Research ArticleArticle
Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling
Xiongzhi Wangpu, Jiaoyang Lu, Ruxing Xi, Fei Yue, Sumit Sahni, Kyung Chan Park, Sharleen Menezes, Michael L.H. Huang, Minhua Zheng, Zaklina Kovacevic and Des R. Richardson
Molecular Pharmacology May 2016, 89 (5) 521-540; DOI: https://doi.org/10.1124/mol.115.103044
Xiongzhi Wangpu
Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C.P., S.M., M.L.H.H., Z.K., D.R.R.); and Department of Radiotherapy, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, China (R.X.)
Jiaoyang Lu
Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C.P., S.M., M.L.H.H., Z.K., D.R.R.); and Department of Radiotherapy, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, China (R.X.)
Ruxing Xi
Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C.P., S.M., M.L.H.H., Z.K., D.R.R.); and Department of Radiotherapy, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, China (R.X.)
Fei Yue
Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C.P., S.M., M.L.H.H., Z.K., D.R.R.); and Department of Radiotherapy, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, China (R.X.)
Sumit Sahni
Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C.P., S.M., M.L.H.H., Z.K., D.R.R.); and Department of Radiotherapy, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, China (R.X.)
Kyung Chan Park
Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C.P., S.M., M.L.H.H., Z.K., D.R.R.); and Department of Radiotherapy, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, China (R.X.)
Sharleen Menezes
Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C.P., S.M., M.L.H.H., Z.K., D.R.R.); and Department of Radiotherapy, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, China (R.X.)
Michael L.H. Huang
Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C.P., S.M., M.L.H.H., Z.K., D.R.R.); and Department of Radiotherapy, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, China (R.X.)
Minhua Zheng
Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C.P., S.M., M.L.H.H., Z.K., D.R.R.); and Department of Radiotherapy, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, China (R.X.)
Zaklina Kovacevic
Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C.P., S.M., M.L.H.H., Z.K., D.R.R.); and Department of Radiotherapy, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, China (R.X.)
Des R. Richardson
Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C.P., S.M., M.L.H.H., Z.K., D.R.R.); and Department of Radiotherapy, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, China (R.X.)
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NDRG1 Inhibits FAK/Paxillin Pathway in Cancer Cells
Xiongzhi Wangpu, Jiaoyang Lu, Ruxing Xi, Fei Yue, Sumit Sahni, Kyung Chan Park, Sharleen Menezes, Michael L.H. Huang, Minhua Zheng, Zaklina Kovacevic and Des R. Richardson
Molecular Pharmacology May 1, 2016, 89 (5) 521-540; DOI: https://doi.org/10.1124/mol.115.103044
Research ArticleArticle
NDRG1 Inhibits FAK/Paxillin Pathway in Cancer Cells
Xiongzhi Wangpu, Jiaoyang Lu, Ruxing Xi, Fei Yue, Sumit Sahni, Kyung Chan Park, Sharleen Menezes, Michael L.H. Huang, Minhua Zheng, Zaklina Kovacevic and Des R. Richardson
Molecular Pharmacology May 1, 2016, 89 (5) 521-540; DOI: https://doi.org/10.1124/mol.115.103044
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