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Molecular Pharmacology

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Table of Contents

December 01, 2015; Volume 88,Issue 6

Commentary

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    The Effective Application of Biased Signaling to New Drug Discovery
    Terry Kenakin
    Molecular Pharmacology December 2015, 88 (6) 1055-1061; DOI: https://doi.org/10.1124/mol.115.099770

Articles

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    Identification of an EGFRvIII-JNK2-HGF/c-Met–Signaling Axis Required for Intercellular Crosstalk and Glioblastoma Multiforme Cell Invasion
    Vanessa C. Saunders, Marie Lafitte, Isabel Adrados, Victor Quereda, Daniel Feurstein, YuanYuan Ling, Mohammad Fallahi, Laura H. Rosenberg and Derek R. Duckett
    Molecular Pharmacology December 2015, 88 (6) 962-969; DOI: https://doi.org/10.1124/mol.115.097774
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    Oxidative Stress and Response to Thymidylate Synthase-Targeted Antimetabolites
    Ufuk Ozer, Karen W. Barbour, Sarah A. Clinton and Franklin G. Berger
    Molecular Pharmacology December 2015, 88 (6) 970-981; DOI: https://doi.org/10.1124/mol.115.099614
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    Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding
    Adam J. Stein, Gretchen Bain, Pat Prodanovich, Angelina M. Santini, Janice Darlington, Nina M. P. Stelzer, Ranjinder S. Sidhu, Jeffrey Schaub, Lance Goulet, Dave Lonergan, Imelda Calderon, Jilly F. Evans and John H. Hutchinson
    Molecular Pharmacology December 2015, 88 (6) 982-992; DOI: https://doi.org/10.1124/mol.115.100404
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    Molecular Basis for Differential Sensitivity of α-Conotoxin RegIIA at Rat and Human Neuronal Nicotinic Acetylcholine Receptors
    Shiva N. Kompella, Hartmut Cuny, Andrew Hung and David J. Adams
    Molecular Pharmacology December 2015, 88 (6) 993-1001; DOI: https://doi.org/10.1124/mol.115.100503
  • Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target Na<sub>V</sub>1.7
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    Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7
    Julie K. Klint, Yanni K.-Y. Chin and Mehdi Mobli
    Molecular Pharmacology December 2015, 88 (6) 1002-1010; DOI: https://doi.org/10.1124/mol.115.100784
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    Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity
    Nestor O. Concha, Angela Smallwood, William Bonnette, Rachel Totoritis, Guofeng Zhang, Kelly Federowicz, Jingsong Yang, Hongwei Qi, Stephanie Chen, Nino Campobasso, Anthony E. Choudhry, Leanna E. Shuster, Karen A. Evans, Jeff Ralph, Sharon Sweitzer, Dirk A. Heerding, Carolyn A. Buser, Dai-Shi Su and M. Phillip DeYoung
    Molecular Pharmacology December 2015, 88 (6) 1011-1023; DOI: https://doi.org/10.1124/mol.115.100917
  • Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol–Bound <em>β</em><sub>1</sub>-Adrenergic Receptor
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    Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol–Bound β1-Adrenergic Receptor
    Tomomi Sato, Jillian Baker, Tony Warne, Giles A. Brown, Andrew G.W. Leslie, Miles Congreve and Christopher G. Tate
    Molecular Pharmacology December 2015, 88 (6) 1024-1034; DOI: https://doi.org/10.1124/mol.115.101030
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    Nicotine Dependence Reveals Distinct Responses from Neurons and Their Resident Nicotinic Receptors in Medial Habenula
    Pei-Yu Shih, J. Michael McIntosh and Ryan M. Drenan
    Molecular Pharmacology December 2015, 88 (6) 1035-1044; DOI: https://doi.org/10.1124/mol.115.101444
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    A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity
    Rui Xiong, Wenbo Zhou, David Siegel, Russell R. A. Kitson, Curt R. Freed, Christopher J. Moody and David Ross
    Molecular Pharmacology December 2015, 88 (6) 1045-1054; DOI: https://doi.org/10.1124/mol.115.101451
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    AMPK Inhibits the Stimulatory Effects of TGF-β on Smad2/3 Activity, Cell Migration, and Epithelial-to-Mesenchymal Transition
    Hui Lin, Nianshuang Li, Huan He, Ying Ying, Shashank Sunkara, Lingyu Luo, Nonghua Lv, Deqiang Huang and Zhijun Luo
    Molecular Pharmacology December 2015, 88 (6) 1062-1071; DOI: https://doi.org/10.1124/mol.115.099549
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    An Essential Role of cAMP Response Element Binding Protein in Ginsenoside Rg1-Mediated Inhibition of Na+/Glucose Cotransporter 1 Gene Expression
    Chun-Wen Wang, Shih-Chieh Su, Shu-Fen Huang, Yu-Chuan Huang, Fang-Na Chan, Yu-Han Kuo, Mei-Whey Hung, Hang-Chin Lin, Wen-Liang Chang and Tsu-Chung Chang
    Molecular Pharmacology December 2015, 88 (6) 1072-1083; DOI: https://doi.org/10.1124/mol.114.097352
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    Impaired Hepatic Uptake by Organic Anion-Transporting Polypeptides Is Associated with Hyperbilirubinemia and Hypercholanemia in Atp11c Mutant Mice
    Yusuke Matsuzaka, Hisamitsu Hayashi and Hiroyuki Kusuhara
    Molecular Pharmacology December 2015, 88 (6) 1085-1092; DOI: https://doi.org/10.1124/mol.115.100578

Erratum

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    Correction to “Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore”
    Molecular Pharmacology December 2015, 88 (6) 1084; DOI: https://doi.org/10.1124/mol.115.097550err
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Molecular Pharmacology: 88 (6)
Molecular Pharmacology
Vol. 88, Issue 6
1 Dec 2015
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