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Research ArticleMinireview—A Latin American Perspective on Ion Channels

Structure-Driven Pharmacology of Transient Receptor Potential Channel Vanilloid 1

Ignacio Díaz-Franulic, Javier Caceres-Molina, Romina V. Sepulveda, Fernando Gonzalez-Nilo and Ramon Latorre
Molecular Pharmacology September 2016, 90 (3) 300-308; DOI: https://doi.org/10.1124/mol.116.104430
Ignacio Díaz-Franulic
Centro Interdisciplinario de Neurociencias de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile (I.D.-F., R.L., F.G.-N.); Centro de Bioinformática y Biología Integrativa, Universidad Andrés Bello, Santiago, Chile (I.D.-F., J.C.-M., R.V.S., F.G.-N.); and Fraunhofer Chile Research, Santiago, Chile (I.D.-F.)
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Javier Caceres-Molina
Centro Interdisciplinario de Neurociencias de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile (I.D.-F., R.L., F.G.-N.); Centro de Bioinformática y Biología Integrativa, Universidad Andrés Bello, Santiago, Chile (I.D.-F., J.C.-M., R.V.S., F.G.-N.); and Fraunhofer Chile Research, Santiago, Chile (I.D.-F.)
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Romina V. Sepulveda
Centro Interdisciplinario de Neurociencias de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile (I.D.-F., R.L., F.G.-N.); Centro de Bioinformática y Biología Integrativa, Universidad Andrés Bello, Santiago, Chile (I.D.-F., J.C.-M., R.V.S., F.G.-N.); and Fraunhofer Chile Research, Santiago, Chile (I.D.-F.)
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Fernando Gonzalez-Nilo
Centro Interdisciplinario de Neurociencias de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile (I.D.-F., R.L., F.G.-N.); Centro de Bioinformática y Biología Integrativa, Universidad Andrés Bello, Santiago, Chile (I.D.-F., J.C.-M., R.V.S., F.G.-N.); and Fraunhofer Chile Research, Santiago, Chile (I.D.-F.)
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Ramon Latorre
Centro Interdisciplinario de Neurociencias de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile (I.D.-F., R.L., F.G.-N.); Centro de Bioinformática y Biología Integrativa, Universidad Andrés Bello, Santiago, Chile (I.D.-F., J.C.-M., R.V.S., F.G.-N.); and Fraunhofer Chile Research, Santiago, Chile (I.D.-F.)
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Article Information

vol. 90 no. 3 300-308
DOI 
https://doi.org/10.1124/mol.116.104430
PubMed 
27335334

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received March 26, 2016
  • Accepted June 16, 2016
  • Published online August 17, 2016.

Article Versions

  • Earlier version (June 22, 2016 - 07:27).
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Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ignacio Díaz-Franulic,
  2. Javier Caceres-Molina,
  3. Romina V. Sepulveda,
  4. Fernando Gonzalez-Nilo, and
  5. Ramon Latorre
  1. Centro Interdisciplinario de Neurociencias de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile (I.D.-F., R.L., F.G.-N.); Centro de Bioinformática y Biología Integrativa, Universidad Andrés Bello, Santiago, Chile (I.D.-F., J.C.-M., R.V.S., F.G.-N.); and Fraunhofer Chile Research, Santiago, Chile (I.D.-F.)
  1. Address correspondence to:
    Ignacio Díaz-Franulic, Centro de Bioinformática y Biología Integrativa, Universidad Andrés Bello, Santiago 8370146, Chile. E-mail: ignacio.diaz{at}cinv.cl or Ramon Latorre, Centro Interdisciplinario de Neurociencia de Valparaíso, Pasaje Harrington 287, Playa Ancha, Valparaíso 2366103, Chile. E-mail: ramon.latorre{at}uv.cl
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Molecular Pharmacology: 90 (3)
Molecular Pharmacology
Vol. 90, Issue 3
1 Sep 2016
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Research ArticleMinireview—A Latin American Perspective on Ion Channels

Ligand Binding on TRPV1 Channels

Ignacio Díaz-Franulic, Javier Caceres-Molina, Romina V. Sepulveda, Fernando Gonzalez-Nilo and Ramon Latorre
Molecular Pharmacology September 1, 2016, 90 (3) 300-308; DOI: https://doi.org/10.1124/mol.116.104430

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Research ArticleMinireview—A Latin American Perspective on Ion Channels

Ligand Binding on TRPV1 Channels

Ignacio Díaz-Franulic, Javier Caceres-Molina, Romina V. Sepulveda, Fernando Gonzalez-Nilo and Ramon Latorre
Molecular Pharmacology September 1, 2016, 90 (3) 300-308; DOI: https://doi.org/10.1124/mol.116.104430
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  • Article
    • Visual Overview
    • Abstract
    • Introduction
    • Ligand Binding at the Vanilloid Binding Pocket
    • Peptide Toxins as TRPV1 Channel Modulators
    • Modulation of TRPV1 Channel Gating by Lipids
    • Concluding Remarks
    • Acknowledgments
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  • Gating, Regulation, and Structure in K2P K+ Channels
  • Conversion of an Inward into an Outward Rectifier Channel
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