Research ArticleMinireview—A Latin American Perspective on Ion Channels
Pharmacological Conversion of a Cardiac Inward Rectifier into an Outward Rectifier Potassium Channel
Eloy G. Moreno-Galindo, Jose A. Sanchez-Chapula, Martin Tristani-Firouzi and Ricardo A. Navarro-Polanco
Molecular Pharmacology September 2016, 90 (3) 334-340; DOI: https://doi.org/10.1124/mol.116.104950
Eloy G. Moreno-Galindo
Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Colima, México (E.G.M.-G., J.A.S.-C., R.A.N.-P.); Nora Eccles Harrison Cardiovascular Research and Training Institute, and Division of Pediatric Cardiology, University of Utah, Salt Lake City, Utah (M.T.-F.)
Jose A. Sanchez-Chapula
Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Colima, México (E.G.M.-G., J.A.S.-C., R.A.N.-P.); Nora Eccles Harrison Cardiovascular Research and Training Institute, and Division of Pediatric Cardiology, University of Utah, Salt Lake City, Utah (M.T.-F.)
Martin Tristani-Firouzi
Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Colima, México (E.G.M.-G., J.A.S.-C., R.A.N.-P.); Nora Eccles Harrison Cardiovascular Research and Training Institute, and Division of Pediatric Cardiology, University of Utah, Salt Lake City, Utah (M.T.-F.)
Ricardo A. Navarro-Polanco
Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Colima, México (E.G.M.-G., J.A.S.-C., R.A.N.-P.); Nora Eccles Harrison Cardiovascular Research and Training Institute, and Division of Pediatric Cardiology, University of Utah, Salt Lake City, Utah (M.T.-F.)
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Research ArticleMinireview—A Latin American Perspective on Ion Channels
Conversion of an Inward into an Outward Rectifier Channel
Eloy G. Moreno-Galindo, Jose A. Sanchez-Chapula, Martin Tristani-Firouzi and Ricardo A. Navarro-Polanco
Molecular Pharmacology September 1, 2016, 90 (3) 334-340; DOI: https://doi.org/10.1124/mol.116.104950
Research ArticleMinireview—A Latin American Perspective on Ion Channels
Conversion of an Inward into an Outward Rectifier Channel
Eloy G. Moreno-Galindo, Jose A. Sanchez-Chapula, Martin Tristani-Firouzi and Ricardo A. Navarro-Polanco
Molecular Pharmacology September 1, 2016, 90 (3) 334-340; DOI: https://doi.org/10.1124/mol.116.104950
Jump to section
- Article
- Visual Overview
- Abstract
- Introduction
- The Molecular Basis for Inward Rectification of Kir Channels
- The Muscarinic G-Protein–Coupled Inward Rectifier KACh Channel
- An Outward Rectifier K+ Current Activated by Muscarinic Ligands
- Muscarinic Receptors Possess Intrinsic Voltage Sensitivity
- The Mechanism for Pharmacological Conversion of an Inward Rectifier into an Apparent Delayed Rectifier K+ Channel
- The Effect of Voltage on the Affinity and Efficacy of the M2R-Agonist Interaction
- Physiologic Implications of M2R Voltage Sensitivity for Parasympathetic Regulation of the Heart
- Conclusions
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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