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Molecular Pharmacology

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Research ArticleArticle

Stimulation by Acetylcholine of Sulfated Mucopolysaccharide Release from the Perfused Cat Adrenal Gland

R. K. MARGOLIS, S. D. JAANUS and R. U. MAUGOLIS
Molecular Pharmacology July 1973, 9 (4) 590-594;
R. K. MARGOLIS
Department of Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203; Department of Biological Sciences, State University of New York, College of Optometry, New York, New York 10010; and Department of Pharmacology, New York University School of Medicine, New York, New York 10016
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S. D. JAANUS
Department of Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203; Department of Biological Sciences, State University of New York, College of Optometry, New York, New York 10010; and Department of Pharmacology, New York University School of Medicine, New York, New York 10016
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R. U. MAUGOLIS
Department of Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203; Department of Biological Sciences, State University of New York, College of Optometry, New York, New York 10010; and Department of Pharmacology, New York University School of Medicine, New York, New York 10016
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Abstract

Sulfated complex carbohydrates in the adrenal medulla were labeled with 35SO4- after the administration of insulin to deplete catecholamine stores. Twenty-four hours later the left adrenal gland was perfused in situ with Locke's solution. Addition of acetylcholine to the perfusion solution resulted in a 12-20-fold increase in the release of sulfate-labeled nondialyzable material, together with the usual large increase in catecholamine secretion. Digestion of the sulfate-labeled macromolecular material with bacterial chondroitinases demonstrated that 65-80% of the radioactivity was in the form of chondroitin 4- and 6-sulfate. The remaining radioactivity was present in an N-sulfated mucopolysaccharide which was tentatively identified as heparan sulfate. The results of these experiments are consistent with our previous finding of sulfated mucopolysaccharides, consisting mostly of chondroitin 4- and 6-sulfate, in purified chromaffin granules from bovine adrenal medulla, and are discussed in terms of the possible role of anionic complex carbohydrates in the storage and release of biogenic amines.

  • Copyright ©, 1973, by Academic Press, Inc.

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Molecular Pharmacology
Vol. 9, Issue 4
1 Jul 1973
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Research ArticleArticle

Stimulation by Acetylcholine of Sulfated Mucopolysaccharide Release from the Perfused Cat Adrenal Gland

R. K. MARGOLIS, S. D. JAANUS and R. U. MAUGOLIS
Molecular Pharmacology July 1, 1973, 9 (4) 590-594;

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Research ArticleArticle

Stimulation by Acetylcholine of Sulfated Mucopolysaccharide Release from the Perfused Cat Adrenal Gland

R. K. MARGOLIS, S. D. JAANUS and R. U. MAUGOLIS
Molecular Pharmacology July 1, 1973, 9 (4) 590-594;
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