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Molecular Pharmacology

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Research ArticleArticle

Suppression of Cytochrome P450 3A4 Function by UDP-Glucuronosyltransferase 2B7 through a Protein-Protein Interaction: Cooperative Roles of the Cytosolic Carboxyl-Terminal Domain and the Luminal Anchoring Region

Yuu Miyauchi, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie, Hideyuki Yamada and Yuji Ishii
Molecular Pharmacology October 2015, 88 (4) 800-812; DOI: https://doi.org/10.1124/mol.115.098582
Yuu Miyauchi
Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (Y.M., H.Y., Y.I.); Tohoku Pharmaceutical University, Sendai, Japan (K.N.); Food Safety Commission, Cabinet Office, Government of Japan, Tokyo, Japan (Y.Y.); and Department of Clinical Pharmacology, Flinders Medical Center and Flinders University, Adelaide, Australia (P.I.M.)
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Kiyoshi Nagata
Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (Y.M., H.Y., Y.I.); Tohoku Pharmaceutical University, Sendai, Japan (K.N.); Food Safety Commission, Cabinet Office, Government of Japan, Tokyo, Japan (Y.Y.); and Department of Clinical Pharmacology, Flinders Medical Center and Flinders University, Adelaide, Australia (P.I.M.)
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Yasushi Yamazoe
Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (Y.M., H.Y., Y.I.); Tohoku Pharmaceutical University, Sendai, Japan (K.N.); Food Safety Commission, Cabinet Office, Government of Japan, Tokyo, Japan (Y.Y.); and Department of Clinical Pharmacology, Flinders Medical Center and Flinders University, Adelaide, Australia (P.I.M.)
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Peter I. Mackenzie
Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (Y.M., H.Y., Y.I.); Tohoku Pharmaceutical University, Sendai, Japan (K.N.); Food Safety Commission, Cabinet Office, Government of Japan, Tokyo, Japan (Y.Y.); and Department of Clinical Pharmacology, Flinders Medical Center and Flinders University, Adelaide, Australia (P.I.M.)
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Hideyuki Yamada
Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (Y.M., H.Y., Y.I.); Tohoku Pharmaceutical University, Sendai, Japan (K.N.); Food Safety Commission, Cabinet Office, Government of Japan, Tokyo, Japan (Y.Y.); and Department of Clinical Pharmacology, Flinders Medical Center and Flinders University, Adelaide, Australia (P.I.M.)
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Yuji Ishii
Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (Y.M., H.Y., Y.I.); Tohoku Pharmaceutical University, Sendai, Japan (K.N.); Food Safety Commission, Cabinet Office, Government of Japan, Tokyo, Japan (Y.Y.); and Department of Clinical Pharmacology, Flinders Medical Center and Flinders University, Adelaide, Australia (P.I.M.)
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Molecular Pharmacology: 88 (4)
Molecular Pharmacology
Vol. 88, Issue 4
1 Oct 2015
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Research ArticleArticle

UGT2B7 Suppresses CYP3A4 Function

Yuu Miyauchi, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie, Hideyuki Yamada and Yuji Ishii
Molecular Pharmacology October 1, 2015, 88 (4) 800-812; DOI: https://doi.org/10.1124/mol.115.098582

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Research ArticleArticle

UGT2B7 Suppresses CYP3A4 Function

Yuu Miyauchi, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie, Hideyuki Yamada and Yuji Ishii
Molecular Pharmacology October 1, 2015, 88 (4) 800-812; DOI: https://doi.org/10.1124/mol.115.098582
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