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Research ArticleMinireview—A Latin American Perspective on Ion Channels

Gating, Regulation, and Structure in K2P K+ Channels: In Varietate Concordia?

María Isabel Niemeyer, L. Pablo Cid, Wendy González and Francisco V. Sepúlveda
Molecular Pharmacology September 2016, 90 (3) 309-317; DOI: https://doi.org/10.1124/mol.116.103895
María Isabel Niemeyer
Centro de Estudios Científicos (CECs), Valdivia, Chile (M.I.N., L.P.C., F.V.S.), Centro de Bioinformática y Simulación Molecular (CBSM), Universidad de Talca, Talca, Chile (W.G.)
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L. Pablo Cid
Centro de Estudios Científicos (CECs), Valdivia, Chile (M.I.N., L.P.C., F.V.S.), Centro de Bioinformática y Simulación Molecular (CBSM), Universidad de Talca, Talca, Chile (W.G.)
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Wendy González
Centro de Estudios Científicos (CECs), Valdivia, Chile (M.I.N., L.P.C., F.V.S.), Centro de Bioinformática y Simulación Molecular (CBSM), Universidad de Talca, Talca, Chile (W.G.)
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Francisco V. Sepúlveda
Centro de Estudios Científicos (CECs), Valdivia, Chile (M.I.N., L.P.C., F.V.S.), Centro de Bioinformática y Simulación Molecular (CBSM), Universidad de Talca, Talca, Chile (W.G.)
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Article Information

vol. 90 no. 3 309-317
DOI 
https://doi.org/10.1124/mol.116.103895
PubMed 
27268784

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received February 18, 2016
  • Accepted May 31, 2016
  • Published online August 17, 2016.

Article Versions

  • Earlier version (June 6, 2016 - 10:56).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. María Isabel Niemeyer,
  2. L. Pablo Cid,
  3. Wendy González, and
  4. Francisco V. Sepúlveda
  1. Centro de Estudios Científicos (CECs), Valdivia, Chile (M.I.N., L.P.C., F.V.S.), Centro de Bioinformática y Simulación Molecular (CBSM), Universidad de Talca, Talca, Chile (W.G.)
  1. Address correspondence to:
    Francisco V. Sepúlveda or María Isabel Nimeyer, Centro de Estudios Científicos (CECs), Avenida Arturo Prat 514, 5110466 Valdivia, Chile. E-mails: fsepulveda{at}cecs.cl; miniemeyer{at}cecs.cl
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Molecular Pharmacology: 90 (3)
Molecular Pharmacology
Vol. 90, Issue 3
1 Sep 2016
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Research ArticleMinireview—A Latin American Perspective on Ion Channels

Gating, Regulation, and Structure in K2P K+ Channels

María Isabel Niemeyer, L. Pablo Cid, Wendy González and Francisco V. Sepúlveda
Molecular Pharmacology September 1, 2016, 90 (3) 309-317; DOI: https://doi.org/10.1124/mol.116.103895

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Research ArticleMinireview—A Latin American Perspective on Ion Channels

Gating, Regulation, and Structure in K2P K+ Channels

María Isabel Niemeyer, L. Pablo Cid, Wendy González and Francisco V. Sepúlveda
Molecular Pharmacology September 1, 2016, 90 (3) 309-317; DOI: https://doi.org/10.1124/mol.116.103895
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Jump to section

  • Article
    • Visual Overview
    • Abstract
    • Introduction
    • Gating Processes of K+ Channels
    • Molecular Structure of K2P Channels
    • Gating at the Selectivity Filter of K2P Channels
    • Is There the Equivalent of an Activation Gate Operative in K2P Channels?
    • An All-Encompassing Role for the Selectivity Filter in the Gating of K2P Channels
    • A Novel Hypothesis to Explain TRAAK Mechanosensitivity
    • TASK-2 and the K2P Channel Gating Hypotheses
    • Concluding Remarks
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

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