Research ArticleArticle
Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design
Cristina C. Rohena, Nakul S. Telang, Chenxiao Da, April L. Risinger, James A. Sikorski, Glen E. Kellogg, John T. Gupton and Susan L. Mooberry
Molecular Pharmacology February 2016, 89 (2) 287-296; DOI: https://doi.org/10.1124/mol.115.101592
Cristina C. Rohena
Department of Pharmacology and Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas (C.C.R., A.L.R., S.L.M.); Department of Chemistry University of Richmond, Richmond Virginia (N.T., J.T.G.); Department of Medicinal Chemistry and Institute of Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia (C.D., G.E.K.); and Medicinal Chemistry & Drug Discovery, Chesterfield, Missouri (J.A.S.).
Nakul S. Telang
Department of Pharmacology and Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas (C.C.R., A.L.R., S.L.M.); Department of Chemistry University of Richmond, Richmond Virginia (N.T., J.T.G.); Department of Medicinal Chemistry and Institute of Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia (C.D., G.E.K.); and Medicinal Chemistry & Drug Discovery, Chesterfield, Missouri (J.A.S.).
Chenxiao Da
Department of Pharmacology and Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas (C.C.R., A.L.R., S.L.M.); Department of Chemistry University of Richmond, Richmond Virginia (N.T., J.T.G.); Department of Medicinal Chemistry and Institute of Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia (C.D., G.E.K.); and Medicinal Chemistry & Drug Discovery, Chesterfield, Missouri (J.A.S.).
April L. Risinger
Department of Pharmacology and Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas (C.C.R., A.L.R., S.L.M.); Department of Chemistry University of Richmond, Richmond Virginia (N.T., J.T.G.); Department of Medicinal Chemistry and Institute of Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia (C.D., G.E.K.); and Medicinal Chemistry & Drug Discovery, Chesterfield, Missouri (J.A.S.).
James A. Sikorski
Department of Pharmacology and Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas (C.C.R., A.L.R., S.L.M.); Department of Chemistry University of Richmond, Richmond Virginia (N.T., J.T.G.); Department of Medicinal Chemistry and Institute of Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia (C.D., G.E.K.); and Medicinal Chemistry & Drug Discovery, Chesterfield, Missouri (J.A.S.).
Glen E. Kellogg
Department of Pharmacology and Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas (C.C.R., A.L.R., S.L.M.); Department of Chemistry University of Richmond, Richmond Virginia (N.T., J.T.G.); Department of Medicinal Chemistry and Institute of Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia (C.D., G.E.K.); and Medicinal Chemistry & Drug Discovery, Chesterfield, Missouri (J.A.S.).
John T. Gupton
Department of Pharmacology and Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas (C.C.R., A.L.R., S.L.M.); Department of Chemistry University of Richmond, Richmond Virginia (N.T., J.T.G.); Department of Medicinal Chemistry and Institute of Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia (C.D., G.E.K.); and Medicinal Chemistry & Drug Discovery, Chesterfield, Missouri (J.A.S.).
Susan L. Mooberry
Department of Pharmacology and Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas (C.C.R., A.L.R., S.L.M.); Department of Chemistry University of Richmond, Richmond Virginia (N.T., J.T.G.); Department of Medicinal Chemistry and Institute of Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia (C.D., G.E.K.); and Medicinal Chemistry & Drug Discovery, Chesterfield, Missouri (J.A.S.).
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Research ArticleArticle
Modeling Identifies an Improved Colchicine-Site Agent
Cristina C. Rohena, Nakul S. Telang, Chenxiao Da, April L. Risinger, James A. Sikorski, Glen E. Kellogg, John T. Gupton and Susan L. Mooberry
Molecular Pharmacology February 1, 2016, 89 (2) 287-296; DOI: https://doi.org/10.1124/mol.115.101592
Research ArticleArticle
Modeling Identifies an Improved Colchicine-Site Agent
Cristina C. Rohena, Nakul S. Telang, Chenxiao Da, April L. Risinger, James A. Sikorski, Glen E. Kellogg, John T. Gupton and Susan L. Mooberry
Molecular Pharmacology February 1, 2016, 89 (2) 287-296; DOI: https://doi.org/10.1124/mol.115.101592
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