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Molecular Pharmacology

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Research ArticleArticle

Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination

Amelia M. Huehls, Catherine J. Huntoon, Poorval M. Joshi, Carly A. Baehr, Jill M. Wagner, Xiaoxiao Wang, Marietta Y. Lee and Larry M. Karnitz
Molecular Pharmacology January 2016, 89 (1) 53-62; DOI: https://doi.org/10.1124/mol.115.100164
Amelia M. Huehls
Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)
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Catherine J. Huntoon
Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)
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Poorval M. Joshi
Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)
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Carly A. Baehr
Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)
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Jill M. Wagner
Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)
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Xiaoxiao Wang
Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)
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Marietta Y. Lee
Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)
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Larry M. Karnitz
Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)
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Article Information

vol. 89 no. 1 53-62
DOI 
https://doi.org/10.1124/mol.115.100164
PubMed 
26494862

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received May 29, 2015
  • Accepted October 21, 2015
  • Published online November 24, 2015.

Article Versions

  • Earlier version (October 22, 2015 - 06:15).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Amelia M. Huehls,
  2. Catherine J. Huntoon,
  3. Poorval M. Joshi,
  4. Carly A. Baehr,
  5. Jill M. Wagner,
  6. Xiaoxiao Wang,
  7. Marietta Y. Lee, and
  8. Larry M. Karnitz
  1. Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)
  1. Address correspondence to:
    Larry M. Karnitz, Division of Oncology Research, Gonda 19-300, Mayo Clinic, 200 First Street SW, Rochester, MN 55905. E-mail: karnitz.larry{at}mayo.edu
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Molecular Pharmacology: 89 (1)
Molecular Pharmacology
Vol. 89, Issue 1
1 Jan 2016
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Research ArticleArticle

UNG Depletion Sensitizes to Floxuridine

Amelia M. Huehls, Catherine J. Huntoon, Poorval M. Joshi, Carly A. Baehr, Jill M. Wagner, Xiaoxiao Wang, Marietta Y. Lee and Larry M. Karnitz
Molecular Pharmacology January 1, 2016, 89 (1) 53-62; DOI: https://doi.org/10.1124/mol.115.100164

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Research ArticleArticle

UNG Depletion Sensitizes to Floxuridine

Amelia M. Huehls, Catherine J. Huntoon, Poorval M. Joshi, Carly A. Baehr, Jill M. Wagner, Xiaoxiao Wang, Marietta Y. Lee and Larry M. Karnitz
Molecular Pharmacology January 1, 2016, 89 (1) 53-62; DOI: https://doi.org/10.1124/mol.115.100164
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