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Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination
Amelia M. Huehls, Catherine J. Huntoon, Poorval M. Joshi, Carly A. Baehr, Jill M. Wagner, Xiaoxiao Wang, Marietta Y. Lee and Larry M. Karnitz
Molecular Pharmacology January 2016, 89 (1) 53-62; DOI: https://doi.org/10.1124/mol.115.100164
Amelia M. Huehls
Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)
Catherine J. Huntoon
Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)
Poorval M. Joshi
Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)
Carly A. Baehr
Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)
Jill M. Wagner
Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)
Xiaoxiao Wang
Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)
Marietta Y. Lee
Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)
Larry M. Karnitz
Department of Molecular Pharmacology and Experimental Therapeutics (A.M.H., C.J.H., P.M.J., C.A.B., J.M.W., L.M.K.) and Division of Oncology Research (C.J.H., J.M.W., L.M.K), Department of Radiation Oncology (L.M.K.), Mayo Clinic, Rochester, Minnesota; and Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York (X.W., M.Y.L.)

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Research ArticleArticle
UNG Depletion Sensitizes to Floxuridine
Amelia M. Huehls, Catherine J. Huntoon, Poorval M. Joshi, Carly A. Baehr, Jill M. Wagner, Xiaoxiao Wang, Marietta Y. Lee and Larry M. Karnitz
Molecular Pharmacology January 1, 2016, 89 (1) 53-62; DOI: https://doi.org/10.1124/mol.115.100164
Research ArticleArticle
UNG Depletion Sensitizes to Floxuridine
Amelia M. Huehls, Catherine J. Huntoon, Poorval M. Joshi, Carly A. Baehr, Jill M. Wagner, Xiaoxiao Wang, Marietta Y. Lee and Larry M. Karnitz
Molecular Pharmacology January 1, 2016, 89 (1) 53-62; DOI: https://doi.org/10.1124/mol.115.100164
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