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Molecular Pharmacology

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Research ArticleArticle

Critical Cysteine Residues in Both the Calcium-Sensing Receptor and the Allosteric Activator AMG 416 Underlie the Mechanism of Action

Shawn T. Alexander, Thomas Hunter, Sarah Walter, Jin Dong, Derek Maclean, Amos Baruch, Raju Subramanian and James E. Tomlinson
Molecular Pharmacology November 2015, 88 (5) 853-865; DOI: https://doi.org/10.1124/mol.115.098392
Shawn T. Alexander
Amgen, Thousand Oaks, California
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Thomas Hunter
Amgen, Thousand Oaks, California
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Sarah Walter
Amgen, Thousand Oaks, California
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Jin Dong
Amgen, Thousand Oaks, California
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Derek Maclean
Amgen, Thousand Oaks, California
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Amos Baruch
Amgen, Thousand Oaks, California
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Raju Subramanian
Amgen, Thousand Oaks, California
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James E. Tomlinson
Amgen, Thousand Oaks, California
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Article Information

vol. 88 no. 5 853-865
DOI 
https://doi.org/10.1124/mol.115.098392
PubMed 
26290606

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received February 26, 2015
  • Accepted August 18, 2015
  • Published online September 30, 2015.

Article Versions

  • Earlier version (August 19, 2015 - 07:07).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Shawn T. Alexander,
  2. Thomas Hunter,
  3. Sarah Walter,
  4. Jin Dong,
  5. Derek Maclean,
  6. Amos Baruch,
  7. Raju Subramanian, and
  8. James E. Tomlinson
  1. Amgen, Thousand Oaks, California
  1. Address correspondence to:
    Shawn T. Alexander, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080. E-mail: shawna{at}amgen.com
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Molecular Pharmacology: 88 (5)
Molecular Pharmacology
Vol. 88, Issue 5
1 Nov 2015
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Research ArticleArticle

Mechanism of Action of AMG 416

Shawn T. Alexander, Thomas Hunter, Sarah Walter, Jin Dong, Derek Maclean, Amos Baruch, Raju Subramanian and James E. Tomlinson
Molecular Pharmacology November 1, 2015, 88 (5) 853-865; DOI: https://doi.org/10.1124/mol.115.098392

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Research ArticleArticle

Mechanism of Action of AMG 416

Shawn T. Alexander, Thomas Hunter, Sarah Walter, Jin Dong, Derek Maclean, Amos Baruch, Raju Subramanian and James E. Tomlinson
Molecular Pharmacology November 1, 2015, 88 (5) 853-865; DOI: https://doi.org/10.1124/mol.115.098392
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