Table of Contents

Articles

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  Molecular Basis of Ligand Dissociation from the Adenosine A_2A Receptor

  Dong Guo, Albert C. Pan, Ron O. Dror, Tamara Mocking, Rongfang Liu, Laura H. Heitman, David E. Shaw and Adriaan P. IJzerman

  Molecular Pharmacology May 2016, 89 (5) 485-491; DOI: https://doi.org/10.1124/mol.115.102657
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  Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model

  Shannon Dallas, Laurent Salphati, David Gomez-Zepeda, Thomas Wanek, Liangfu Chen, Xiaoyan Chu, Jeevan Kunta, Mario Mezler, Marie-Claude Menet, Stephanie Chasseigneaux, Xavier Declèves, Oliver Langer, Esaie Pierre, Karen DiLoreto, Carolin Hoft, Loic Laplanche, Jodie Pang, Tony Pereira, Clara Andonian, Damir Simic, Anja Rode, Jocelyn Yabut, Xiaolin Zhang and Nico Scheer

  Molecular Pharmacology May 2016, 89 (5) 492-504; DOI: https://doi.org/10.1124/mol.115.102079
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  Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein–Coupled Receptor 120

  Rudi Prihandoko, Elisa Alvarez-Curto, Brian D. Hudson, Adrian J. Butcher, Trond Ulven, Ashley M. Miller, Andrew B. Tobin and Graeme Milligan

  Molecular Pharmacology May 2016, 89 (5) 505-520; DOI: https://doi.org/10.1124/mol.115.101949
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  Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling

  Xiongzhi Wangpu, Jiaoyang Lu, Ruxing Xi, Fei Yue, Sumit Sahni, Kyung Chan Park, Sharleen Menezes, Michael L.H. Huang, Minhua Zheng, Zaklina Kovacevic and Des R. Richardson

  Molecular Pharmacology May 2016, 89 (5) 521-540; DOI: https://doi.org/10.1124/mol.115.103044
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  Open Access

  A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists

  David Stroebel, Derek L. Buhl, John D. Knafels, Pranab K. Chanda, Michael Green, Simone Sciabola, Laetitia Mony, Pierre Paoletti and Jayvardhan Pandit

  Molecular Pharmacology May 2016, 89 (5) 541-551; DOI: https://doi.org/10.1124/mol.115.103036
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  Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid β-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss

  Ronald K. Freund, Emily S. Gibson, Huntington Potter and Mark L. Dell’Acqua

  Molecular Pharmacology May 2016, 89 (5) 552-559; DOI: https://doi.org/10.1124/mol.115.103085
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  RETRACTION: All-Trans-Retinoic Acid Enhances Mitochondrial Function in Models of Human Liver

  Sasmita Tripathy, John D Chapman, Chang Y Han, Cathryn A Hogarth, Samuel L.M. Arnold, Jennifer Onken, Travis Kent, David R Goodlett and Nina Isoherranen

  Molecular Pharmacology May 2016, 89 (5) 560-574; DOI: https://doi.org/10.1124/mol.116.103697
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  Photolabeling a Nicotinic Acetylcholine Receptor (nAChR) with an (α4)₃(β2)₂ nAChR-Selective Positive Allosteric Modulator

  Ayman K. Hamouda, Farah Deba, Ze-Jun Wang and Jonathan B. Cohen

  Molecular Pharmacology May 2016, 89 (5) 575-584; DOI: https://doi.org/10.1124/mol.116.103341
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  Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy

  David A. Sykes, Michelle E. Bradley, Darren M. Riddy, Elizabeth Willard, John Reilly, Asadh Miah, Carsten Bauer, Simon J. Watson, David A. Sandham, Gerald Dubois and Steven J. Charlton

  Molecular Pharmacology May 2016, 89 (5) 593-605; DOI: https://doi.org/10.1124/mol.115.101832