders University, Adelaide, Australia (P.I.M.)
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Peter I. Mackenzie
Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (Y.M., H.Y., Y.I.); Tohoku Pharmaceutical University, Sendai, Japan (K.N.); Food Safety Commission, Cabinet Office, Government of Japan, Tokyo, Japan (Y.Y.); and Department of Clinical Pharmacology, Flinders Medical Center and Flinders University, Adelaide, Australia (P.I.M.)
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Hideyuki Yamada
Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (Y.M., H.Y., Y.I.); Tohoku Pharmaceutical University, Sendai, Japan (K.N.); Food Safety Commission, Cabinet Office, Government of Japan, Tokyo, Japan (Y.Y.); and Department of Clinical Pharmacology, Flinders Medical Center and Flinders University, Adelaide, Australia (P.I.M.)
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Yuji Ishii
Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (Y.M., H.Y., Y.I.); Tohoku Pharmaceutical University, Sendai, Japan (K.N.); Food Safety Commission, Cabinet Office, Government of Japan, Tokyo, Japan (Y.Y.); and Department of Clinical Pharmacology, Flinders Medical Center and Flinders University, Adelaide, Australia (P.I.M.)
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Article Information

vol. 88 no. 4 800-812
DOI 
https://doi.org/10.1124/mol.115.098582
PubMed 
26243732

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received February 23, 2015
  • Accepted July 31, 2015
  • Published online September 2, 2015.

Article Versions

  • Earlier version (August 4, 2015 - 08:45).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yuu Miyauchi,
  2. Kiyoshi Nagata,
  3. Yasushi Yamazoe,
  4. Peter I. Mackenzie,
  5. Hideyuki Yamada, and
  6. Yuji Ishii
  1. Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (Y.M., H.Y., Y.I.); Tohoku Pharmaceutical University, Sendai, Japan (K.N.); Food Safety Commission, Cabinet Office, Government of Japan, Tokyo, Japan (Y.Y.); and Department of Clinical Pharmacology, Flinders Medical Center and Flinders University, Adelaide, Australia (P.I.M.)
  1. Address correspondence to:
    Yuji Ishii, Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. E-mail: ishii{at}phar.kyushu-u.ac.jp
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Molecular Pharmacology: 88 (4)
Molecular Pharmacology
Vol. 88, Issue 4
1 Oct 2015
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Research ArticleArticle

UGT2B7 Suppresses CYP3A4 Function

Yuu Miyauchi, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie, Hideyuki Yamada and Yuji Ishii
Molecular Pharmacology October 1, 2015, 88 (4) 800-812; DOI: https://doi.org/10.1124/mol.115.098582

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Research ArticleArticle

UGT2B7 Suppresses CYP3A4 Function

Yuu Miyauchi, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie, Hideyuki Yamada and Yuji Ishii
Molecular Pharmacology October 1, 2015, 88 (4) 800-812; DOI: https://doi.org/10.1124/mol.115.098582
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